Chicago White Sox vs New York Yankees Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs New York Yankees

Date: Tuesday, September 23, 2025

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Chicago (+106) New York (-128)

The New York Yankees (88-68) will play the Chicago White Sox (58-98) at Yankee Stadium on Tuesday. The moneyline on this game has the White Sox at +106 and the Yankees are priced at -128. The betting total is set at 8. The starting pitchers are Shane Smith and Luis Gil.

As a unit, the Chicago White Sox are scoring 4.0 runs per contest, which ranks them 26th in MLB. They have a total of 616 runs while holding a team on-base percentage of .302. The White Sox have accounted for 233 two-baggers as a team and have smacked 156 balls out of the park. They have accounted for 595 RBI's and 1,196 hits on the campaign, and their batting average sits at .233. Chicago owns a slugging percentage of .373 and have been rung up 1,302 times, while taking a walk on 477 occasions.

Get all of our MLB Parlay Picks

They have earned a strikeout to walk ratio of 2.12 and the pitching staff holds a WHIP of 1.36. White Sox pitchers have surrendered 176 long balls and also 708 runs (21st in baseball). Chicago has given up 1,274 base hits (8.5 per 9 innings) and 639 earned runs. The White Sox have compiled a team ERA of 4.24 on the season (20th in the league), and their staff has struck out 1,210 hitters. They have walked 570 opposing players and their FIP comes in at 4.47 as a unit on the season.

The White Sox have sent 505 relief pitchers to the mound so far this season. The relief pitchers have inherited 226 runners on the year and 31.9% of those players ended up scoring. They have accumulated 24 saves for the season and have not converted 21 of 45 save opportunities. The White Sox relief pitchers have a save percentage of 53.3% and have come into the game in 113 save situations. The relievers have a total of 66 holds on the season (27th in baseball). White Sox bullpen pitchers have entered the game with runners on 156 times in addition to having 144 appearances in high leverage situations.

The Chicago Cubs have a total of 4,069 putouts so far this season, as well as 1,225 assists and 96 errors. Their fielding percentage is at .982 which ranks 28th in the majors, and have a total of 125 double plays. The White Sox have turned 69.8% of balls in play into outs out of 12,207 innings, which has them sitting 19th in baseball.

Smith has taken the ball for 135 innings and has tallied 129 K's in his MLB career. Smith (6-8 career mark) holds a FIP of 4.00 and he has gone up against 574 opposing hitters in the majors. His earned run average is 4.06 (61 ER's allowed) and his WHIP is 1.221. He has surrendered 111 base knocks (7.4 hits per nine innings) and has 54 free passes.

The New York Yankees have accumulated a team OBP of .330 and a batting average of .250 so far this season. They have been rung up on 1,391 instances (3rd in the league) and are sitting with 1,310 base hits. New York has recorded 261 HRs so far this season and 781 RBIs. The Yankees hold a slugging % of .454 and they are earning 5.22 runs per game (1st in the league). They have 247 doubles, while getting a free base 603 times and recording 809 runs.

The New York pitching staff have allowed 671 runs for the season while having a team ERA of 4.00 (611 earned runs conceded). They have allowed 167 homers and they surrender 4.39 runs per 9 innings (17th in MLB). The Yankees have a WHIP of 1.263 in addition to having a FIP of 4.01 as a staff for the year. They have earned a K/BB ratio of 9.00 (1,375 strikeouts vs 534 walks). They rank 6th in the league as a pitching staff in total hits surrendered with 1,203.

With 159 save situations, the Yankees have accrued 95 holds and 21 blown saves. New York has called on bullpen pitchers to take the mound in 62 save opportunities and they have tallied 41 saves. Their relief pitchers have come in 156 times in high leverage situations in addition to 162 occasions with runners on base. New York relief pitchers have an inherited score percentage of 28.2% out of their 248 inherited runners. They rank 7th in the league holding a save rate of 66.1%, and they have dispatched 509 relievers onto the diamond this season.

The New York Yankees have turned 104 double plays and have a fielding rate of .984 (24th in MLB). The Yankees have recorded 1,341 assists, 90 errors and have earned 4,127 putouts so far this year. In 12,381 innings on the diamond, the Yankees have a defensive efficiency of 70.4% (10th in baseball).

During his MLB career, Gil has given up 169 hits while he has tallied 250 punch outs in 231 innings pitched. Gil (20-9 win-loss record in his career) has a 3.51 ERA while conceding 6.6 hits per nine innings. He has allowed 90 earned runs while holding a WHIP of 1.281 and a FIP of 3.5. His strikeout to walk ratio is 1.97 and he has gone up against 986 hitters so far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+106)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here