Milwaukee Brewers vs St. Louis Cardinals Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs St. Louis Cardinals

Date: Friday, September 19, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Milwaukee (-196) St. Louis (+162)

Busch Stadium is the location where the St. Louis Cardinals (74-79) will go up against the Milwaukee Brewers (93-59) on Friday. The moneyline on this game has Milwaukee at -196 while St. Louis is coming in at +162. The over/under comes in at 9. The pitchers who are expected to start are Jacob Misiorowski and Sonny Gray.

The Brewers have tallied 248 two-baggers as a squad and have knocked 162 baseballs out of the park. Milwaukee is slugging .409 and have been rung up 1,185 times, while being walked on 528 occasions. As a unit, the Milwaukee Brewers are notching 5.1 runs per outing, which has them at 2nd in the league. They have 724 RBI's and 1,348 hits for the year, while their batting average comes in at .261. They have earned a total of 780 runs scored while holding a team on-base percentage of .334.

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Their strikeout to walk ratio is 2.69 and their pitching staff has a collective WHIP of 1.23. Brewers pitchers have surrendered 158 home runs and also 593 runs in total (3rd in baseball). Milwaukee has allowed 1,157 hits (7.7 per 9 innings) and also 542 earned runs. The Brewers have a team earned run average of 3.61 for the year (2nd in baseball), and they have struck out 1,345 hitters. Their pitching staff has walked 500 opposing hitters and their FIP comes in at 3.92 as a unit on the campaign.

Brewers pitchers have entered the game with opponents on base 133 times as well as having 170 appearances in high leverage situations. The relief pitchers have a total of 100 holds on the year (5th in the league). The Brewers bullpen have a save percentage of 68.9% and have stepped onto the mound in 165 save situations. They have 42 saves over the course of the season and have blown 19 of their 61 chances to get a save. The bullpen pitchers have inherited 197 runners over the course of the season and 30.5% of them ended up scoring. The Brewers have dispatched 513 relievers to the mound this year.

The Brewers have turned 71.0% of balls in play into outs in their 12,174 innings on the diamond, which has them sitting 4th in professional baseball. The Miami Marlins are sitting with 4,058 putouts this season, as well as 1,207 assists and 69 errors. Their fielding percentage sits at .987 which has them sitting 10th in MLB, and they have turned 111 double plays.

Misiorowski has thrown 60 innings and has accounted for 81 K's so far in his MLB career. His ERA is 4.35 (29 earned runs allowed) and he has a WHIP of 1.133. He has allowed 43 base hits (6.5 hits per 9 innings) with 25 walks. Misiorowski (5-2 win-loss record in his career) has earned a FIP of 4.28 while facing 243 batters during his time in the major leagues.

The St. Louis Cardinals have recorded an on-base percentage of .314 as well as a team batting average of .244 for the year. They have struck out on 1,240 occasions (21st in the league) and have accounted for 1,255 base knocks. St. Louis is sitting with 142 home runs so far this year and 620 RBIs. The Cardinals have a slugging percentage of .378 and they are recording 4.27 runs per contest (21st in MLB). They have 243 doubles, while getting a free base 451 times and scoring 653 runs.

The St. Louis pitching staff have allowed 711 runs on the season while holding a team ERA of 4.29 (645 earned runs conceded). They have given up 156 long balls and they allow 4.73 runs per 9 innings (22nd in MLB). The Cardinals hold a team WHIP of 1.320 and have a FIP of 4.04 as a squad so far this year. They currently have a strikeout to walk ratio of 7.50 (1,135 strikeouts vs 438 free passes). They rank 26th in the league as a pitching staff in total hits allowed with 1,349.

Sitting with 152 save situations, the Cardinals have amassed 86 holds and also 22 blown saves. St. Louis has had relief pitchers take the mound in 62 save chances and they have come away with 40 saves. Their bullpen pitchers have stepped onto the mound 148 times in high leverage situations and on 148 occasions with runners on. St. Louis bullpen pitchers hold an inherited score percentage of 33.0% of 206 inherited runners. They rank 12th in the league with a save rate of 64.5%, and they have dispatched 456 relievers onto the diamond on the campaign.

The St. Louis Cardinals have turned 121 double plays and have a fielding percentage of .987 (13th in MLB). The Cardinals have recorded 1,465 assists, 75 errors and have a tally of 4,062 putouts on the season. Out of their 12,186 innings on the field, the Cardinals have a efficiency on defense of 69.0% (22nd in baseball).

During his career, Gray has given up 1,659 base knocks while he has tallied 1,911 strikeouts in 1,905 innings pitched. He has conceded a total of 760 earned runs while earning a WHIP of 1.196 and being the owner of a FIP of 3.5. He has a K/BB ratio of 3.09 and he has gone up against 7,897 batters during his career. Gray (124-102 record in his career) holds a 3.59 earned run average while allowing 7.8 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+162)

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