Cleveland Guardians vs Arizona Diamondbacks Prediction, 8/20/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Arizona Diamondbacks

Date: Wednesday, August 20, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Cleveland (-122) Arizona (+102)

Chase Field is the location where the Arizona Diamondbacks (60-66) will take on the Cleveland Guardians (64-60) on Wednesday. The line on this matchup has the Guardians at -122 while the Diamondbacks are sitting at +102. The total has been set at 8.5. The men taking the mound will be Slade Cecconi and Brandon Pfaadt.

The Guardians have tallied 184 two-baggers as a squad and have hit 131 balls out of the park. Cleveland owns a slugging percentage of .375 and have been called out on strikes 1,012 times, while being walked on 389 occasions. As a squad, the Cleveland Guardians are scoring 4.0 runs per game, which is 26th in the league. They have recorded 472 runs batted in as well as 924 base knocks for the year, while their team batting average is at .227. They have tallied 491 runs scored while holding a team on-base percentage of .299.

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The Guardians have a team ERA of 3.86 for the year (12th in the league), and the staff has rung up 1,044 hitters. Guardians pitchers have conceded 132 long balls in addition to 523 runs (12th in the league). Their pitching staff has walked 442 players from the other team and their FIP sits at 4.10 as a unit so far this season. Cleveland has conceded 1,006 base hits (8.2 per 9 innings) and also 474 earned runs. Their strikeout to walk ratio is 2.36 and the pitching staff has a collective WHIP of 1.31.

The Guardians relief pitchers have earned a save percentage of 69.8% and have entered the game in 144 save situations. The relievers have inherited 156 runners on the year and 33.3% of those runners ended up scoring. Guardians relief pitchers have come into the game with players on base 110 times as well as having 143 appearances in high leverage situations. The Guardians have dispatched 416 relievers to the hill over the course of the season. The relief pitchers have earned 88 holds on the year (2nd in the league). They have earned 37 saves on the campaign and have blown 16 out of their 53 save chances.

The Cincinnati Reds have accumulated 3,314 putouts this season, as well as 1,011 assists and 83 errors. Their fielding percentage is currently at .981 which has them ranked 28th in baseball, and have a total of 91 double plays. The Guardians have turned 69.5% of balls hit into play into outs in their 9,942 innings on the field, which has them ranked 19th in baseball.

Cecconi has pitched in 194 innings and has totaled 160 strikeouts thus far in his career. Cecconi (7-14 record in his career) is the owner of a FIP of 5.26 and he has faced 834 batters in the major leagues. His ERA is 5.34 (115 ER's allowed) and his WHIP is 1.335. He has given up 212 base hits (9.8 hits per 9 innings) and has 47 walks.

The Diamondbacks have a slugging percentage of .439 and they score 4.91 runs per contest (6th in baseball). They have recorded 220 doubles, while walking 435 times and recording 619 runs. Arizona has tallied 176 long balls this year and 604 runs batted in. They have struck out on 999 occasions (21st in MLB) and have accounted for 1,068 base knocks. The Arizona Diamondbacks are sitting with an OBP of .326 as well as a batting average of .250 this year.

The Arizona pitching staff have conceded 616 runs on the season while having a team ERA of 4.57 (568 earned runs yielded). They have surrendered 156 dingers and they relinquish 4.95 runs per 9 innings (25th in the league). The Diamondbacks have a team WHIP of 1.336 in addition to having a FIP of 4.31 as a unit on the season. Their strikeout to walk ratio is 8.10 (1,012 strikeouts against 392 bases on balls). They are sitting at 26th in baseball as a staff in total hits allowed with 1,103.

Sitting with 123 save situations, the Diamondbacks have earned 62 holds in addition to 24 blown saves. Arizona has called on bullpen pitchers to enter the game in 57 save chances and they have walked away with 33 saves. Their relievers have taken the field 115 times in high leverage situations and on 103 occasions with runners on base. Arizona relief pitchers hold an inherited score percentage of 32.6% out of 132 inherited base runners. They are ranked 23rd in baseball holding a save rate of 57.9%, and they have dispatched 381 bullpen pitchers to the mound this season.

In 10,071 innings played, the Diamondbacks are sitting with a defensive efficiency of 69.1% (23rd in pro baseball). The Arizona Diamondbacks have gotten 96 double plays and have notched a fielding percentage of .986 (17th in pro baseball). The Diamondbacks have recorded 1,117 assists, 63 errors and have earned a total of 3,357 putouts so far this season.

During his MLB career, Pfaadt has given up 443 base knocks and he has 387 strikeouts in 410 frames. He has surrendered a total of 231 ER's while earning a WHIP of 1.319 and having a FIP of 5.0. He has a strikeout to walk ratio of 3.95 and he has gone up against 1,763 opposing hitters so far in his MLB career. Pfaadt (26-27 career mark) has a 5.07 ERA while conceding 9.7 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Arizona (+102) and under 8.5 runs

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