Chicago White Sox vs Washington Nationals Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Washington Nationals

Date: Saturday, September 27, 2025

Location: Nationals Park in Washington, D.C.

TV: MASN

Odds/Point Spread: Chicago (+132) Washington (-160)

Nationals Park is the location where the Washington Nationals (65-94) will try to beat the Chicago White Sox (58-100) on Saturday. The odds on this game have Chicago at +132 and Washington is at -160. The over/under has been set at 8.5. The pitchers who are expected to start will be Sean Burke and Jake Irvin.

As a unit, the Chicago White Sox are scoring 3.9 runs per outing, which has them sitting at 28th in baseball. They have notched a total of 621 runs while holding a team on-base percentage of .301. The White Sox have compiled 236 two-baggers as a team and have smacked 157 baseballs out of the park. They have accrued 600 runs batted in and 1,213 hits on the year, while their average at the plate is at .232. Chicago owns a slugging percentage of .371 and have been called out on strikes 1,326 times, while being walked on 490 occasions.

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The White Sox have compiled a team earned run average of 4.25 over the course of the season (21st in baseball), and the staff has struck out 1,242 hitters. White Sox pitchers have allowed 180 home runs and 722 runs (21st in MLB). Their pitching staff has walked 583 batters and their FIP is 4.46 as a team for the season. Chicago has conceded 1,305 hits (8.5 per 9 innings) and also 652 earned runs. They have earned a strikeout to walk ratio of 2.13 and their pitching staff has earned a collective WHIP of 1.37.

The White Sox relievers have accumulated a save percentage of 52.2% and have entered the game in 117 save situations. The bullpen pitchers have inherited 233 base runners so far this year with 31.3% of them crossed home plate. White Sox pitchers have entered the game with runners on base 159 times as well as having 150 appearances in high leverage situations. The White Sox have sent 517 relief pitchers to the hill this year. The relievers have a total of 69 holds this season (28th in baseball). They have compiled 24 saves over the course of the season and have blown 22 of 46 save opportunities.

The Chicago Cubs have a tally of 4,146 putouts at this point in the season, in addition to 1,244 assists and 98 errors. Their fielding percentage is currently at .982 which ranks 28th in the majors, and they have turned 128 double plays. The White Sox have turned 69.6% of balls in play into outs out of 12,438 innings on the diamond, which has them sitting at 19th in professional baseball.

Burke (6-11 career win-loss record) holds a FIP of 3.87 and he has gone up against 654 batters during his time in the majors. He has given up 141 hits (8.5 hits per nine innings) and has had 69 walks. His earned run average is 3.93 (65 earned runs allowed) and his career WHIP is 1.409. Burke has thrown 149 innings and has earned 145 punch outs thus far in his career.

The Washington Nationals have a team on-base percentage of .305 as well as a batting average of .242 this season. They have struck out on 1,315 occasions (16th in the league) and have earned 1,290 hits. Washington is sitting with 152 home runs so far this year as well as 642 RBIs. The Nationals have a team slugging percentage of .387 and they are recording 4.23 runs per outing (20th in MLB). They have notched 256 doubles, while getting a free base 438 times as well as scoring 672 runs.

The Nationals are sitting with a team WHIP of 1.446 and are the owners of a FIP of 4.71 as a pitching staff for the year. Their K/BB ratio comes in at 7.90 (1,218 strikeouts vs 560 walks). They come in at 29th in the league as a staff in total hits allowed with 1,459. They have conceded 207 home runs and they allow 5.65 runs per 9 innings (29th in MLB). The Washington pitching staff have relinquished 876 runs so far this year while having an ERA of 5.34 (828 earned runs relinquished).

Washington relievers hold an inherited score rate of 39.5% out of 271 inherited base runners. Their bullpen pitchers have stepped onto the mound 131 times in high leverage situations and on 163 occasions with runners on. With 130 save situations, the Nationals have earned 74 holds in addition to 19 blown saves. They are ranked 9th in the league with a save percentage of 65.5%, and they have dispatched 569 relief pitchers to the hill this year. Washington has had relievers step onto the hill in 55 save opportunities and they have tallied 36 saves.

The Washington Nationals have gotten 130 double plays and have notched a fielding percentage of .984 (23rd in baseball). The Nationals have recorded 1,376 assists, 90 errors and have a total of 4,189 putouts for the year. In 12,567 innings played, the Nationals have a defensive efficiency of 68.0% (29th in professional baseball).

During his career, Irvin has conceded 480 base hits while tallying 373 strikeouts in 482 innings pitched. He has surrendered 264 ER's while earning a WHIP of 1.342 and being the owner of a FIP of 4.9. He has a K/BB ratio of 2.23 and he has faced 2,062 hitters so far in his pro baseball career. Irvin (22-34 win-loss mark in his career) has earned a 4.93 ERA and has surrendered 9.0 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+132)

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