Cincinnati Reds vs St. Louis Cardinals Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Tuesday, September 16, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Cincinnati (-160) St. Louis (+132)

The Cincinnati Reds (74-75) are headed to Busch Stadium on Tuesday where they will meet the St. Louis Cardinals (73-77). The moneyline on this contest has the Reds at -160 and the Cardinals are sitting at +132. The total has been set at 9. The starting pitchers will be Andrew Abbott and Michael McGreevy.

Cincinnati has a slugging rate of .391 and have struck out 1,295 times, while drawing a walk on 489 occasions. They have tallied 629 runs batted in and 1,232 base knocks on the season, and their team batting average is at .246. The Reds have tallied 233 two-baggers as a team and have smacked 151 baseballs out of the park. They have a total of 665 runs while holding a team on-base percentage of .316. As a team, the Cincinnati Reds are recording 4.5 runs per game, which has them sitting at 14th in the league.

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The Reds have compiled a team earned run average of 3.98 this year (15th in MLB), and they have rung up 1,259 batters. Reds pitchers have surrendered 181 home runs and also 645 total runs (15th in MLB). They have walked 464 players from the other team and their FIP is 4.21 as a unit on the campaign. Cincinnati has conceded 1,176 hits (8.0 per 9 innings) as well as 583 earned runs. They have earned a strikeout to walk ratio of 2.71 and their pitching staff has a collective WHIP of 1.24.

The Reds have sent 507 relievers to the mound so far this year. The bullpen pitchers have inherited 202 runners this year and 33.2% of them ended up scoring. They have earned 35 saves so far this season and have blown 21 of their 56 chances to save the game. The Reds relief pitchers have earned a save percentage of 62.5% and have stepped onto the mound in 149 save situations. The bullpen have 91 holds for the year (9th in baseball). Reds bullpen pitchers have gone to the mound with players on base 135 times and also have had 156 appearances in high leverage situations.

The Reds have turned 70.9% of balls hit into play into outs out of their 11,862 innings, which has them ranked 4th in the majors. The Chicago White Sox have earned a total of 3,954 putouts over the course of the season, in addition to 1,140 assists and 82 errors. Their fielding percentage is holding at .984 which puts them in 23rd in MLB, and have a total of 94 double plays.

Abbott (27-22 career mark) has earned a FIP of 3.36 and he has faced 1,666 batters in the majors. He has conceded 357 base hits (8.1 hits per 9 innings) and has 138 free passes. His ERA is 3.41 (151 earned runs allowed) and he has a career WHIP of 1.243. Abbott has pitched in 398 frames and has 370 strikeouts in his career.

The Cardinals have a slugging percentage of .379 and they tally 4.28 runs per contest (19th in the league). They have recorded 238 two-baggers, while taking a walk 446 times and notching 642 runs. St. Louis has a total of 140 HRs for the year to go along with 610 RBIs. They have struck out on 1,212 occasions (22nd in the league) and have 1,233 base hits. The St. Louis Cardinals have accumulated a team OBP of .314 and a team batting average of .245 for the season.

The Cardinals have a team WHIP of 1.319 and have a FIP of 4.05 as a pitching staff so far this season. They currently have a strikeout to walk ratio of 7.50 (1,109 strikeouts against 427 walks). They have a ranking of 26th in baseball as a staff in total hits allowed with 1,323. They have allowed 154 long balls and they relinquish 4.71 runs per 9 innings (21st in baseball). The St. Louis pitching staff have allowed 694 runs this season and come in with a team ERA of 4.28 (631 earned runs relinquished).

St. Louis has had bullpen pitchers take the mound in 60 save opportunities and they have converted 39 saves. They rank 12th in the league holding a save rate of 65.0%, and they have dispatched 445 relievers to the hill on the campaign. Their relief pitchers have stepped onto the mound 145 times in high leverage situations and on 145 occasions with runners on base. St. Louis relief pitchers have an inherited score rate of 32.8% out of 201 inherited runners. Sitting with 149 save situations, the Cardinals have accumulated 85 holds and also 21 blown saves.

The St. Louis Cardinals have gotten 119 double plays and have accounted for a fielding rate of .987 (12th in the majors). The Cardinals have accrued 1,441 assists, 73 errors and have a tally of 3,981 putouts so far this season. Out of their 11,943 innings played, the Cardinals have accumulated a efficiency on defense of 69.0% (22nd in MLB).

During his career, McGreevy has given up 101 hits while totaling 65 punch outs in 102 innings pitched. McGreevy (9-3 career mark) has a 3.88 ERA and has conceded 8.9 hits per 9 innings. He has allowed 44 earned runs while holding a WHIP of 1.127 and having a FIP of 3.8. He has a K/BB ratio of 4.64 and he has faced 416 opposing hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-160)

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