Milwaukee Brewers vs San Francisco Giants Prediction, 4/22/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs San Francisco Giants

Date: Tuesday, April 22, 2025

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Milwaukee (+162) San Francisco (-196)

The Milwaukee Brewers (12-10) are headed to Oracle Park on Tuesday where they will attempt to beat the San Francisco Giants (14-8). The moneyline on this contest has the Brewers at +162 while the Giants are sitting at -196. The total has been set at 9. The starting pitchers are Jose Quintana and Jordan Hicks.

Milwaukee is slugging .379 and have struck out 179 times, while taking a walk on 71 occasions. They have accrued 98 runs batted in and 176 base knocks for the season, and their average at the plate is at .240. The Brewers have accounted for 28 two-baggers as a team and have knocked 22 balls out of the park. They have accumulated 112 runs and hold an OBP of .312. As a squad, the Milwaukee Brewers are scoring 5.1 runs per outing, which ranks them 5th in baseball.

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The Brewers have compiled a team ERA of 4.16 so far this year (19th in baseball), and the staff has rung up 190 batters. Brewers pitchers have conceded 30 home runs in addition to 101 runs in total (19th in the league). They have walked 83 opposing batters and their FIP is 4.50 as a team for the season. Milwaukee has allowed 167 base knocks (7.7 per 9 innings) and 90 earned runs. They have earned a K/BB ratio of 2.29 and their pitching staff has earned a collective WHIP of 1.29.

Brewers pitchers have entered the contest with players on base 18 times in addition to having 16 appearances in high leverage situations. The bullpen have a total of 15 holds over the course of the season (14th in baseball). The Brewers bullpen have a save rate of 66.7% and have stepped onto the mound in 22 save situations. They have recorded 4 saves over the course of the season and have not converted 2 out of their 6 save opportunities. The bullpen pitchers have inherited 26 base runners so far this year and 46.2% of them earned a run for their team. The Brewers have dispatched 76 relievers to the mound this season.

The Miami Marlins have earned 584 putouts thus far, as well as 148 assists and 12 errors. Their fielding percentage is at .984 which has them ranked 20th in pro baseball, and have a total of 15 double plays. The Brewers have turned 72.1% of balls hit into play into outs out of 1,752 innings, which has them ranked 8th in baseball.

Quintana has thrown 1,981 innings and has 1,733 K's during his career. His earned run average is 3.72 (820 earned runs allowed) and his career WHIP is 1.274. He has given up 1,931 hits (8.8 hits per 9 innings) with 594 walks. Quintana (104-103 career mark) sits with a FIP of 3.67 while he has gone up against 8,302 hitters during his time in the major leagues.

San Francisco has hit 25 HRs on the campaign to go along with 106 runs batted in. They have tallied 44 doubles, while getting a free base 84 times and recording 111 runs. The San Francisco Giants have a team OBP of .305 and a batting average of .224 this season. The Giants have a slugging percentage of .395 and they average 5.05 runs per contest (6th in MLB). They have been rung up on 206 occasions (6th in MLB) and are sitting with 166 hits.

The Giants have a WHIP of 1.224 in addition to having a FIP of 3.58 as a squad for the year. Their K/BB ratio comes in at 9.40 (199 strikeouts against 77 bases on balls). They are sitting at 8th in MLB as a pitching staff in total hits relinquished with 157. They have given up 19 long balls and they relinquish 3.81 runs per 9 innings (6th in baseball). The San Francisco pitching staff have surrendered 81 runs on the year while having a team ERA of 3.53 (75 earned runs surrendered).

San Francisco has had relief pitchers step onto the mound in 11 save chances and they have earned 7 saves. They rank 17th in the league with a save rate of 63.6%, and they have dispatched 69 relievers to the mound on the season. Their relievers have come in 25 times in high leverage situations and on 13 occasions with base runners. San Francisco relievers hold an inherited score percentage of 37.5% out of their 24 inherited base runners. With 28 save situations, the Giants have tallied 17 holds and 4 blown saves.

In their 1,722 innings played, the Giants have earned a defensive efficiency of 71.2% (13th in baseball). The San Francisco Giants have turned 18 double plays and have earned a fielding percentage of .991 (1st in the majors). The Giants have racked up 196 assists, 7 errors and have notched a total of 574 putouts on the season.

In his pro baseball career, Hicks has allowed 316 hits while totaling 370 K's in 375 frames. He has surrendered a total of 169 earned runs while holding a WHIP of 1.349 and being the owner of a FIP of 4.0. He has a strikeout to walk ratio of 1.95 and he has faced 1,620 opposing hitters so far in his MLB career. Hicks (16-30 career win-loss record) has a 4.05 ERA and has conceded 7.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Milwaukee (+162)

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