Los Angeles Angels vs Milwaukee Brewers Prediction, 9/17/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Angels vs Milwaukee Brewers

Date: Wednesday, September 17, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Los Angeles (+220) Milwaukee (-275)

American Family Field is the site where the Milwaukee Brewers (91-59) will try to beat the Los Angeles Angels (69-81) on Wednesday. The line on this contest has Los Angeles at +220 while Milwaukee is priced at -275. The over/under comes in at 8. The pitchers who are expected to start are Jose Soriano and Brandon Woodruff.

Los Angeles owns a slugging percentage of .399 and have been rung up 1,496 times, while drawing a walk on 459 occasions. They have earned 617 runs batted in as well as 1,137 hits so far this season, while their team batting average sits at .228. The Angels have recorded 202 doubles as a team and have hit 207 balls out of the stadium. They have earned 639 runs while holding a team on-base percentage of .302. As a squad, the Los Angeles Angels are recording 4.3 runs per outing, which has them at 23rd in the league.

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The Angels have compiled a team ERA of 4.83 for the year (28th in the league), and their staff has rung up 1,186 hitters. Angels pitchers have surrendered 209 home runs and also 770 total runs (28th in MLB). Their pitching staff has walked 578 opposing batters and their FIP sits at 4.82 as a squad this year. Los Angeles has allowed 1,330 base hits (9.0 per 9 innings) and also 713 earned runs. They have a strikeout to walk ratio of 2.05 and their pitching staff has a collective WHIP of 1.44.

The Angels relievers have a save percentage of 51.5% and stepped onto the hill in 149 save situations. The relief pitchers have inherited 204 runners on the year and 36.8% of them crossed home plate. Angels bullpen pitchers have come into the game with runners on 136 times as well as having 198 appearances in high leverage situations. The Angels have sent 519 relief pitchers to the hill for the season. The relievers have racked up 78 holds for the year (21st in MLB). They have tallied 35 saves over the course of the season and have blown 33 of their 68 save opportunities.

The Kansas City Royals have accounted for 3,985 putouts at this point in the season, in addition to 1,311 assists and 90 errors. Their fielding percentage is at .983 which is 26th in pro baseball, and have accumulated 151 double plays. The Angels have transformed 68.8% of balls in play into outs out of 11,955 innings on the diamond, ranking them 24th in baseball.

Soriano (17-20 career record) sits with a FIP of 3.77 and he has gone up against 1,370 hitters in the major leagues. He has conceded 280 base knocks (7.8 hits per nine innings) and has had 144 free passes. His earned run average is 3.83 (137 ER's allowed) and he has a WHIP of 1.316. Soriano has pitched in 322 innings and has earned 305 punch outs during his career.

Milwaukee is sitting with 160 home runs so far this year to go along with 707 runs batted in. They have notched 243 doubles, while taking a walk 516 times as well as recording 762 runs. The Milwaukee Brewers have accounted for an on-base percentage of .333 as well as a team batting average of .260 on the year. The Brewers have a team slugging % of .408 and they are scoring 5.08 runs per contest (3rd in MLB). They have been rung up on 1,170 occasions (26th in the league) and have tallied 1,330 base knocks.

The Brewers have a WHIP of 1.236 with a FIP of 3.93 as a team so far this season. They sit at 3rd in baseball as a pitching staff in total hits surrendered with 1,151. The Milwaukee pitching staff have surrendered 589 runs on the season while having an ERA of 3.63 (538 earned runs allowed). Their K/BB ratio sits at 8.90 (1,317 strikeouts against 498 bases on balls). They have relinquished 154 HR's and they surrender 3.97 runs per 9 innings (3rd in baseball).

With 165 save situations, the Brewers have accumulated 100 holds and 19 blown saves. Milwaukee has called on bullpen pitchers to enter the contest in 61 save opportunities and they have walked away with 42 saves. Their relievers have taken the field 170 times in high leverage situations in addition to 133 occasions with runners on base. Milwaukee relievers have an inherited score percentage of 30.5% out of their 197 inherited runners. They sit at 5th in the league with a save rate of 68.9%, and they have sent 507 relief pitchers onto the diamond for the season.

The Milwaukee Brewers have turned 111 double plays and hold a fielding percentage of .987 (9th in the majors). The Brewers have 1,202 assists, 68 errors and have a tally of 4,004 putouts for the year. In their 12,012 innings played, the Brewers have a defensive efficiency of 70.8% (6th in the majors).

Woodruff (52-28 win-loss mark in his career) is the owner of a 3.12 earned run average and has given up 7.0 hits per nine innings. His strikeout to walk ratio is 4.54 and he has faced 2,966 opposing batters in his pro baseball career. He has given up 256 earned runs while holding a WHIP of 1.039 and a FIP of 3.1. So far in his career, Woodruff has given up 578 base knocks while tallying 862 strikeouts in 739 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Milwaukee (-275)

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