Houston Astros vs Los Angeles Angels Prediction, 9/28/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Los Angeles Angels

Date: Sunday, September 28, 2025

Location: Angel Stadium in Anaheim, CA

TV: FanDuel Sports Network West

Odds/Point Spread: Houston (-275) Los Angeles (+220)

The Los Angeles Angels (71-88) are hosting the Houston Astros (85-74) at Angel Stadium on Sunday. The odds on this game have Houston at -275 and Los Angeles is at +220. The over/under is 9. The pitchers taking the mound are Cristian Javier and Sam Aldegheri.

As a squad, the Houston Astros are notching 4.2 runs per game, which has them sitting at 21st in the league. They have 671 runs and have an OBP of .316. The Astros have accrued 243 doubles as a unit and have smacked 173 baseballs out of the stadium. They have tallied 641 runs batted in in addition to 1,348 hits this year, while their team batting average sits at .250. Houston has a slugging % of .396 and have struck out 1,273 times, while drawing a walk on 465 occasions.

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They have earned a strikeout to walk ratio of 2.97 and the pitching staff holds a collective WHIP of 1.23. Astros pitchers have surrendered 196 home runs and also 658 runs in total (9th in the league). Houston has conceded 1,240 base hits (7.9 per 9 innings) in addition to 612 earned runs. The Astros are sitting with a team earned run average of 3.89 over the course of the season (14th in the league), and their staff has rung up 1,480 batters. They have walked 498 opposing players and their FIP is 4.03 as a team on the season.

The Astros relief pitchers have earned a save percentage of 73.8% and stepped onto the hill in 152 save situations. The relief pitchers have inherited 179 base runners on the year with 23.5% of those players earned a run for their team. Astros pitchers have gone to the mound with players on base 128 times and also have had 166 appearances in high leverage situations. The Astros have sent 509 relievers to the mound on the year. The relievers have recorded 88 holds this season (15th in MLB). They have earned 45 saves so far this season and have missed out on 16 out of their 61 save opportunities.

The Astros have converted 70.6% of balls in play into outs out of 12,744 innings, which has them ranked 10th in pro baseball. The Detroit Tigers have amassed 4,248 putouts on the year, as well as 1,260 assists and 69 errors. Their fielding percentage is currently at .988 which puts them in 8th in pro baseball, and have 103 double plays.

Javier has taken the mound for 538 innings and has accumulated 598 strikeouts during his pro baseball career. His ERA is 3.66 (219 ER's allowed) and he has a career WHIP of 1.145. He has allowed 397 hits (6.6 hits per nine innings) and has 219 free passes. Javier (35-22 career record) sits with a FIP of 3.61 while facing 2,217 opposing batters in the major leagues.

The Angels have a team slugging % of .398 and they are earning 4.19 runs per contest (24th in baseball). They have recorded 209 doubles, while taking a walk 474 times as well as scoring 666 runs. Los Angeles has a total of 223 home runs for the year to go along with 642 RBIs. They have struck out on 1,603 instances (1st in the league) and have a total of 1,192 base hits. The Los Angeles Angels have compiled an OBP of .298 as well as a team batting average of .226 this season.

The Angels have a WHIP of 1.438 and have a FIP of 4.76 as a pitching staff this year. They are currently ranked 26th in MLB as a pitching staff in total hits relinquished with 1,405. The Los Angeles pitching staff have surrendered 822 runs on the campaign and come in with a team ERA of 4.89 (763 earned runs yielded). Their K/BB ratio is 8.00 (1,252 strikeouts against 614 walks). They have surrendered 214 homers and they surrender 5.27 runs per 9 innings (28th in baseball).

Sitting with 156 save situations, the Angels have accrued 82 holds and also 34 blown saves. Los Angeles has had bullpen pitchers step onto the mound in 71 save chances and they have walked away with 37 saves. Their relief pitchers have stepped onto the mound 204 times in high leverage situations in addition to 140 occasions with runners on base. Los Angeles bullpen pitchers hold an inherited score rate of 37.7% out of 212 inherited base runners. They rank 30th in the league with a save rate of 52.1%, and they have sent 546 relievers to the mound this year.

In 12,639 innings played, the Angels are sitting with a defensive efficiency of 68.8% (24th in baseball). The Los Angeles Angels have turned 158 double plays and hold a fielding percentage of .983 (26th in pro baseball). The Angels have recorded 1,388 assists, 94 errors and have earned 4,213 putouts so far this season.

So far in his career, Aldegheri has allowed 28 base hits while tallying 17 strikeouts in 22 frames. Aldegheri (1-3 career mark) has earned a 6.14 earned run average and has given up 11.5 hits per nine innings. He has allowed 15 ER's while holding a WHIP of 2.045 and having a FIP of 6.0. His strikeout to walk ratio is 1.00 and he has faced 115 hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Houston (-275)

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