Cincinnati Reds vs Los Angeles Dodgers Prediction, 10/1/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Los Angeles Dodgers

Date: Wednesday, October 1, 2025

Location: Dodger Stadium in Los Angeles, CA

TV: ESPN

Odds/Point Spread: Cincinnati (+220) Los Angeles (-275)

In Game 2 of the NLWC, the Los Angeles Dodgers (93-69) will take on the Cincinnati Reds (83-79) at Dodger Stadium on Wednesday. The line on this contest has the Reds at +220 while the Dodgers are coming in at -275. The over/under has been set at 8.5. The pitchers taking the mound are Zack Littell and Yoshinobu Yamamoto.

As a team, the Cincinnati Reds are scoring 4.4 runs per outing, which ranks them 14th in MLB. They have earned 716 runs scored and have an OBP of .315. The Reds have accounted for 250 two-baggers as a unit and have hit 167 baseballs out of the park. They have earned 677 RBI's as well as 1,333 hits this season, while their average at the plate is .245. Cincinnati has a slugging % of .391 and have been called out on strikes 1,415 times, while being walked on 527 occasions.

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Their strikeout to walk ratio is 2.79 and their pitching staff has earned a collective WHIP of 1.22. Reds pitchers have yielded 190 home runs and 681 total runs (11th in the league). Cincinnati has allowed 1,260 hits (7.9 per 9 innings) as well as 616 earned runs. The Reds have a team earned run average of 3.86 so far this season (11th in MLB), and their staff has struck out 1,380 batters. Their pitching staff has walked 494 opposing hitters and their FIP sits at 4.11 as a team this year.

Reds relief pitchers have stepped onto the hill with players on base 148 times in addition to having 172 appearances in high leverage situations. The relief pitchers have accumulated 104 holds on the year (6th in the league). The Reds bullpen have recorded a save percentage of 65.1% and stepped onto the hill in 170 save situations. They have compiled 41 saves on the campaign and have blown 22 of 63 save opportunities. The relief pitchers have inherited 217 base runners over the course of the season and 31.8% of them ended up crossing the plate. The Reds have dispatched 550 relief pitchers to the mound for the season.

The Reds have transformed 71.1% of baseballs in play into outs in their 12,915 innings, ranking them 4th in the majors. The Chicago White Sox have accumulated 4,305 putouts this season, in addition to 1,239 assists and 87 errors. Their fielding rate is at .985 which has them sitting 21st in professional baseball, and they have turned 101 double plays.

Littell has thrown 602 innings and has earned 496 strikeouts during his career. Littell (34-29 win-loss record in his career) has a FIP of 3.83 and he has gone up against 2,514 batters during his time in the major leagues. His ERA is 3.89 (260 ER's allowed) and his WHIP is 1.216. He has given up 597 base knocks (8.9 hits per 9 innings) and has 135 free passes.

The Dodgers have a slugging percentage of .441 and they score 5.09 runs per outing (2nd in the league). They have put up 257 two-baggers, while taking a walk 580 times as well as scoring 825 runs. Los Angeles has accumulated 244 home runs for the year as well as 791 RBIs. They have struck out on 1,353 occasions (16th in MLB) and have earned a total of 1,384 base knocks. The Los Angeles Dodgers have tallied an OBP of .327 and a team batting average of .253 for the year.

The Los Angeles pitching staff have given up 683 runs so far this year while having a team ERA of 3.95 (633 earned runs relinquished). They have yielded 175 HR's and they relinquish 4.27 runs per 9 innings (11th in the league). The Dodgers are sitting with a team WHIP of 1.258 and are the owners of a FIP of 3.93 as a pitching staff this year. They currently have a K/BB ratio of 9.40 (1,505 strikeouts against 563 free passes). They are sitting at 5th in MLB as a pitching staff in total hits relinquished with 1,250.

Los Angeles has had bullpen pitchers enter the contest in 73 save chances and they have earned 46 saves. They rank 18th in baseball with a save rate of 63.0%, and they have dispatched 581 relievers onto the field this season. Their bullpen pitchers have stepped onto the hill 186 times in high leverage situations and on 149 occasions with base runners. Los Angeles relief pitchers have an inherited score rate of 26.1% out of their 230 inherited runners. Sitting with 206 save situations, the Dodgers have amassed 128 holds in addition to 27 blown saves.

In their 12,969 innings on the field, the Dodgers have earned a efficiency on defense of 70.4% (11th in pro baseball). The Los Angeles Dodgers have turned 102 double plays and own a fielding percentage of .988 (6th in baseball). The Dodgers have 1,346 assists, 68 errors and have 4,323 putouts this season.

During his MLB career, Yamamoto has given up 191 base hits while earning 306 punch outs in 263 frames. He has given up a total of 78 earned runs while earning a WHIP of 1.033 and being the owner of a FIP of 2.6. He has a strikeout to walk ratio of 3.78 and he has gone up against 1,052 hitters so far in his MLB career. Yamamoto (19-10 record in his career) has earned a 2.67 ERA while surrendering 6.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Los Angeles (-275) and under 8.5 runs

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