Detroit Tigers vs Cleveland Guardians Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Detroit Tigers vs Cleveland Guardians

Date: Tuesday, September 23, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Detroit (-128) Cleveland (+106)

The Detroit Tigers (85-71) are hitting the road to Progressive Field on Tuesday where they will meet the Cleveland Guardians (84-72). The odds on this game have Detroit at -128 and Cleveland opens at +106. The betting total is set at 8. The pitchers taking the mound are Tarik Skubal and Gavin Williams.

Detroit has a slugging rate of .417 and have been called out on strikes 1,374 times, while being walked on 486 occasions. They have 707 runs batted in and 1,291 base knocks this season, and their batting average is at .247. The Tigers have recorded 236 two-baggers as a team and have knocked 193 baseballs out of the stadium. They are sitting with 741 runs while having a team on-base percentage of .316. As a squad, the Detroit Tigers are earning 4.8 runs per outing, which has them sitting at 9th in the league.

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The Tigers are sitting with a team earned run average of 3.97 for the season (15th in baseball), and the staff has rung up 1,311 batters. Tigers pitchers have surrendered 183 home runs in addition to 664 runs in total (14th in the league). Their pitching staff has walked 464 opposing hitters and their FIP sits at 4.11 as a unit for the year. Detroit has allowed 1,254 base hits (8.2 per 9 innings) as well as 607 earned runs. They have a strikeout to walk ratio of 2.83 and the pitching staff holds a collective WHIP of 1.25.

The Tigers bullpen have accumulated a save percentage of 64.4% and have entered the game in 134 save situations. The bullpen pitchers have inherited 241 base runners this season and 27.8% of those runners crossed home plate. Tigers pitchers have entered the contest with runners on base 171 times in addition to having 133 appearances in high leverage situations. The Tigers have sent 482 relief pitchers to the hill this year. The bullpen have accumulated 71 holds so far this season (24th in baseball). They have earned 38 saves on the year and have missed out on 21 of 59 chances to save the game.

The Tigers have converted 70.3% of balls in play into outs out of 12,393 innings, which has them sitting 12th in professional baseball. The Colorado Rockies have accounted for 4,131 putouts this year, in addition to 1,332 assists and 75 errors. Their fielding percentage is at .986 which ranks 13th in professional baseball, and have 125 double plays.

Skubal (54-36 career mark) sits with a FIP of 3.04 while he has gone up against 3,032 batters in the majors. He has surrendered 610 base hits (7.2 hits per nine innings) and has had 169 free passes. His ERA is 3.09 (261 ER's allowed) and he has a career WHIP of 1.025. Skubal has thrown 760 frames and has accumulated 881 K's during his pro baseball career.

The Cleveland Guardians are sitting with an OBP of .297 as well as a batting average of .227 over the course of the season. They have been called out on strikes on 1,283 occasions (17th in MLB) and have totaled 1,153 base hits. Cleveland has 162 HRs for the year to go along with 593 RBIs. The Guardians have a team SLG% of .374 and they score 3.96 runs per game (27th in MLB). They have put up 231 two-baggers, while getting a free base 475 times as well as earning 614 runs.

The Cleveland pitching staff have allowed 619 runs so far this year while holding a team ERA of 3.69 (565 earned runs given up). They have relinquished 160 homers and they allow 4.04 runs per 9 innings (5th in baseball). The Guardians hold a team WHIP of 1.269 and are the owners of a FIP of 3.99 as a unit for the season. They have earned a K/BB ratio of 8.50 (1,303 strikeouts vs 513 bases on balls). They rank 11th in the league as a staff in total hits surrendered with 1,237.

Sitting with 178 save situations, the Guardians have accrued 108 holds in addition to 21 blown saves. Cleveland has had relief pitchers take the mound in 67 save opportunities and they have tallied 46 saves. Their relief pitchers have stepped onto the mound 184 times in high leverage situations in addition to 142 occasions with runners on base. Cleveland relief pitchers hold an inherited score rate of 33.0% of 194 inherited base runners. They are ranked 6th in MLB with a save percentage of 68.7%, and they have sent 505 relief pitchers to the hill on the year.

In their 12,411 innings played, the Guardians have earned a defensive efficiency of 69.8% (18th in pro baseball). The Cleveland Guardians have gotten 120 double plays and have a fielding rate of .983 (27th in professional baseball). The Guardians have accrued 1,287 assists, 95 errors and are sitting with 4,137 putouts for the year.

In his career, Williams has surrendered 264 base knocks while he has accumulated 321 K's in 319 innings pitched. Williams (17-20 win-loss record in his career) has earned a 3.55 earned run average while giving up 7.4 hits per 9 innings. He has conceded 126 earned runs while holding a WHIP of 1.297 and having a FIP of 3.5. He has a K/BB ratio of 2.14 and he has faced 1,357 batters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cleveland (+106)

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