Cleveland Guardians vs Boston Red Sox Prediction, 9/2/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Boston Red Sox

Date: Tuesday, September 2, 2025

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Cleveland (+132) Boston (-160)

The Boston Red Sox (75-62) will try to beat the Cleveland Guardians (68-66) at Fenway Park on Tuesday. The moneyline on this contest has Cleveland at +132 and Boston is opening at -160. The over/under comes in at 8.5. The pitchers expected to start will be Slade Cecconi and Brayan Bello.

As a team, the Cleveland Guardians are scoring 3.9 runs per outing, which has them at 28th in baseball. They have a total of 517 runs while holding a team OBP of .295. The Guardians have accrued 191 doubles as a unit and have smacked 136 baseballs out of the park. They have compiled 498 RBI's and 980 base knocks on the campaign, while their average at the plate is .224. Cleveland has a slugging rate of .367 and have been called out on strikes 1,109 times, while being walked on 412 occasions.

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Their strikeout to walk ratio sits at 2.39 and the pitching staff holds a WHIP of 1.31. Guardians pitchers have surrendered 148 home runs in addition to 570 runs (11th in baseball). Cleveland has conceded 1,092 base knocks (8.2 per 9 innings) as well as 519 earned runs. The Guardians are sitting with a team ERA of 3.92 on the campaign (14th in MLB), and their staff has struck out 1,117 batters. They have walked 467 players from the other team and their FIP is 4.15 as a team over the course of the season.

The Guardians have sent 445 relievers to the mound this season. The relievers have inherited 170 runners for the season with 33.5% of those runners crossed the plate. They have 39 saves so far this year and have blown 18 of their 57 save opportunities. The Guardians relievers have a save percentage of 68.4% and stepped onto the hill in 152 save situations. The bullpen have racked up 92 holds so far this season (3rd in the league). Guardians bullpen pitchers have entered the contest with runners on 122 times as well as having 153 appearances in high leverage situations.

The Guardians have turned 69.6% of balls in play into outs out of 10,728 innings on the field, which ranks them 19th in baseball. The Cincinnati Reds have a tally of 3,576 putouts so far this season, in addition to 1,094 assists and 86 errors. Their fielding percentage is currently at .982 which is 27th in pro baseball, and they have turned 98 double plays.

Cecconi has taken the hill for 206 frames and has racked up 167 strikeouts in his career. His ERA is 5.24 (120 ER's allowed) and he has a career WHIP of 1.306. He has allowed 222 hits (9.7 hits per nine innings) and has had 47 walks. Cecconi (7-14 career win-loss mark) has earned a FIP of 5.16 and he has faced 879 batters during his time in the major leagues.

The Red Sox have a team slugging % of .424 and they have an average of 4.91 runs per contest (6th in baseball). They have hit 272 doubles, while taking a walk 446 times as well as notching 673 runs. Boston has accounted for 165 home runs so far this year and 642 RBIs. They have struck out on 1,209 instances (4th in the league) and have tallied 1,184 base hits. The Boston Red Sox are sitting with an OBP of .323 as well as a batting average of .252 over the course of the season.

The Red Sox are sitting with a team WHIP of 1.287 and have a FIP of 3.99 as a pitching staff over the course of the season. Their K/BB ratio comes in at 8.30 (1,136 strikeouts against 450 bases on balls). They are currently ranked 19th in the league as a staff in total hits allowed with 1,129. They have relinquished 138 homers and they concede 4.21 runs per 9 innings (9th in baseball). The Boston pitching staff have yielded 574 runs on the year while having an ERA of 3.70 (504 earned runs conceded).

Boston relievers have an inherited score percentage of 32.1% of 184 inherited base runners. Their bullpen pitchers have stepped onto the hill 166 times in high leverage situations and also on 137 occasions with base runners. Sitting with 136 save situations, the Red Sox have earned 72 holds in addition to 24 blown saves. They sit at 20th in baseball with a save percentage of 61.3%, and they have dispatched 448 relievers onto the diamond this season. Boston has had relief pitchers step onto the mound in 62 save chances and they have earned 38 saves.

In their 11,043 innings played, the Red Sox are sitting with a efficiency on defense of 69.1% (23rd in baseball). The Boston Red Sox have turned 112 double plays and hold a fielding percentage of .980 (29th in professional baseball). The Red Sox have accrued 1,254 assists, 103 errors and have 3,681 putouts this season.

Bello (38-33 career record) is the owner of a 4.04 ERA and has conceded 9.1 hits per nine innings. His strikeout to walk ratio is 2.45 and he has gone up against 2,226 batters so far in his pro baseball career. He has given up 232 ER's while earning a WHIP of 1.361 and having a FIP of 4.0. So far in his MLB career, Bello has allowed 521 base hits while he has accumulated 448 K's in 517 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (+132)

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