Detroit Tigers vs Cleveland Guardians Prediction, 9/24/2025 MLB Picks, Best Bets & Odds

Game: Detroit Tigers vs Cleveland Guardians

Date: Wednesday, September 24, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Detroit (-145) Cleveland (+125)

Progressive Field is the location where the Cleveland Guardians (84-72) will go up against the Detroit Tigers (85-71) on Wednesday. The moneyline on this game has the Tigers at -145 and the Guardians are priced at +125. The total comes in at 8. The expected starting pitchers are Jack Flaherty and Tanner Bibee.

Detroit owns a slugging percentage of .417 and have struck out 1,384 times, while drawing a walk on 491 occasions. They have 709 RBI's as well as 1,302 hits this season, and their batting average comes in at .248. The Tigers have hit 239 two-baggers as a team and have smacked 193 baseballs out of the stadium. They have earned 743 runs while holding a team OBP of .317. As a unit, the Detroit Tigers are notching 4.8 runs per outing, which is 9th in the league.

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Their strikeout to walk ratio is 2.80 and their pitching staff has a collective WHIP of 1.25. Tigers pitchers have allowed 184 home runs in addition to 670 runs in total (15th in MLB). Detroit has allowed 1,265 hits (8.2 per 9 innings) as well as 613 earned runs. The Tigers are sitting with a team ERA of 3.98 on the year (16th in MLB), and the staff has rung up 1,318 hitters. Their pitching staff has walked 471 hitters and their FIP comes in at 4.11 as a squad over the course of the season.

The Tigers relievers have earned a save rate of 64.4% and have stepped onto the mound in 134 save situations. The relief pitchers have inherited 245 runners on the campaign with 28.2% of them ended up crossing the plate. Tigers bullpen pitchers have entered the game with players on base 173 times in addition to having 133 appearances in high leverage situations. The Tigers have sent 487 relief pitchers to the mound over the course of the season. The bullpen have recorded 71 holds so far this year (24th in the league). They have earned 38 saves on the season and have blown 21 out of their 59 save opportunities.

The Colorado Rockies are sitting with 4,158 putouts thus far, as well as 1,338 assists and 75 errors. Their fielding percentage sits at .987 which is 12th in the majors, and they have turned 125 double plays. The Tigers have turned 70.3% of balls in play into outs in their 12,474 innings on the diamond, which has them ranked 12th in baseball.

Flaherty has taken the hill for 985 innings and has totaled 1,124 punch outs so far in his career. Flaherty (63-55 career win-loss record) has earned a FIP of 3.73 while he has faced 4,101 batters during his time in the majors. His ERA is 3.79 (415 earned runs allowed) and he has a WHIP of 1.200. He has conceded 831 hits (7.6 hits per 9 innings) and has had 351 walks.

Cleveland has compiled 163 HRs so far this season to go along with 595 RBIs. They have 231 two-baggers, while taking a walk 477 times and recording 616 runs. The Cleveland Guardians are sitting with an on-base percentage of .297 as well as a batting average of .226 on the year. The Guardians hold a slugging percentage of .373 and they are earning 3.95 runs per contest (27th in baseball). They have been rung up on 1,289 occasions (18th in MLB) and have recorded 1,157 base knocks.

The Guardians are sitting with a team WHIP of 1.270 and are the owners of a FIP of 3.99 as a pitching staff on the year. They sit at 11th in MLB as a pitching staff in total hits surrendered with 1,247. The Cleveland pitching staff have allowed 625 runs over the course of the season while holding an ERA of 3.71 (571 earned runs relinquished). They have earned a strikeout to walk ratio of 8.50 (1,313 strikeouts vs 515 bases on balls). They have given up 162 HR's and they allow 4.06 runs per 9 innings (5th in the league).

Cleveland relievers hold an inherited score percentage of 33.5% of 200 inherited runners. Their relievers have come in 187 times in high leverage situations and on 145 occasions with base runners. With 179 save situations, the Guardians have compiled 108 holds and 22 blown saves. They rank 5th in the league with a save rate of 67.6%, and they have sent 510 relievers to the mound over the course of the season. Cleveland has had relievers step onto the hill in 68 save opportunities and they have walked away with 46 saves.

The Cleveland Guardians have gotten 120 double plays and own a fielding percentage of .983 (27th in the majors). The Guardians have accrued 1,292 assists, 96 errors and have accounted for 4,161 putouts this season. In their 12,483 innings played, the Guardians hold a defensive efficiency of 69.8% (16th in the majors).

Bibee (33-23 mark in his career) has earned a 3.65 earned run average while allowing 8.0 hits per nine innings. His K/BB ratio is 3.44 and he has gone up against 2,033 batters in his MLB career. He has given up a total of 199 earned runs while earning a WHIP of 1.176 and a FIP of 3.6. In his MLB career, Bibee has allowed 437 hits while he has earned 485 strikeouts in 491 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cleveland (+125)

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