Minnesota Twins vs Chicago White Sox Prediction, 8/22/2025 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Chicago White Sox

Date: Friday, August 22, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Minnesota (-160) Chicago (+132)

The Chicago White Sox (45-82) will try to defeat the Minnesota Twins (58-68) at Rate Field on Friday. The moneyline on this contest has the Twins at -160 and the White Sox are coming in at +132. The over/under has been set at 8.5. The starting pitchers will be Zebby Matthews and Aaron Civale.

As a squad, the Minnesota Twins are notching 4.2 runs per game, which is 22nd in the league. They have accumulated 517 runs and have an on-base percentage of .309. The Twins have hit 192 two-baggers as a team and have hit 144 balls out of the stadium. They have recorded 493 runs batted in in addition to 986 base knocks on the year, and their average at the plate is at .238. Minnesota is slugging .396 and have been called out on strikes 1,028 times, while drawing a walk on 369 occasions.

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They have a K/BB ratio of 3.10 and their pitching staff has recorded a WHIP of 1.28. Twins pitchers have yielded 143 long balls and 554 runs (18th in MLB). Minnesota has yielded 1,062 base hits (8.8 per 9 innings) as well as 515 earned runs. The Twins have an ERA of 4.24 over the course of the season (20th in the league), and their staff has struck out 1,045 hitters. They have walked 337 hitters and their FIP is 3.98 as a team on the year.

The Twins have dispatched 427 relievers to the mound on the campaign. The relief pitchers have inherited 133 base runners on the season and 34.6% of them crossed home plate. They have 23 saves on the season and have not converted 18 of their 41 save chances. The Twins bullpen have earned a save percentage of 56.1% and have come into the game in 121 save situations. The relief pitchers have tallied 78 holds this year (9th in the league). Twins relief pitchers have entered the game with runners on 93 times in addition to having 146 appearances in high leverage situations.

The Twins have converted 68.9% of baseballs in play into outs out of their 9,828 innings, which ranks them 25th in the majors. The Milwaukee Brewers are sitting with 3,276 putouts for the season, as well as 918 assists and 57 errors. Their fielding percentage is at .987 which puts them in 16th in the majors, and have a total of 69 double plays.

Matthews has taken the hill for 85 innings and has racked up 106 K's in his career. His ERA is 5.81 (55 earned runs allowed) and he has a WHIP of 1.538. He has conceded 105 hits (11.1 hits per nine innings) and has 26 free passes. Matthews (4-8 career record) is the owner of a FIP of 5.72 while facing 388 hitters during his time in the majors.

Chicago has recorded 124 home runs this year as well as 463 RBIs. They have tallied 190 doubles, while getting a free base 399 times and scoring 480 runs. The Chicago White Sox have earned an on-base percentage of .301 and a team batting average of .231 so far this year. The White Sox hold a team slugging percentage of .371 and they are recording 3.84 runs per game (27th in MLB). They have been rung up on 1,047 occasions (15th in the league) and have a total of 954 hits.

The Chicago pitching staff have conceded 560 runs on the year while holding a team ERA of 4.17 (505 earned runs conceded). They have allowed 138 dingers and they relinquish 4.62 runs per 9 innings (22nd in baseball). The White Sox have a team WHIP of 1.367 with a FIP of 4.45 as a unit this year. Their strikeout to walk ratio is 7.90 (955 strikeouts vs 458 bases on balls). They are sitting at 18th in MLB as a pitching staff in total hits allowed with 1,032.

Chicago bullpen pitchers have an inherited score rate of 29.6% of 169 inherited runners. Their relief pitchers have taken the field 109 times in high leverage situations and also on 118 occasions with runners on. With 87 save situations, the White Sox have accrued 52 holds in addition to 18 blown saves. They rank 30th in the league with a save rate of 48.6%, and they have dispatched 396 relievers to the hill this year. Chicago has had relief pitchers enter the game in 35 save opportunities and they have tallied 17 saves.

In 9,813 innings on the diamond, the White Sox have a defensive efficiency of 69.7% (17th in the majors). The Chicago White Sox have turned 102 double plays and have a fielding rate of .982 (27th in professional baseball). The White Sox have recorded 1,018 assists, 78 errors and have amassed 3,271 putouts this season.

So far in his career, Civale has conceded 673 hits while he has tallied 642 punch outs in 715 innings. Civale (42-43 record in his career) has earned a 4.13 earned run average while conceding 8.5 hits per 9 innings. He has given up a total of 328 earned runs while earning a WHIP of 1.218 and having a FIP of 4.1. He has a K/BB ratio of 3.24 and he has faced 2,978 opposing hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+132)

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