Milwaukee Brewers vs Pittsburgh Pirates Prediction, 9/6/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Pittsburgh Pirates

Date: Saturday, September 6, 2025

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: Milwaukee (-196) Pittsburgh (+162)

PNC Park is where the Pittsburgh Pirates (63-77) will attempt to defeat the Milwaukee Brewers (86-54) on Saturday. The moneyline on this game has the Brewers at -196 and the Pirates are coming in at +162. The over/under has been set at 9. The pitchers taking the mound are Brandon Woodruff and Mitch Keller.

Milwaukee has a slugging rate of .409 and have struck out 1,095 times, while drawing a walk on 484 occasions. They have recorded 667 RBI's in addition to 1,233 hits this season, while their batting average is sitting at .259. The Brewers have recorded 227 two-baggers as a team and have hit 152 baseballs out of the park. They have accumulated 717 runs and have an OBP of .333. As a squad, the Milwaukee Brewers are putting up 5.1 runs per game, which is 2nd in the league.

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They have earned a strikeout to walk ratio of 2.64 and the pitching staff holds a collective WHIP of 1.24. Brewers pitchers have relinquished 148 home runs and 553 runs (4th in baseball). Milwaukee has conceded 1,083 hits (7.8 per 9 innings) and also 505 earned runs. The Brewers have compiled a team earned run average of 3.65 on the campaign (2nd in baseball), and their staff has rung up 1,221 hitters. They have walked 462 opposing players and their FIP is 3.97 as a squad this season.

The Brewers have sent 475 relievers to the hill for the season. The relief pitchers have inherited 187 base runners on the season and 30.5% of them ended up scoring. They have earned 40 saves this season and have blown 19 of 59 save opportunities. The Brewers bullpen have recorded a save rate of 67.8% and have come into the game in 160 save situations. The relievers have a total of 97 holds this year (2nd in baseball). Brewers pitchers have gone to the mound with runners on 125 times in addition to having 164 appearances in high leverage situations.

The Miami Marlins have accounted for 3,740 putouts this season, in addition to 1,119 assists and 64 errors. Their fielding percentage is currently at .987 which has them sitting 10th in MLB, and have 104 double plays. The Brewers have turned 70.8% of baseballs in play into outs out of their 11,220 innings, which ranks them 6th in the majors.

Woodruff (51-28 win-loss record in his career) is the owner of a FIP of 3.09 while going up against 2,946 hitters during his time in the major leagues. He has conceded 576 base knocks (7.1 hits per nine innings) and has 190 walks. His earned run average is 3.14 (256 earned runs allowed) and his career WHIP is 1.045. Woodruff has taken the hill for 733 innings and is sitting with 854 K's during his MLB career.

The Pirates have a team SLG% of .353 and they are earning 3.66 runs per contest (30th in baseball). They have put up 210 two-baggers, while getting a free base 460 times and putting up 512 runs. Pittsburgh is sitting with 102 home runs on the campaign to go along with 492 RBIs. They have struck out on 1,216 occasions (9th in MLB) and have earned a total of 1,086 hits. The Pittsburgh Pirates have an on-base percentage of .308 and a team batting average of .234 this year.

The Pirates have a team WHIP of 1.218 and are the owners of a FIP of 3.90 as a staff this season. They currently have a K/BB ratio of 8.00 (1,104 strikeouts against 404 bases on balls). They are currently ranked 7th in baseball as a pitching staff in total hits allowed with 1,099. They have conceded 134 homers and they yield 4.15 runs per 9 innings (7th in the league). The Pittsburgh pitching staff have yielded 569 runs over the course of the season while having a team ERA of 3.88 (532 earned runs conceded).

Pittsburgh relievers have an inherited score rate of 36.9% out of their 187 inherited runners. Their bullpen pitchers have come in 133 times in high leverage situations and on 120 occasions with base runners. With 119 save situations, the Pirates have recorded 64 holds and also 21 blown saves. They are ranked 23rd in MLB with a save rate of 60.4%, and they have dispatched 434 bullpen pitchers to the mound on the season. Pittsburgh has had relief pitchers step onto the hill in 53 save chances and they have earned 32 saves.

The Pittsburgh Pirates have gotten 101 double plays and have earned a fielding percentage of .986 (13th in MLB). The Pirates have racked up 1,165 assists, 67 errors and are sitting with 3,704 putouts on the season. In 11,112 innings played, the Pirates are sitting with a defensive efficiency of 70.9% (5th in professional baseball).

During his MLB career, Keller has given up 898 base knocks while tallying 819 K's in 857 innings pitched. Keller (42-63 career mark) holds a 4.53 earned run average while conceding 9.4 hits per 9 innings. He has given up a total of 431 ER's while earning a WHIP of 1.388 and having a FIP of 4.5. He has a K/BB ratio of 2.80 and he has gone up against 3,735 batters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (+162)

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