Houston Astros vs Pittsburgh Pirates Prediction, 6/4/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Pittsburgh Pirates

Date: Wednesday, June 4, 2025

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: Houston (-182) Pittsburgh (+150)

PNC Park is where the Pittsburgh Pirates (22-38) will try to defeat the Houston Astros (32-27) on Wednesday. The moneyline on this contest has the Astros at -182 and the Pirates are priced at +150. The total is set at 8. The men taking the mound will be Ryan Gusto and Mike Burrows.

The Astros have earned 80 doubles as a unit and have smacked 59 baseballs out of the park. Houston is slugging .391 and have struck out 449 times, while being walked on 172 occasions. As a team, the Houston Astros are knocking in 4.1 runs per contest, which has them sitting at 24th in the league. They have accrued 228 runs batted in and 497 hits on the year, and their team batting average comes in at .254. They have accounted for 239 runs and have an on-base percentage of .321.

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They have earned a K/BB ratio of 3.03 and their pitching staff has earned a collective WHIP of 1.17. Astros pitchers have surrendered 59 home runs in addition to 224 runs (10th in MLB). Houston has allowed 423 base hits (7.3 per 9 innings) and 211 earned runs. The Astros are sitting with a team ERA of 3.66 on the year (11th in MLB), and their staff has struck out 560 batters. They have walked 185 opposing players and their FIP is 3.58 as a squad on the year.

The Astros have sent 184 relievers to the mound so far this season. The relief pitchers have inherited 68 base runners on the season with 30.9% of them crossed home plate. They have accumulated 16 saves on the year and have blown 6 of their 22 chances to save the game. The Astros relievers have a save rate of 72.7% and have entered the game in 58 save situations. The relievers have accumulated 36 holds over the course of the season (12th in MLB). Astros relief pitchers have stepped onto the hill with runners on base 46 times and also have had 52 appearances in high leverage situations.

The Detroit Tigers have accounted for 1,558 putouts on the campaign, in addition to 440 assists and 24 errors. Their fielding percentage is holding steady at .988 which is 10th in pro baseball, and have a total of 33 double plays. The Astros have turned 71.4% of balls in play into outs in their 4,674 innings, which has them sitting at 6th in pro baseball.

Gusto (3-2 career win-loss record) holds a FIP of 4.55 while he has faced 178 hitters during his time in the major leagues. He has conceded 42 hits (9.7 hits per nine innings) and has had 19 walks. His earned run average is 4.62 (20 ER's allowed) and he has a WHIP of 1.564. Gusto has taken the mound for 39 frames and has tallied 42 strikeouts in his career.

The Pittsburgh Pirates are sitting with an on-base percentage of .306 in addition to a batting average of .227 this year. They have been called out on strikes on 524 occasions (6th in the league) and have notched a total of 454 base hits. Pittsburgh has tallied 43 home runs this year and 188 runs batted in. The Pirates hold a team SLG% of .340 and they are recording 3.23 runs per game (29th in MLB). They have notched 75 two-baggers, while walking 208 times and earning 194 runs.

The Pittsburgh pitching staff have relinquished 252 runs so far this season while holding a team ERA of 3.96 (234 earned runs relinquished). They have relinquished 48 dingers and they relinquish 4.26 runs per 9 innings (15th in the league). The Pirates hold a team WHIP of 1.246 in addition to having a FIP of 3.82 as a squad this year. They currently have a K/BB ratio of 7.40 (436 strikeouts vs 190 walks). They come in at 14th in the league as a pitching staff in total hits conceded with 473.

Pittsburgh has had bullpen pitchers enter the game in 24 save chances and they have come away with 12 saves. They are ranked 28th in the league with a save percentage of 50.0%, and they have dispatched 197 relief pitchers onto the field for the year. Their relievers have stepped onto the mound 67 times in high leverage situations in addition to 59 occasions with runners on base. Pittsburgh relief pitchers have an inherited score percentage of 37.9% of 95 inherited base runners. Sitting with 57 save situations, the Pirates have tallied 32 holds in addition to 12 blown saves.

In 4,788 innings on the diamond, the Pirates hold a efficiency on defense of 70.9% (9th in professional baseball). The Pittsburgh Pirates have turned 53 double plays and own a fielding percentage of .985 (21st in baseball). The Pirates have accrued 541 assists, 33 errors and have earned 1,596 putouts this year.

Burrows (1-1 career win-loss mark) has earned a 7.23 ERA while conceding 8.8 hits per nine innings. His K/BB ratio is 1.00 and he has gone up against 53 batters during his pro baseball career. He has given up 9 ER's while holding a WHIP of 1.607 and a FIP of 7.1. During his pro baseball career, Burrows has allowed 11 base knocks and he has 7 punch outs in 11 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Pittsburgh (+150)

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