Chicago White Sox vs Minnesota Twins Prediction, 9/4/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Minnesota Twins

Date: Thursday, September 4, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Chicago (+150) Minnesota (-182)

Target Field is the location where the Minnesota Twins (62-76) will go up against the Chicago White Sox (51-88) on Thursday. The moneyline on this game has Chicago at +150 and Minnesota is at -182. The over/under comes in at 9. The pitchers expected to start will be Shane Smith and Taj Bradley.

The White Sox have hit 211 doubles as a unit and have smacked 142 balls out of the park. Chicago has a slugging rate of .376 and have been called out on strikes 1,155 times, while drawing a walk on 436 occasions. As a squad, the Chicago White Sox are recording 4.0 runs per game, which is 26th in MLB. They have accrued 535 runs batted in as well as 1,085 base knocks over the course of the season, and their team batting average is at .234. They have tallied 554 runs scored and have an on-base percentage of .304.

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They have accrued a K/BB ratio of 2.08 and the pitching staff has a team WHIP of 1.37. White Sox pitchers have given up 155 home runs in addition to 636 runs in total (21st in baseball). Chicago has conceded 1,146 hits (8.5 per 9 innings) as well as 570 earned runs. The White Sox are sitting with a team ERA of 4.22 on the season (19th in the league), and their staff has rung up 1,072 hitters. Their pitching staff has walked 515 players from the other team and their FIP comes in at 4.47 as a squad over the course of the season.

White Sox bullpen pitchers have stepped onto the hill with runners on 136 times and also have had 125 appearances in high leverage situations. The relief pitchers have accumulated 56 holds over the course of the season (28th in baseball). The White Sox relief pitchers have earned a save percentage of 47.5% and have come into the game in 96 save situations. They have accumulated 19 saves this year and have not converted 21 of their 40 chances to save the game. The bullpen pitchers have inherited 199 runners so far this year with 32.7% of them crossed home plate. The White Sox have sent 445 relief pitchers to the hill for the year.

The White Sox have turned 69.7% of balls hit into play into outs out of 10,947 innings, which has them ranked 18th in MLB. The Chicago Cubs are sitting with 3,649 putouts so far this season, as well as 1,112 assists and 90 errors. Their fielding rate is at .981 which has them ranked 28th in baseball, and they have turned 112 double plays.

Smith has taken the ball for 120 frames and has tallied 112 strikeouts so far in his MLB career. Smith (4-7 career record) holds a FIP of 3.76 and he has faced 510 opposing hitters in the majors. His earned run average is 3.82 (51 ER's allowed) and he has a career WHIP of 1.207. He has given up 95 hits (7.1 hits per 9 innings) and has 50 walks.

The Twins hold a slugging percentage of .397 and they have an average of 4.21 runs per outing (23rd in MLB). They have put up 211 two-baggers, while getting a free base 423 times as well as racking up 581 runs. Minnesota has hit 163 HRs on the year as well as 553 runs batted in. They have struck out on 1,142 occasions (16th in MLB) and have recorded 1,098 hits. The Minnesota Twins hold a team OBP of .311 and a team batting average of .238 over the course of the season.

The Twins have a team WHIP of 1.322 in addition to having a FIP of 4.13 as a team this year. They currently have a strikeout to walk ratio of 8.60 (1,157 strikeouts against 389 walks). They are currently ranked 24th in MLB as a pitching staff in total hits given up with 1,217. They have allowed 168 long balls and they give up 4.84 runs per 9 innings (23rd in baseball). The Minnesota pitching staff have relinquished 654 runs on the season and come in with a team ERA of 4.51 (609 earned runs given up).

Minnesota has had relievers step onto the mound in 47 save opportunities and they have tallied 26 saves. They are currently ranked 26th in MLB holding a save percentage of 55.3%, and they have sent 469 relievers to the hill this season. Their relievers have stepped onto the mound 157 times in high leverage situations and also on 102 occasions with runners on. Minnesota relief pitchers have an inherited score percentage of 37.0% out of their 146 inherited base runners. Sitting with 131 save situations, the Twins have earned 82 holds in addition to 21 blown saves.

Out of their 10,935 innings played, the Twins hold a defensive efficiency of 68.3% (27th in the majors). The Minnesota Twins have gotten 85 double plays and own a fielding percentage of .986 (17th in pro baseball). The Twins have recorded 1,031 assists, 68 errors and have earned 3,645 putouts this season.

So far in his MLB career, Bradley has allowed 337 hits while earning 385 K's in 363 innings pitched. He has given up a total of 193 earned runs while earning a WHIP of 1.296 and a FIP of 4.7. His strikeout to walk ratio is 2.87 and he has faced 1,552 opposing batters during his career. Bradley (19-26 win-loss mark in his career) has a 4.78 earned run average while giving up 8.3 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Minnesota (-182)

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