Houston Astros vs Los Angeles Angels Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Los Angeles Angels

Date: Friday, September 26, 2025

Location: Angel Stadium in Anaheim, CA

TV: FanDuel Sports Network West

Odds/Point Spread: Houston (-128) Los Angeles (+106)

The Los Angeles Angels (71-87) welcome the Houston Astros (84-74) at Angel Stadium on Friday. The moneyline on this contest has the Astros at -128 and the Angels open at +106. The betting total comes in at 9. The expected starting pitchers will be Jason Alexander and Kyle Hendricks.

The Astros have compiled 239 doubles as a unit and have hit 172 balls out of the park. Houston owns a slugging percentage of .396 and have been rung up 1,263 times, while drawing a walk on 458 occasions. As a team, the Houston Astros are scoring 4.2 runs per game, which has them sitting at 25th in the league. They have accumulated 630 runs batted in as well as 1,336 base knocks for the season, and their team batting average sits at .250. They have 660 runs while having a team OBP of .315.

Get all of our Free MLB Picks

The Astros hold a team ERA of 3.88 this year (12th in the league), and their staff has struck out 1,468 hitters. Astros pitchers have surrendered 194 home runs in addition to 653 total runs (9th in baseball). They have walked 495 opposing players and their FIP comes in at 4.02 as a squad for the year. Houston has allowed 1,228 base hits (7.9 per 9 innings) in addition to 607 earned runs. They have earned a strikeout to walk ratio of 2.97 and the pitching staff holds a collective WHIP of 1.22.

The Astros have sent 506 relievers to the hill this year. The bullpen pitchers have inherited 177 runners this year and 23.2% of those players crossed the plate. They have tallied 45 saves this season and have not converted 16 of 61 chances to get a save. The Astros relief pitchers have earned a save percentage of 73.8% and have come into the game in 152 save situations. The relievers have a total of 88 holds on the campaign (15th in the league). Astros relief pitchers have come into the game with runners on base 127 times in addition to having 166 appearances in high leverage situations.

The Astros have turned 70.7% of balls in play into outs out of their 12,663 innings, which has them sitting at 9th in the majors. The Detroit Tigers have a total of 4,221 putouts thus far, as well as 1,248 assists and 68 errors. Their fielding rate is holding steady at .988 which is 8th in professional baseball, and they have turned 102 double plays.

Alexander has thrown 143 frames and is sitting with 107 strikeouts so far in his pro baseball career. Alexander (6-5 career mark) holds a FIP of 5.07 and he has faced 639 opposing hitters in the major leagues. His ERA is 5.15 (82 earned runs allowed) and his WHIP is 1.513. He has allowed 164 base hits (10.3 hits per 9 innings) and has had 53 free passes.

Los Angeles has hit 220 home runs on the campaign as well as 638 RBIs. They have put up 209 two-baggers, while walking 474 times as well as putting up 662 runs. The Los Angeles Angels have tallied an on-base percentage of .299 and a team batting average of .226 this season. The Angels hold a slugging percentage of .398 and they score 4.19 runs per outing (24th in baseball). They have struck out on 1,590 occasions (1st in the league) and have tallied 1,185 base hits.

The Angels hold a team WHIP of 1.436 in addition to having a FIP of 4.76 as a pitching staff so far this season. They are sitting at 26th in the league as a staff in total hits surrendered with 1,394. The Los Angeles pitching staff have yielded 813 runs for the season and come in with a team ERA of 4.86 (754 earned runs relinquished). Their strikeout to walk ratio comes in at 8.00 (1,243 strikeouts vs 610 walks). They have allowed 213 homers and they concede 5.24 runs per 9 innings (28th in baseball).

Los Angeles has had relief pitchers take the mound in 71 save chances and they have come away with 37 saves. They are ranked 30th in baseball with a save percentage of 52.1%, and they have sent 543 relievers onto the field this season. Their bullpen pitchers have stepped onto the mound 204 times in high leverage situations in addition to 140 occasions with runners on. Los Angeles bullpen pitchers hold an inherited score percentage of 37.7% of 212 inherited base runners. With 156 save situations, the Angels have earned 82 holds and 34 blown saves.

The Los Angeles Angels have gotten 158 double plays and have a fielding percentage of .983 (26th in professional baseball). The Angels have racked up 1,382 assists, 94 errors and have 4,186 putouts during this campaign. In their 12,558 innings played, the Angels have earned a defensive efficiency of 68.8% (24th in professional baseball).

Hendricks (105-91 record in his career) has a 3.79 earned run average and has conceded 8.6 hits per nine innings. His K/BB ratio is 3.35 and he has gone up against 7,191 batters during his pro baseball career. He has given up a total of 732 ER's while earning a WHIP of 1.190 and a FIP of 3.7. So far in his MLB career, Hendricks has given up 1,663 base hits while accumulating 1,365 K's in 1,739 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Houston (-128)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here