Cleveland Guardians vs Minnesota Twins Prediction, 9/20/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Minnesota Twins

Date: Saturday, September 20, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Cleveland (-152) Minnesota (+126)

The Minnesota Twins (66-86) will go up against the Cleveland Guardians (80-71) at Target Field on Saturday. The line on this matchup has Cleveland at -152 while Minnesota is coming in at +126. The total has been set at 8. The starting pitchers will be Parker Messick and Joe Ryan.

The Guardians have hit 223 two-baggers as a unit and have hit 155 balls out of the stadium. Cleveland has a slugging rate of .371 and have been rung up 1,248 times, while taking a walk on 461 occasions. As a unit, the Cleveland Guardians are compiling 3.9 runs per game, which has them at 27th in MLB. They have 571 runs batted in in addition to 1,115 hits so far this season, and their team batting average is at .225. They have a total of 591 runs scored and have an on-base percentage of .296.

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The Guardians hold a team earned run average of 3.77 over the course of the season (5th in baseball), and they have rung up 1,258 hitters. Guardians pitchers have surrendered 160 home runs and 616 runs (6th in baseball). They have walked 504 opposing batters and their FIP comes in at 4.06 as a squad this year. Cleveland has conceded 1,219 base knocks (8.2 per 9 innings) and 562 earned runs. They have accrued a K/BB ratio of 2.50 and the pitching staff has earned a collective WHIP of 1.28.

Guardians bullpen pitchers have entered the game with runners on base 141 times and also have had 179 appearances in high leverage situations. The relievers have tallied 106 holds over the course of the season (3rd in the league). The Guardians bullpen have recorded a save percentage of 69.2% and have entered the game in 174 save situations. They have accumulated 45 saves on the campaign and have not converted 20 out of their 65 save chances. The relief pitchers have inherited 193 runners over the course of the season and 32.6% of them crossed the plate. The Guardians have sent 497 relievers to the hill so far this season.

The Guardians have turned 69.8% of baseballs in play into outs in their 12,087 innings on the field, which has them sitting 17th in the majors. The Cincinnati Reds have earned 4,029 putouts for the season, in addition to 1,252 assists and 93 errors. Their fielding percentage is holding steady at .983 which puts them in 27th in MLB, and they have turned 114 double plays.

Messick has taken the hill for 29 frames and has totaled 22 strikeouts so far in his MLB career. His earned run average is 1.86 (6 ER's allowed) and he has a career WHIP of 1.340. He has surrendered 35 base hits (10.8 hits per 9 innings) with 4 free passes. Messick (3-0 win-loss record in his career) holds a FIP of 1.83 and he has faced 120 opposing batters in the majors.

The Twins have a SLG% of .400 and they are recording 4.30 runs per game (18th in the league). They have 234 doubles, while getting a free base 473 times as well as scoring 653 runs. Minnesota has recorded 182 home runs so far this year as well as 619 runs batted in. They have been rung up on 1,262 occasions (16th in baseball) and have accounted for 1,228 base knocks. The Minnesota Twins have tallied a team on-base percentage of .314 in addition to a team batting average of .240 this year.

The Twins hold a team WHIP of 1.336 in addition to having a FIP of 4.16 as a squad so far this year. They are currently ranked 28th in MLB as a pitching staff in total hits relinquished with 1,350. The Minnesota pitching staff have relinquished 741 runs for the season while having an ERA of 4.65 (692 earned runs conceded). Their K/BB ratio comes in at 8.60 (1,278 strikeouts vs 437 walks). They have conceded 184 HR's and they give up 4.98 runs per 9 innings (25th in baseball).

Minnesota relief pitchers have an inherited score percentage of 35.4% of 164 inherited runners. Their bullpen pitchers have taken the field 165 times in high leverage situations and on 114 occasions with runners on. With 143 save situations, the Twins have amassed 90 holds in addition to 24 blown saves. They are currently ranked 28th in the league holding a save percentage of 52.9%, and they have dispatched 515 relievers to the hill this season. Minnesota has had relievers take the mound in 51 save opportunities and they have tallied 27 saves.

In 12,042 innings played, the Twins have accumulated a defensive efficiency of 68.1% (29th in MLB). The Minnesota Twins have turned 92 double plays and hold a fielding percentage of .985 (18th in pro baseball). The Twins have recorded 1,146 assists, 78 errors and have amassed 4,014 putouts on the season.

Ryan (46-34 record in his career) has earned a 3.78 earned run average while allowing 7.5 hits per 9 innings. He has a K/BB ratio of 4.86 and he has faced 2,560 opposing hitters so far in his career. He has allowed 265 earned runs while holding a WHIP of 1.060 and being the owner of a FIP of 3.7. During his pro baseball career, Ryan has surrendered 524 base knocks while accumulating 705 punch outs in 631 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Minnesota (+126)

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