Chicago White Sox vs Washington Nationals Prediction, 9/28/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Washington Nationals

Date: Sunday, September 28, 2025

Location: Nationals Park in Washington, D.C.

TV: MASN

Odds/Point Spread: Chicago (+126) Washington (-152)

Nationals Park is the location where the Washington Nationals (65-94) will attempt to defeat the Chicago White Sox (58-101) on Sunday. The moneyline on this matchup has the White Sox at +126 while the Nationals open at -152. The total is 8. The starting pitchers are Shane Smith and Brad Lord.

The White Sox have tallied 237 doubles as a squad and have hit 158 baseballs out of the park. Chicago has a slugging rate of .370 and have struck out 1,334 times, while taking a walk on 492 occasions. As a unit, the Chicago White Sox are knocking in 3.9 runs per game, which puts them at 28th in MLB. They have accounted for 603 runs batted in and 1,218 base knocks on the season, and their team batting average is sitting at .231. They have earned 624 runs scored while having a team OBP of .301.

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The White Sox have a team earned run average of 4.25 on the year (21st in the league), and their staff has rung up 1,250 hitters. White Sox pitchers have surrendered 180 long balls in addition to 727 total runs (21st in MLB). They have walked 590 opposing batters and their FIP sits at 4.45 as a team for the year. Chicago has allowed 1,313 base hits (8.5 per 9 innings) in addition to 657 earned runs. They have accrued a K/BB ratio of 2.12 and the pitching staff has a team WHIP of 1.37.

The White Sox relief pitchers have recorded a save percentage of 52.2% and stepped onto the hill in 117 save situations. The relievers have inherited 235 base runners so far this season with 31.9% of them crossed home plate. White Sox relief pitchers have entered the game with players on base 160 times and also have had 151 appearances in high leverage situations. The White Sox have dispatched 520 relief pitchers to the mound this season. The bullpen have racked up 69 holds so far this season (28th in the league). They have recorded 24 saves so far this year and have blown 22 of their 46 save opportunities.

The Chicago Cubs have earned a total of 4,170 putouts on the year, as well as 1,249 assists and 98 errors. Their fielding rate is currently at .982 which ranks 28th in baseball, and they have turned 128 double plays. The White Sox have converted 69.6% of balls hit into play into outs out of their 12,510 innings, which has them ranked 19th in the majors.

Smith has taken the hill for 140 innings and is sitting with 137 strikeouts during his pro baseball career. His earned run average is 3.98 (62 earned runs allowed) and he has a WHIP of 1.242. He has given up 116 base hits (7.5 hits per nine innings) and has 58 free passes. Smith (6-8 career record) sits with a FIP of 3.92 and he has gone up against 597 hitters in the majors.

The Nationals hold a slugging percentage of .387 and they tally 4.23 runs per contest (20th in the league). They have hit 256 two-baggers, while getting a free base 438 times and scoring 672 runs. Washington has accumulated 152 home runs so far this year to go along with 642 runs batted in. They have struck out on 1,315 occasions (18th in the league) and have earned a total of 1,290 hits. The Washington Nationals have accounted for a team OBP of .305 in addition to a team batting average of .242 over the course of the season.

The Washington pitching staff have given up 876 runs on the season and come in with a team ERA of 5.34 (828 earned runs yielded). They have allowed 207 homers and they give up 5.65 runs per 9 innings (29th in baseball). The Nationals are sitting with a team WHIP of 1.446 in addition to having a FIP of 4.72 as a squad over the course of the season. Their K/BB ratio comes in at 7.90 (1,218 strikeouts against 560 walks). They are currently ranked 29th in MLB as a pitching staff in total hits conceded with 1,459.

Washington has called on relievers to enter the game in 55 save opportunities and they have walked away with 36 saves. They are ranked 9th in MLB with a save rate of 65.5%, and they have dispatched 569 relievers to the mound on the campaign. Their bullpen pitchers have stepped onto the mound 131 times in high leverage situations in addition to 163 occasions with runners on. Washington relievers have an inherited score percentage of 39.5% of 271 inherited runners. With 130 save situations, the Nationals have 74 holds and also 19 blown saves.

The Washington Nationals have gotten 130 double plays and have accounted for a fielding rate of .984 (23rd in baseball). The Nationals have 1,376 assists, 90 errors and have amassed 4,189 putouts over the course of the season. In 12,567 innings on the field, the Nationals have earned a efficiency on defense of 68.0% (29th in baseball).

Lord (5-9 career record) has a 4.14 earned run average while giving up 8.6 hits per nine innings. He has a strikeout to walk ratio of 2.54 and he has gone up against 527 opposing hitters during his career. He has given up a total of 58 ER's while earning a WHIP of 1.284 and being the owner of a FIP of 4.1. In his pro baseball career, Lord has conceded 121 base knocks and he has 104 strikeouts in 126 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+126)

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