Milwaukee Brewers vs Pittsburgh Pirates Prediction, 9/7/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Pittsburgh Pirates

Date: Sunday, September 7, 2025

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: Milwaukee (-210) Pittsburgh (+172)

The Milwaukee Brewers (86-55) are traveling to PNC Park on Sunday where they will try to beat the Pittsburgh Pirates (64-77). The line on this matchup has Milwaukee at -210 and Pittsburgh is priced at +172. The betting total is set at 8. The expected starting pitchers will be Jacob Misiorowski and Carmen Mlodzinski.

As a team, the Milwaukee Brewers are knocking in 5.1 runs per contest, which ranks them 2nd in MLB. They have notched a total of 717 runs scored while holding a team OBP of .332. The Brewers have accumulated 229 doubles as a team and have hit 152 balls out of the park. They have 667 RBI's as well as 1,240 hits this year, and their team batting average is at .259. Milwaukee is slugging .408 and have been rung up 1,102 times, while drawing a walk on 486 occasions.

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The Brewers have compiled a team ERA of 3.63 on the year (2nd in baseball), and they have rung up 1,234 batters. Brewers pitchers have given up 148 long balls and also 555 runs (4th in MLB). They have walked 466 opposing hitters and their FIP is 3.95 as a team so far this season. Milwaukee has surrendered 1,089 base hits (7.8 per 9 innings) and 507 earned runs. Their strikeout to walk ratio is 2.65 and the pitching staff has earned a collective WHIP of 1.24.

Brewers pitchers have entered the game with runners on base 126 times as well as having 165 appearances in high leverage situations. The bullpen have a total of 97 holds this year (2nd in MLB). The Brewers bullpen have earned a save rate of 67.8% and have entered the game in 160 save situations. They have earned 40 saves this season and have missed out on 19 of their 59 chances to save the game. The relief pitchers have inherited 188 base runners on the campaign with 30.3% of those runners ended up scoring. The Brewers have sent 479 relief pitchers to the mound this season.

The Brewers have turned 70.8% of baseballs in play into outs out of their 11,301 innings on the field, which has them sitting 6th in MLB. The Miami Marlins have earned a total of 3,767 putouts at this point in the season, as well as 1,127 assists and 64 errors. Their fielding rate is at .987 which puts them in 10th in MLB, and have a total of 104 double plays.

Misiorowski has taken the hill for 48 innings and has 69 K's so far in his pro baseball career. His ERA is 4.50 (24 ER's allowed) and he has a career WHIP of 1.146. He has conceded 33 hits (6.2 hits per 9 innings) and has 22 walks. Misiorowski (4-2 career win-loss record) has a FIP of 4.43 while he has gone up against 195 hitters in the major leagues.

The Pittsburgh Pirates have tallied a team OBP of .308 in addition to a team batting average of .234 over the course of the season. They have struck out on 1,227 occasions (8th in the league) and have 1,095 base knocks. Pittsburgh has compiled 102 home runs on the season as well as 497 RBIs. The Pirates have a team slugging % of .353 and they tally 3.67 runs per game (30th in the league). They have tallied 211 doubles, while taking a walk 463 times and earning 517 runs.

The Pirates have a team WHIP of 1.216 in addition to having a FIP of 3.89 as a unit on the campaign. Their K/BB ratio sits at 8.10 (1,116 strikeouts against 405 free passes). They are sitting at 7th in MLB as a staff in total hits conceded with 1,107. They have given up 135 dingers and they yield 4.14 runs per 9 innings (6th in MLB). The Pittsburgh pitching staff have allowed 572 runs so far this year while having an ERA of 3.87 (535 earned runs conceded).

Pittsburgh has had relief pitchers enter the game in 54 save opportunities and they have walked away with 33 saves. They are currently ranked 21st in MLB holding a save rate of 61.1%, and they have sent 438 relievers onto the diamond so far this season. Their relief pitchers have stepped onto the mound 134 times in high leverage situations and also on 121 occasions with runners on. Pittsburgh bullpen pitchers have an inherited score percentage of 37.0% out of 189 inherited runners. Sitting with 120 save situations, the Pirates have 64 holds and 21 blown saves.

The Pittsburgh Pirates have turned 101 double plays and have accounted for a fielding rate of .987 (14th in pro baseball). The Pirates have racked up 1,171 assists, 67 errors and have accounted for 3,731 putouts on the season. In their 11,193 innings played, the Pirates hold a defensive efficiency of 70.9% (5th in pro baseball).

During his MLB career, Mlodzinski has surrendered 159 base knocks while totaling 155 K's in 172 innings pitched. Mlodzinski (11-15 mark in his career) holds a 3.40 ERA while giving up 8.3 hits per nine innings. He has allowed a total of 65 earned runs while holding a WHIP of 1.278 and having a FIP of 3.3. His K/BB ratio is 2.54 and he has gone up against 729 hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (+172)

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