Los Angeles Angels vs Colorado Rockies Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Angels vs Colorado Rockies

Date: Sunday, September 21, 2025

Location: Coors Field in Denver, CO

TV: Rockies.TV

Odds/Point Spread: Los Angeles (-122) Colorado (+102)

The Colorado Rockies (41-112) will play the Los Angeles Angels (69-84) at Coors Field on Sunday. The line on this contest has the Angels at -122 while the Rockies are priced at +102. The total comes in at 8.5. The pitchers taking the mound are Kyle Hendricks and German Marquez.

As a squad, the Los Angeles Angels are notching 4.2 runs per game, which is 25th in baseball. They have accumulated 645 runs scored while holding a team OBP of .300. The Angels have hit 204 doubles as a team and have hit 212 balls out of the stadium. They have tallied 623 RBI's and 1,151 hits so far this year, and their average at the plate is sitting at .226. Los Angeles is slugging .398 and have been called out on strikes 1,540 times, while drawing a walk on 463 occasions.

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The Angels have a team earned run average of 4.89 on the campaign (28th in baseball), and they have rung up 1,203 hitters. Angels pitchers have relinquished 211 home runs and also 793 runs (28th in the league). Their pitching staff has walked 595 opposing players and their FIP comes in at 4.82 as a team on the season. Los Angeles has conceded 1,358 base knocks (9.0 per 9 innings) as well as 735 earned runs. Their strikeout to walk ratio is 2.02 and their pitching staff holds a collective WHIP of 1.44.

The Angels bullpen have recorded a save percentage of 50.7% and have entered the game in 150 save situations. The relief pitchers have inherited 209 runners on the year and 37.8% of those runners ended up crossing the plate. Angels relief pitchers have stepped onto the hill with runners on 138 times as well as having 201 appearances in high leverage situations. The Angels have sent 528 relievers to the mound this year. The relievers have 78 holds this year (21st in MLB). They have recorded 35 saves so far this year and have blown 34 of 69 chances to save the game.

The Angels have turned 68.8% of baseballs in play into outs out of their 12,099 innings on the field, ranking them 25th in professional baseball. The Kansas City Royals have amassed 4,033 putouts this year, as well as 1,321 assists and 91 errors. Their fielding rate is currently at .983 which has them ranked 26th in MLB, and they have turned 152 double plays.

Hendricks (104-91 record in his career) has a FIP of 3.75 while facing 7,167 opposing hitters in the majors. He has conceded 1,660 base hits (8.6 hits per nine innings) and has 407 walks. His ERA is 3.80 (732 ER's allowed) and his WHIP is 1.193. Hendricks has thrown 1,732 frames and has accumulated 1,360 strikeouts during his pro baseball career.

The Rockies hold a team slugging percentage of .390 and they score 3.75 runs per game (29th in MLB). They have hit 243 two-baggers, while walking 376 times and racking up 574 runs. Colorado has compiled 154 home runs on the year as well as 559 RBIs. They have been called out on strikes on 1,439 occasions (2nd in MLB) and have a total of 1,227 hits. The Colorado Rockies have recorded an OBP of .296 and a batting average of .239 for the year.

The Colorado pitching staff have given up 978 runs so far this season and come in with a team ERA of 6.04 (894 earned runs relinquished). They have allowed 234 long balls and they give up 6.61 runs per 9 innings (30th in the league). The Rockies have a WHIP of 1.599 and have a FIP of 5.23 as a unit so far this season. Their strikeout to walk ratio is 6.90 (1,015 strikeouts against 525 free passes). They are sitting at 30th in baseball as a staff in total hits given up with 1,605.

Sitting with 104 save situations, the Rockies have recorded 53 holds and also 24 blown saves. Colorado has called on relievers to enter the contest in 51 save opportunities and they have come away with 27 saves. Their relievers have taken the field 131 times in high leverage situations and on 156 occasions with runners on. Colorado bullpen pitchers hold an inherited score percentage of 34.8% of 267 inherited base runners. They are ranked 27th in the league with a save percentage of 52.9%, and they have dispatched 503 relievers onto the diamond so far this season.

The Colorado Rockies have turned 146 double plays and have a fielding percentage of .981 (29th in professional baseball). The Rockies have recorded 1,391 assists, 106 errors and have accumulated 3,970 putouts so far this year. Out of their 11,910 innings played, the Rockies have accumulated a defensive efficiency of 65.8% (30th in MLB).

During his career, Marquez has given up 1,165 base hits while he has accumulated 1,063 K's in 1,135 innings pitched. He has conceded 586 earned runs while earning a WHIP of 1.335 and being the owner of a FIP of 4.6. His strikeout to walk ratio is 3.04 and he has faced 4,859 opposing batters during his career. Marquez (68-70 career win-loss mark) holds a 4.65 ERA while giving up 9.2 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-122)

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