Los Angeles Dodgers vs Arizona Diamondbacks Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs Arizona Diamondbacks

Date: Tuesday, September 23, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Los Angeles (-128) Arizona (+106)

The Arizona Diamondbacks (79-77) host the Los Angeles Dodgers (88-68) at Chase Field on Tuesday. The odds on this game have Los Angeles at -128 while Arizona is at +106. The total is 8. The starting pitchers will be Shohei Ohtani and Brandon Pfaadt.

The Dodgers have accrued 248 two-baggers as a squad and have hit 232 balls out of the stadium. Los Angeles is slugging .441 and have struck out 1,288 times, while taking a walk on 564 occasions. As a unit, the Los Angeles Dodgers are knocking in 5.1 runs per contest, which is 2nd in the league. They have accounted for 760 runs batted in in addition to 1,329 hits this year, and their team batting average sits at .254. They have notched a total of 793 runs while holding a team on-base percentage of .330.

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The Dodgers are sitting with a team earned run average of 4.03 on the campaign (18th in MLB), and they have struck out 1,423 batters. Dodgers pitchers have surrendered 173 home runs and 665 runs in total (15th in MLB). They have walked 544 opposing batters and their FIP comes in at 4.03 as a squad for the year. Los Angeles has allowed 1,201 base hits (7.9 per 9 innings) in addition to 616 earned runs. Their strikeout to walk ratio is 2.62 and their pitching staff holds a collective WHIP of 1.27.

The Dodgers bullpen have compiled a save rate of 63.6% and have entered the game in 191 save situations. The relief pitchers have inherited 221 runners on the season with 25.8% of those runners earned a run for their team. Dodgers relief pitchers have entered the game with runners on 142 times in addition to having 171 appearances in high leverage situations. The Dodgers have dispatched 552 relief pitchers to the mound on the year. The bullpen have notched 120 holds this season (1st in baseball). They have tallied 42 saves so far this season and have blown 24 of their 66 chances to save the game.

The Dodgers have converted 70.4% of balls hit into play into outs out of 12,387 innings on the field, which ranks them 11th in the majors. The Los Angeles Angels have a tally of 4,129 putouts on the campaign, as well as 1,294 assists and 66 errors. Their fielding percentage is at .988 which has them ranked 6th in MLB, and have 99 double plays.

Ohtani has thrown 522 innings and has totaled 662 strikeouts during his career. His earned run average is 3.03 (176 earned runs allowed) and he has a WHIP of 1.082. He has surrendered 383 base hits (6.6 hits per 9 innings) with 182 walks. Ohtani (39-20 career record) is the owner of a FIP of 2.99 while he has gone up against 2,117 opposing hitters in the majors.

Arizona has compiled 206 HRs on the year to go along with 743 RBIs. They have recorded 266 two-baggers, while getting a free base 519 times and recording 764 runs. The Arizona Diamondbacks have accounted for an on-base percentage of .324 as well as a batting average of .251 over the course of the season. The Diamondbacks have a team SLG% of .434 and they earn 4.93 runs per contest (4th in MLB). They have been rung up on 1,247 occasions (23rd in the league) and have totaled 1,315 hits.

The Arizona pitching staff have given up 742 runs so far this season and come in with a team ERA of 4.45 (683 earned runs relinquished). They have surrendered 184 HR's and they relinquish 4.83 runs per 9 innings (23rd in MLB). The Diamondbacks hold a team WHIP of 1.311 with a FIP of 4.26 as a squad over the course of the season. Their strikeout to walk ratio is 8.00 (1,227 strikeouts vs 477 free passes). They sit at 24th in MLB as a pitching staff in total hits conceded with 1,335.

Arizona bullpen pitchers have an inherited score percentage of 33.9% out of 189 inherited base runners. Their bullpen pitchers have stepped onto the hill 162 times in high leverage situations and on 143 occasions with base runners. With 164 save situations, the Diamondbacks have earned 88 holds and 29 blown saves. They are ranked 22nd in the league with a save percentage of 59.2%, and they have sent 477 relievers to the mound this season. Arizona has called on bullpen pitchers to enter the contest in 71 save opportunities and they have walked away with 42 saves.

The Arizona Diamondbacks have gotten 123 double plays and hold a fielding percentage of .986 (16th in MLB). The Diamondbacks have accrued 1,393 assists, 79 errors and have a tally of 4,146 putouts this year. In 12,438 innings on the diamond, the Diamondbacks hold a defensive efficiency of 69.6% (20th in pro baseball).

During his career, Pfaadt has allowed 480 base hits while he has earned 417 K's in 443 innings. Pfaadt (27-27 career mark) is the owner of a 5.05 ERA while giving up 9.7 hits per nine innings. He has surrendered a total of 249 earned runs while holding a WHIP of 1.315 and having a FIP of 5.0. His strikeout to walk ratio is 4.05 and he has faced 1,904 hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Arizona (+106)

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