Cincinnati Reds vs Milwaukee Brewers Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Milwaukee Brewers

Date: Friday, September 26, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Cincinnati (+102) Milwaukee (-122)

American Family Field is the site where the Milwaukee Brewers (96-63) will take on the Cincinnati Reds (80-78) on Friday. The odds on this game have Cincinnati at +102 while Milwaukee is at -122. The total is 8. The pitchers taking the mound will be Zack Littell and Quinn Priester.

As a squad, the Cincinnati Reds are notching 4.4 runs per game, which puts them at 14th in MLB. They have a total of 702 runs scored while holding a team on-base percentage of .315. The Reds have recorded 244 two-baggers as a team and have hit 164 baseballs out of the stadium. They have earned 664 runs batted in and 1,299 hits on the season, while their batting average is at .244. Cincinnati has a slugging rate of .392 and have been called out on strikes 1,377 times, while taking a walk on 515 occasions.

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Their strikeout to walk ratio is 2.78 and the pitching staff holds a collective WHIP of 1.23. Reds pitchers have allowed 188 long balls and also 671 runs in total (12th in MLB). Cincinnati has relinquished 1,240 base hits (8.0 per 9 innings) and 606 earned runs. The Reds hold a team earned run average of 3.90 this year (14th in the league), and their staff has rung up 1,338 batters. They have walked 481 opposing players and their FIP sits at 4.14 as a squad on the season.

The Reds relief pitchers have earned a save rate of 63.3% and have entered the game in 161 save situations. The relievers have inherited 213 runners for the season and 32.4% of those players ended up crossing the plate. Reds bullpen pitchers have come into the game with runners on 145 times as well as having 166 appearances in high leverage situations. The Reds have dispatched 535 relief pitchers to the mound on the year. The relievers are sitting with 98 holds this season (7th in the league). They have earned 38 saves this season and have not converted 22 of 60 chances to save the game.

The Reds have turned 71.0% of baseballs in play into outs in their 12,600 innings, which has them ranked 4th in professional baseball. The Chicago White Sox have a total of 4,200 putouts this year, as well as 1,215 assists and 85 errors. Their fielding percentage sits at .985 which has them ranked 22nd in pro baseball, and have accumulated 99 double plays.

Littell has thrown 598 innings and is sitting with 493 punch outs during his career. Littell (34-29 record in his career) is the owner of a FIP of 3.84 while facing 2,494 opposing hitters in the majors. His ERA is 3.90 (259 earned runs allowed) and his career WHIP is 1.216. He has conceded 594 base knocks (8.9 hits per 9 innings) and has 133 walks.

Milwaukee has accounted for 164 HRs for the year to go along with 741 runs batted in. They have recorded 258 two-baggers, while taking a walk 552 times as well as putting up 797 runs. The Milwaukee Brewers have recorded an OBP of .333 and a team batting average of .260 for the year. The Brewers hold a team SLG% of .405 and they score 5.01 runs per contest (3rd in the league). They have been called out on strikes on 1,238 occasions (26th in MLB) and have notched a total of 1,406 base knocks.

The Brewers have a team WHIP of 1.227 and have a FIP of 3.92 as a unit so far this season. They rank 3rd in baseball as a pitching staff in total hits relinquished with 1,213. The Milwaukee pitching staff have conceded 622 runs for the year while holding an ERA of 3.61 (568 earned runs given up). Their strikeout to walk ratio comes in at 8.90 (1,402 strikeouts vs 523 walks). They have conceded 165 dingers and they relinquish 3.96 runs per 9 innings (3rd in baseball).

Sitting with 173 save situations, the Brewers have tallied 104 holds in addition to 21 blown saves. Milwaukee has had relief pitchers step onto the mound in 65 save chances and they have walked away with 44 saves. Their relievers have stepped onto the mound 185 times in high leverage situations in addition to 142 occasions with runners on base. Milwaukee relief pitchers hold an inherited score percentage of 30.7% of 212 inherited base runners. They rank 6th in the league holding a save rate of 67.7%, and they have dispatched 538 relievers to the hill on the campaign.

In their 12,735 innings on the field, the Brewers are sitting with a defensive efficiency of 70.9% (5th in baseball). The Milwaukee Brewers have turned 119 double plays and own a fielding percentage of .987 (9th in pro baseball). The Brewers have racked up 1,277 assists, 73 errors and have amassed 4,245 putouts during this campaign.

Priester (19-11 win-loss record in his career) has a 4.44 earned run average and has surrendered 9.0 hits per 9 innings. He has a strikeout to walk ratio of 2.19 and he has faced 1,085 opposing batters so far in his MLB career. He has surrendered 124 ER's while earning a WHIP of 1.353 and being the owner of a FIP of 4.4. In his MLB career, Priester has given up 250 base knocks while he has tallied 197 punch outs in 251 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+102)

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