Los Angeles Dodgers vs Arizona Diamondbacks Prediction, 9/25/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs Arizona Diamondbacks

Date: Thursday, September 25, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Los Angeles (-152) Arizona (+126)

The Arizona Diamondbacks (80-77) will try to defeat the Los Angeles Dodgers (88-69) at Chase Field on Thursday. The line on this matchup has the Dodgers at -152 and the Diamondbacks open at +126. The betting total comes in at 8.5. The pitchers who are expected to start are Yoshinobu Yamamoto and Zac Gallen.

Los Angeles has a slugging percentage of .440 and have struck out 1,300 times, while being walked on 567 occasions. They have accrued 765 runs batted in and 1,341 base knocks on the season, while their average at the plate sits at .253. The Dodgers have accounted for 249 two-baggers as a team and have hit 234 balls out of the park. They have accounted for 798 runs while holding a team on-base percentage of .329. As a team, the Los Angeles Dodgers are notching 5.1 runs per game, which is 2nd in the league.

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The Dodgers have compiled a team earned run average of 4.03 this year (18th in baseball), and their staff has struck out 1,443 batters. Dodgers pitchers have yielded 174 home runs in addition to 673 total runs (13th in the league). They have walked 549 opposing batters and their FIP sits at 4.01 as a team this year. Los Angeles has relinquished 1,215 base knocks (7.8 per 9 innings) and 624 earned runs. They have a K/BB ratio of 2.63 and the pitching staff has a collective WHIP of 1.27.

The Dodgers have sent 559 relief pitchers to the hill so far this year. The bullpen pitchers have inherited 224 runners this year with 25.9% of those runners ended up crossing the plate. They have recorded 42 saves on the season and have blown 26 of their 68 chances to save the game. The Dodgers relievers have recorded a save rate of 61.8% and have come into the game in 195 save situations. The relief pitchers have earned 122 holds so far this year (1st in MLB). Dodgers relief pitchers have entered the game with opponents on base 144 times as well as having 174 appearances in high leverage situations.

The Los Angeles Angels have notched a total of 4,182 putouts so far this season, in addition to 1,307 assists and 66 errors. Their fielding percentage sits at .988 which is 6th in baseball, and they have turned 100 double plays. The Dodgers have converted 70.4% of balls in play into outs out of their 12,546 innings, which ranks them 11th in the majors.

Yamamoto (18-10 career win-loss mark) sits with a FIP of 2.69 while going up against 1,028 opposing hitters in the major leagues. He has given up 187 base hits (6.5 hits per nine innings) and has 79 free passes. His earned run average is 2.73 (78 ER's allowed) and his WHIP is 1.034. Yamamoto has taken the hill for 257 innings and has tallied 299 punch outs so far in his career.

The Diamondbacks hold a slugging % of .435 and they have an average of 4.96 runs per contest (4th in MLB). They have hit 269 doubles, while getting a free base 523 times and scoring 778 runs. Arizona is sitting with 210 home runs on the campaign as well as 757 RBIs. They have struck out on 1,262 instances (23rd in the league) and have tallied 1,339 hits. The Arizona Diamondbacks have an OBP of .325 as well as a team batting average of .252 this season.

The Diamondbacks hold a team WHIP of 1.311 and have a FIP of 4.26 as a unit for the season. They come in at 24th in the league as a pitching staff in total hits allowed with 1,351. The Arizona pitching staff have relinquished 748 runs this season while having a team ERA of 4.43 (689 earned runs allowed). They have earned a K/BB ratio of 8.00 (1,241 strikeouts vs 484 bases on balls). They have given up 186 long balls and they relinquish 4.81 runs per 9 innings (23rd in baseball).

Arizona has called on relief pitchers to enter the game in 71 save opportunities and they have walked away with 42 saves. They sit at 23rd in the league holding a save percentage of 59.2%, and they have sent 484 relievers to the mound for the season. Their relievers have stepped onto the mound 162 times in high leverage situations and on 144 occasions with base runners. Arizona bullpen pitchers hold an inherited score percentage of 33.5% out of their 191 inherited runners. With 164 save situations, the Diamondbacks have 88 holds and 29 blown saves.

The Arizona Diamondbacks have gotten 124 double plays and hold a fielding percentage of .986 (16th in the majors). The Diamondbacks have recorded 1,404 assists, 79 errors and have a total of 4,200 putouts on the campaign. In 12,600 innings played, the Diamondbacks have earned a defensive efficiency of 69.7% (19th in professional baseball).

So far in his pro baseball career, Gallen has given up 836 hits and he has 1,057 punch outs in 1,002 innings. Gallen (66-51 career win-loss mark) has a 3.56 earned run average while allowing 7.5 hits per 9 innings. He has given up 396 earned runs while earning a WHIP of 1.154 and having a FIP of 3.5. He has a K/BB ratio of 3.29 and he has gone up against 4,118 hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-152)

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