Cincinnati Reds vs San Diego Padres Prediction, 9/10/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs San Diego Padres

Date: Wednesday, September 10, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Cincinnati (+220) San Diego (-275)

The San Diego Padres (79-65) are hosting the Cincinnati Reds (72-72) at Petco Park on Wednesday. The moneyline on this contest has the Reds at +220 while the Padres are at -275. The over/under comes in at 8. The starting pitchers will be Andrew Abbott and Nick Pivetta.

The Reds have accumulated 233 doubles as a unit and have hit 143 baseballs out of the park. Cincinnati is slugging .392 and have struck out 1,256 times, while being walked on 470 occasions. As a squad, the Cincinnati Reds are notching 4.5 runs per game, which ranks them 13th in baseball. They have compiled 614 runs batted in and 1,199 base knocks this season, and their average at the plate sits at .247. They have 650 runs and have an OBP of .317.

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The Reds have a team ERA of 3.94 this season (16th in baseball), and their staff has struck out 1,224 batters. Reds pitchers have allowed 170 home runs in addition to 621 runs in total (16th in MLB). They have walked 451 players from the other team and their FIP sits at 4.15 as a team over the course of the season. Cincinnati has given up 1,139 hits (8.0 per 9 innings) in addition to 559 earned runs. They have accumulated a K/BB ratio of 2.71 and the pitching staff holds a collective WHIP of 1.25.

Reds bullpen pitchers have entered the contest with runners on base 130 times as well as having 150 appearances in high leverage situations. The relievers have earned 91 holds on the year (6th in MLB). The Reds relievers have a save percentage of 61.1% and have entered the game in 147 save situations. They have earned 33 saves on the campaign and have blown 21 out of their 54 chances to get a save. The relievers have inherited 193 runners for the season and 33.2% of them ended up scoring. The Reds have dispatched 495 relievers to the mound on the year.

The Reds have turned 70.7% of baseballs in play into outs in their 11,484 innings, which has them sitting 6th in MLB. The Chicago White Sox have a tally of 3,828 putouts at this point in the season, as well as 1,092 assists and 82 errors. Their fielding percentage is holding steady at .984 which puts them in 25th in MLB, and they have turned 92 double plays.

Abbott has taken the ball for 390 frames and is sitting with 364 punch outs so far in his career. His earned run average is 3.46 (150 ER's allowed) and his WHIP is 1.250. He has conceded 352 hits (8.1 hits per nine innings) and has had 136 free passes. Abbott (26-22 win-loss mark in his career) is the owner of a FIP of 3.41 while he has faced 1,636 batters in the major leagues.

The San Diego Padres have earned a team OBP of .322 in addition to a batting average of .252 over the course of the season. They have struck out on 1,022 occasions (28th in the league) and have recorded 1,217 hits. San Diego has accounted for 127 HRs over the course of the season to go along with 577 RBIs. The Padres have a team SLG% of .387 and they score 4.26 runs per game (22nd in baseball). They have put up 236 doubles, while getting a free base 463 times and scoring 614 runs.

The San Diego pitching staff have given up 559 runs on the season while holding a team ERA of 3.66 (517 earned runs surrendered). They have relinquished 154 homers and they allow 3.96 runs per 9 innings (4th in MLB). The Padres have a WHIP of 1.212 and are the owners of a FIP of 4.01 as a team over the course of the season. Their strikeout to walk ratio is 8.80 (1,245 strikeouts vs 474 free passes). They are sitting at 1st in the league as a staff in total hits allowed with 1,068.

San Diego relievers hold an inherited score percentage of 28.8% out of their 233 inherited runners. Their relievers have come in 191 times in high leverage situations in addition to 164 occasions with runners on base. Sitting with 155 save situations, the Padres have amassed 91 holds and 15 blown saves. They are ranked 1st in baseball with a save rate of 74.6%, and they have sent 510 relief pitchers to the hill on the season. San Diego has called on bullpen pitchers to enter the game in 59 save opportunities and they have walked away with 44 saves.

The San Diego Padres have turned 105 double plays and have earned a fielding percentage of .987 (13th in professional baseball). The Padres have racked up 1,088 assists, 66 errors and have accumulated 3,816 putouts this year. In their 11,448 innings on the diamond, the Padres have a efficiency on defense of 71.7% (2nd in professional baseball).

During his MLB career, Pivetta has allowed 1,092 base hits while he has earned 1,311 strikeouts in 1,193 frames. He has surrendered 596 earned runs while holding a WHIP of 1.268 and having a FIP of 4.4. His K/BB ratio is 3.11 and he has gone up against 5,035 opposing batters during his career. Pivetta (69-76 career record) is the owner of a 4.50 ERA while giving up 8.2 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+220)

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