Milwaukee Brewers vs San Diego Padres Prediction, 9/24/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs San Diego Padres

Date: Wednesday, September 24, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Milwaukee (-145) San Diego (+125)

The Milwaukee Brewers (95-62) are hitting the road to Petco Park on Wednesday where they will take on the San Diego Padres (86-71). The line on this matchup has Milwaukee at -145 while San Diego is priced at +125. The total comes in at 8.5. The expected starting pitchers will be Quinn Priester and Dylan Cease.

Milwaukee is slugging .406 and have struck out 1,224 times, while taking a walk on 547 occasions. They have tallied 738 RBI's and 1,392 base knocks on the season, while their team batting average is .260. The Brewers have hit 256 two-baggers as a unit and have hit 163 baseballs out of the stadium. They have racked up 794 runs and have an on-base percentage of .334. As a unit, the Milwaukee Brewers are putting up 5.1 runs per game, which ranks them 3rd in MLB.

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Their strikeout to walk ratio sits at 2.68 and the pitching staff has a collective WHIP of 1.23. Brewers pitchers have relinquished 161 home runs and 614 runs in total (3rd in baseball). Milwaukee has allowed 1,199 base hits (7.7 per 9 innings) as well as 561 earned runs. The Brewers hold a team ERA of 3.61 for the year (2nd in the league), and the staff has struck out 1,388 hitters. They have walked 518 opposing players and their FIP sits at 3.91 as a team on the year.

Brewers pitchers have stepped onto the hill with runners on 142 times in addition to having 182 appearances in high leverage situations. The relief pitchers have earned 102 holds on the campaign (6th in baseball). The Brewers relief pitchers have a save rate of 67.2% and have stepped onto the mound in 170 save situations. They have recorded 43 saves so far this year and have not converted 21 out of their 64 chances to get a save. The relievers have inherited 212 base runners on the season and 30.7% of them ended up scoring. The Brewers have dispatched 532 relief pitchers to the hill on the campaign.

The Brewers have converted 70.9% of balls hit into play into outs in their 12,582 innings, which has them sitting at 5th in the majors. The Miami Marlins have notched a total of 4,194 putouts thus far, in addition to 1,257 assists and 72 errors. Their fielding rate is holding at .987 which has them sitting 9th in baseball, and have a total of 117 double plays.

Priester (19-11 career record) has earned a FIP of 4.37 and he has faced 1,085 hitters during his time in the majors. He has conceded 250 hits (9.0 hits per 9 innings) and has had 90 walks. His ERA is 4.44 (124 earned runs allowed) and he has a WHIP of 1.353. Priester has thrown 251 innings and has tallied 197 K's so far in his MLB career.

San Diego has accounted for 143 long balls this year and 631 runs batted in. They have hit 248 two-baggers, while walking 494 times and scoring 670 runs. The San Diego Padres have earned an OBP of .321 and a batting average of .252 on the year. The Padres have a slugging percentage of .388 and they are earning 4.27 runs per contest (19th in the league). They have struck out on 1,123 occasions (28th in baseball) and have tallied 1,325 base knocks.

The Padres hold a team WHIP of 1.205 in addition to having a FIP of 4.03 as a staff over the course of the season. They have earned a strikeout to walk ratio of 8.90 (1,378 strikeouts against 514 walks). They have a ranking of 1st in MLB as a staff in total hits surrendered with 1,159. They have allowed 173 homers and they allow 3.95 runs per 9 innings (2nd in MLB). The San Diego pitching staff have given up 609 runs so far this year and come in with a team ERA of 3.67 (566 earned runs surrendered).

San Diego relief pitchers hold an inherited score percentage of 29.4% of 255 inherited base runners. Their relief pitchers have stepped onto the mound 207 times in high leverage situations and on 181 occasions with runners on base. With 172 save situations, the Padres have 103 holds and also 16 blown saves. They rank 1st in baseball with a save percentage of 75.0%, and they have dispatched 558 relievers onto the field over the course of the season. San Diego has called on relievers to step onto the mound in 64 save chances and they have recorded 48 saves.

In their 12,492 innings played, the Padres are sitting with a defensive efficiency of 71.8% (2nd in professional baseball). The San Diego Padres have gotten 112 double plays and own a fielding percentage of .987 (10th in baseball). The Padres have recorded 1,189 assists, 71 errors and have accounted for 4,164 putouts during this campaign.

Cease (65-58 career mark) has earned a 3.89 earned run average while conceding 7.6 hits per nine innings. His K/BB ratio is 2.86 and he has faced 4,281 hitters so far in his career. He has given up a total of 437 ER's while holding a WHIP of 1.263 and having a FIP of 3.8. So far in his pro baseball career, Cease has conceded 848 base knocks while accumulating 1,223 strikeouts in 1,010 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Milwaukee (-145)

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