New York Yankees vs Minnesota Twins Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Minnesota Twins

Date: Tuesday, September 16, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: New York (-150) Minnesota (+125)

Target Field is the location where the Minnesota Twins (65-84) will attempt to defeat the New York Yankees (83-66) on Tuesday. The line on this matchup has the Yankees at -150 while the Twins are sitting at +125. The betting total is set at 8.5. The pitchers expected to start will be Cam Schlittler and Zebby Matthews.

As a team, the New York Yankees are recording 5.2 runs/g, which ranks them 1st in the league. They are sitting with 774 runs and hold an OBP of .329. The Yankees have tallied 235 doubles as a unit and have hit 254 baseballs out of the stadium. They have amassed 747 runs batted in and 1,257 base knocks so far this season, while their team batting average is at .249. New York is slugging .454 and have struck out 1,333 times, while drawing a walk on 578 occasions.

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The Yankees have an ERA of 4.00 so far this year (16th in baseball), and the staff has rung up 1,320 batters. Yankees pitchers have yielded 162 long balls and 645 total runs (16th in baseball). They have walked 518 opposing batters and their FIP sits at 4.04 as a team so far this year. New York has allowed 1,160 hits (7.9 per 9 innings) in addition to 588 earned runs. They have a strikeout to walk ratio of 2.55 and their pitching staff sits with a WHIP of 1.27.

Yankees pitchers have come into the game with players on base 156 times as well as having 152 appearances in high leverage situations. The relief pitchers have earned 92 holds this year (8th in the league). The Yankees relievers have recorded a save percentage of 65.6% and have entered the game in 154 save situations. They have recorded 40 saves over the course of the season and have blown 21 of their 61 chances to get a save. The relief pitchers have inherited 239 base runners this season with 28.0% of them ended up scoring. The Yankees have sent 490 relief pitchers to the hill this season.

The Yankees have converted 70.4% of balls hit into play into outs out of their 11,913 innings, which has them ranked 10th in MLB. The New York Mets have a tally of 3,971 putouts this season, in addition to 1,289 assists and 87 errors. Their fielding rate is at .984 which is 25th in the majors, and they have turned 99 double plays.

Schlittler has thrown 56 frames and has totaled 63 punch outs in his MLB career. Schlittler (3-3 career win-loss record) sits with a FIP of 3.01 while he has faced 236 hitters during his time in the majors. His earned run average is 3.05 (19 ER's allowed) and his career WHIP is 1.321. He has given up 50 hits (8.0 hits per 9 innings) with 24 walks.

The Twins hold a slugging percentage of .399 and they score 4.24 runs per game (24th in baseball). They have 227 doubles, while getting a free base 463 times as well as putting up 632 runs. Minnesota has accumulated 178 home runs this season to go along with 600 RBIs. They have been rung up on 1,239 instances (16th in the league) and are sitting with 1,199 base knocks. The Minnesota Twins have earned an OBP of .313 as well as a team batting average of .239 this year.

The Twins are sitting with a team WHIP of 1.332 and have a FIP of 4.15 as a staff over the course of the season. They currently have a strikeout to walk ratio of 8.60 (1,252 strikeouts vs 426 bases on balls). They rank 25th in the league as a pitching staff in total hits conceded with 1,320. They have allowed 180 homers and they concede 4.95 runs per 9 innings (24th in MLB). The Minnesota pitching staff have allowed 721 runs so far this season while holding an ERA of 4.61 (672 earned runs yielded).

Minnesota bullpen pitchers hold an inherited score percentage of 35.8% of 162 inherited runners. Their bullpen pitchers have taken the field 165 times in high leverage situations and on 112 occasions with base runners. With 142 save situations, the Twins have earned 89 holds and also 24 blown saves. They sit at 28th in baseball with a save rate of 52.9%, and they have sent 503 relievers onto the field on the campaign. Minnesota has had bullpen pitchers take the mound in 51 save chances and they have come away with 27 saves.

In their 11,799 innings on the diamond, the Twins have earned a efficiency on defense of 68.1% (29th in pro baseball). The Minnesota Twins have gotten 90 double plays and have notched a fielding percentage of .985 (18th in MLB). The Twins have recorded 1,119 assists, 77 errors and have 3,933 putouts for the season.

So far in his pro baseball career, Matthews has allowed 130 base hits while totaling 123 punch outs in 106 innings. Matthews (5-9 career mark) has a 5.67 earned run average and has conceded 11.0 hits per nine innings. He has given up a total of 67 earned runs while earning a WHIP of 1.533 and being the owner of a FIP of 5.6. He has a strikeout to walk ratio of 3.73 and he has faced 482 opposing hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Minnesota (+125)

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