Detroit Tigers vs St. Louis Cardinals Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Detroit Tigers vs St. Louis Cardinals

Date: Wednesday, May 21, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Detroit (-145) St. Louis (+125)

The Detroit Tigers (31-17) are on their way to Busch Stadium on Wednesday where they will meet the St. Louis Cardinals (27-21). The odds on this game have Detroit at -145 and St. Louis is coming in at +125. The over/under is 9. The expected starting pitchers are Brant Hurter and Andre Pallante.

Detroit is slugging .422 and have been called out on strikes 423 times, while taking a walk on 163 occasions. They have tallied 245 RBI's in addition to 426 base knocks on the year, and their batting average comes in at .260. The Tigers have tallied 72 doubles as a squad and have hit 60 balls out of the park. They have a total of 257 runs scored and have an on-base percentage of .332. As a squad, the Detroit Tigers are earning 5.4 runs per game, which has them sitting at 4th in baseball.

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The Tigers have compiled a team earned run average of 3.36 on the year (6th in baseball), and the staff has struck out 415 hitters. Tigers pitchers have yielded 52 home runs in addition to 177 runs (8th in baseball). Their pitching staff has walked 141 opposing hitters and their FIP comes in at 3.88 as a squad on the year. Detroit has surrendered 363 hits (7.7 per 9 innings) as well as 159 earned runs. They have a strikeout to walk ratio of 2.94 and the pitching staff has earned a collective WHIP of 1.18.

The Tigers bullpen have a save percentage of 68.4% and have stepped onto the mound in 40 save situations. The relievers have inherited 65 runners on the campaign with 29.2% of them earned a run for their team. Tigers relief pitchers have come into the game with runners on 47 times and also have had 37 appearances in high leverage situations. The Tigers have sent 140 relief pitchers to the hill so far this year. The relievers have a total of 19 holds on the campaign (26th in MLB). They have compiled 13 saves on the year and have blown 6 of their 19 chances to save the game.

The Tigers have turned 71.5% of balls in play into outs out of their 3,834 innings on the field, which ranks them 7th in baseball. The Colorado Rockies have amassed 1,278 putouts this year, in addition to 420 assists and 21 errors. Their fielding percentage sits at .988 which is 10th in pro baseball, and they have turned 36 double plays.

Hurter (7-1 career win-loss mark) has earned a FIP of 2.47 while he has faced 263 opposing hitters in the major leagues. He has surrendered 51 base hits (6.7 hits per 9 innings) and has had 11 walks. His ERA is 2.51 (19 earned runs allowed) and his WHIP is 0.910. Hurter has taken the mound for 68 frames and has racked up 59 K's during his MLB career.

The St. Louis Cardinals are sitting with a team OBP of .337 and a batting average of .266 for the season. They have been called out on strikes on 362 occasions (23rd in MLB) and have totaled 437 base hits. St. Louis has accumulated 46 HRs for the year to go along with 221 RBIs. The Cardinals hold a team SLG% of .409 and they are scoring 4.90 runs per game (6th in baseball). They have put up 96 doubles, while taking a walk 163 times and scoring 235 runs.

The Cardinals have a WHIP of 1.221 with a FIP of 3.63 as a team so far this season. Their K/BB ratio comes in at 7.20 (342 strikeouts against 139 walks). They have a ranking of 14th in the league as a staff in total hits relinquished with 380. They have given up 35 home runs and they concede 4.02 runs per 9 innings (12th in MLB). The St. Louis pitching staff have given up 190 runs this season while having an ERA of 3.68 (174 earned runs surrendered).

St. Louis has called on bullpen pitchers to step onto the hill in 19 save chances and they have walked away with 12 saves. They are ranked 18th in MLB holding a save percentage of 63.2%, and they have sent 142 bullpen pitchers to the hill this year. Their bullpen pitchers have stepped onto the mound 61 times in high leverage situations and on 44 occasions with runners on. St. Louis relief pitchers hold an inherited score percentage of 36.2% out of 58 inherited base runners. With 53 save situations, the Cardinals have earned 33 holds and 7 blown saves.

Out of their 3,831 innings on the diamond, the Cardinals hold a defensive efficiency of 71.4% (8th in professional baseball). The St. Louis Cardinals have gotten 34 double plays and hold a fielding percentage of .990 (1st in the majors). The Cardinals have recorded 476 assists, 17 errors and are sitting with 1,277 putouts this season.

In his pro baseball career, Pallante has conceded 350 base knocks while he has earned 242 punch outs in 347 frames. He has allowed 148 ER's while earning a WHIP of 1.394 and being the owner of a FIP of 3.8. His strikeout to walk ratio is 1.81 and he has faced 1,481 batters thus far in his career. Pallante (22-16 career mark) has earned a 3.84 ERA and has given up 9.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take St. Louis (+125) and under 9 runs

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