Cleveland Guardians vs Cincinnati Reds Prediction, 5/16/2025 MLB Picks, Best Bets & Odds
Game: Cleveland Guardians vs Cincinnati Reds
Date: Friday, May 16, 2025
Location: Great American Ball Park in Cincinnati, OH
TV: FanDuel Sports Network Ohio
Odds/Point Spread: Cleveland (-130) Cincinnati (+110)
Great American Ball Park is the location where the Cincinnati Reds (20-24) will try to defeat the Cleveland Guardians (25-18) on Friday. The line on this contest has Cleveland at -130 and Cincinnati is at +110. The total is set at 8. The starting pitchers will be Tanner Bibee and Brady Singer.


As a unit, the Cleveland Guardians are scoring 4.1 runs per contest, which puts them at 20th in MLB. They have 176 runs while holding a team OBP of .308. The Guardians have hit 56 two-baggers as a team and have hit 48 balls out of the stadium. They have accrued 165 RBI's and 324 hits for the season, and their team batting average is at .233. Cleveland has a slugging % of .381 and have been rung up 341 times, while drawing a walk on 142 occasions.
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They have earned a K/BB ratio of 2.23 and the pitching staff holds a WHIP of 1.41. Guardians pitchers have conceded 47 home runs in addition to 190 runs (18th in baseball). Cleveland has allowed 374 base hits (8.9 per 9 innings) in addition to 175 earned runs. The Guardians are sitting with a team earned run average of 4.14 over the course of the season (21st in MLB), and the staff has struck out 361 hitters. Their pitching staff has walked 162 players from the other team and their FIP comes in at 4.18 as a team over the course of the season.
Guardians relief pitchers have stepped onto the hill with opponents on base 36 times as well as having 44 appearances in high leverage situations. The relievers have racked up 38 holds over the course of the season (1st in the league). The Guardians bullpen have a save percentage of 73.7% and have come into the game in 57 save situations. They have recorded 14 saves for the year and have missed out on 5 of their 19 chances to save the game. The relief pitchers have inherited 52 runners for the season with 32.7% of those runners crossed the plate. The Guardians have dispatched 151 relief pitchers to the mound so far this season.
The Cincinnati Reds have a tally of 1,140 putouts at this point in the season, as well as 324 assists and 28 errors. Their fielding percentage is at .981 which has them ranked 26th in the majors, and have a total of 34 double plays. The Guardians have converted 67.6% of balls hit into play into outs in their 3,420 innings on the field, ranking them 28th in the majors.
Bibee has pitched in 360 frames and has tallied 359 strikeouts during his pro baseball career. His ERA is 3.32 (133 earned runs allowed) and his WHIP is 1.155. He has conceded 311 hits (7.8 hits per nine innings) and has 105 free passes. Bibee (25-15 career win-loss mark) holds a FIP of 3.27 while he has faced 1,480 opposing hitters in the majors.
Cincinnati has a total of 44 home runs this season as well as 194 RBIs. They have notched 73 two-baggers, while walking 161 times and notching 201 runs. The Cincinnati Reds have earned an on-base percentage of .318 and a batting average of .236 so far this season. The Reds hold a slugging percentage of .379 and they have an average of 4.57 runs per game (13th in the league). They have been called out on strikes on 398 occasions (4th in the league) and have accounted for 350 base hits.
The Reds hold a team WHIP of 1.189 and have a FIP of 4.09 as a unit for the year. They are currently ranked 7th in the league as a staff in total hits conceded with 328. The Cincinnati pitching staff have given up 183 runs for the year and come in with a team ERA of 3.75 (163 earned runs relinquished). Their K/BB ratio sits at 8.60 (374 strikeouts against 137 walks). They have conceded 52 homers and they concede 4.21 runs per 9 innings (13th in the league).
Cincinnati has called on relievers to enter the game in 17 save chances and they have walked away with 11 saves. They sit at 13th in baseball holding a save percentage of 64.7%, and they have dispatched 147 relief pitchers onto the diamond for the season. Their relief pitchers have stepped onto the hill 43 times in high leverage situations in addition to 33 occasions with runners on. Cincinnati bullpen pitchers have an inherited score rate of 31.4% out of their 51 inherited base runners. With 48 save situations, the Reds have accrued 29 holds and 6 blown saves.
The Cincinnati Reds have turned 19 double plays and hold a fielding percentage of .985 (19th in baseball). The Reds have accrued 327 assists, 23 errors and have a total of 1,173 putouts this year. In their 3,519 innings on the diamond, the Reds have accumulated a defensive efficiency of 72.5% (2nd in baseball).
Thus far in his career, Singer has conceded 735 base knocks while accumulating 684 punch outs in 726 innings pitched. He has given up a total of 349 ER's while earning a WHIP of 1.327 and having a FIP of 4.3. His K/BB ratio is 2.99 and he has faced 3,112 hitters so far in his career. Singer (40-46 record in his career) has a 4.32 ERA while allowing 9.1 hits per 9 innings.
Who will win tonight's MLB game against the spread or moneyline?
Tony Sink's Pick: Take Cleveland (-130)
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Additional Resources:
Cincinnati Reds - Twitter
Cleveland Guardians - Twitter