New York Yankees vs St. Louis Cardinals Prediction, 8/17/2025 MLB Picks, Best Bets & Odds

Game: New York Yankees vs St. Louis Cardinals

Date: Sunday, August 17, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: New York (-130) St. Louis (+110)

Busch Stadium is the site where the St. Louis Cardinals (61-61) will try to defeat the New York Yankees (64-57) on Sunday. The odds on this game have the Yankees at -130 and the Cardinals are sitting at +110. The total has been set at 9. The starting pitchers are Will Warren and Miles Mikolas.

New York has a slugging rate of .446 and have been called out on strikes 1,051 times, while being walked on 460 occasions. They have 587 RBI's in addition to 1,019 base knocks for the year, while their average at the plate is .249. The Yankees have accrued 196 doubles as a squad and have hit 191 baseballs out of the stadium. They have accumulated 612 runs while holding a team OBP of .328. As a squad, the New York Yankees are recording 5.1 runs per game, which is 3rd in the league.

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They have earned a strikeout to walk ratio of 2.56 and their pitching staff holds a collective WHIP of 1.25. Yankees pitchers have conceded 136 home runs and 522 runs in total (17th in the league). New York has conceded 923 hits (7.8 per 9 innings) as well as 478 earned runs. The Yankees have a team earned run average of 4.01 for the year (16th in the league), and the staff has rung up 1,076 batters. Their pitching staff has walked 420 opposing players and their FIP comes in at 4.04 as a squad for the season.

The Yankees have sent 403 relievers to the hill this season. The relief pitchers have inherited 194 runners this season with 26.8% of them ended up crossing the plate. They have 31 saves so far this year and have blown 17 of their 48 save opportunities. The Yankees relief pitchers have a save percentage of 64.6% and stepped onto the hill in 120 save situations. The relief pitchers have tallied 71 holds on the year (12th in MLB). Yankees relief pitchers have entered the game with runners on 131 times and also have had 121 appearances in high leverage situations.

The Yankees have transformed 71.0% of balls hit into play into outs in their 9,645 innings, which has them ranked 8th in MLB. The New York Mets have a total of 3,215 putouts this season, in addition to 1,026 assists and 66 errors. Their fielding rate is holding at .985 which is 22nd in the majors, and they have turned 76 double plays.

Warren has taken the ball for 144 innings and has earned 169 K's so far in his pro baseball career. Warren (7-8 career mark) has earned a FIP of 5.22 and he has gone up against 642 hitters in the majors. His earned run average is 5.30 (85 ER's allowed) and he has a WHIP of 1.455. He has given up 146 base knocks (9.1 hits per 9 innings) and has had 64 walks.

The Cardinals hold a team slugging % of .386 and they average 4.31 runs per game (18th in baseball). They have recorded 208 doubles, while taking a walk 371 times as well as scoring 526 runs. St. Louis has 115 home runs this season as well as 502 RBIs. They have been called out on strikes on 945 occasions (25th in the league) and have earned a total of 1,022 hits. The St. Louis Cardinals have accumulated an on-base percentage of .318 in addition to a team batting average of .249 for the year.

The Cardinals are sitting with a team WHIP of 1.280 and are the owners of a FIP of 3.88 as a pitching staff so far this season. They sit at 24th in MLB as a pitching staff in total hits relinquished with 1,065. The St. Louis pitching staff have allowed 547 runs on the season while having an ERA of 4.19 (501 earned runs relinquished). Their strikeout to walk ratio is 7.30 (880 strikeouts vs 314 walks). They have relinquished 119 home runs and they concede 4.57 runs per 9 innings (23rd in baseball).

St. Louis has had bullpen pitchers step onto the hill in 46 save opportunities and they have walked away with 30 saves. They are ranked 9th in the league holding a save rate of 65.2%, and they have dispatched 360 relievers onto the diamond over the course of the season. Their relievers have stepped onto the hill 115 times in high leverage situations and on 115 occasions with base runners. St. Louis relievers hold an inherited score percentage of 32.5% out of their 157 inherited base runners. Sitting with 116 save situations, the Cardinals have earned 67 holds and 16 blown saves.

Out of their 9,699 innings on the diamond, the Cardinals are sitting with a efficiency on defense of 69.4% (20th in MLB). The St. Louis Cardinals have gotten 91 double plays and have earned a fielding percentage of .987 (8th in baseball). The Cardinals have accrued 1,175 assists, 56 errors and have accumulated 3,233 putouts for the year.

Thus far in his career, Mikolas has conceded 1,234 hits and he has 874 strikeouts in 1,213 innings pitched. Mikolas (70-73 career win-loss record) has a 4.24 ERA and has conceded 9.2 hits per nine innings. He has allowed a total of 571 earned runs while earning a WHIP of 1.210 and having a FIP of 4.2. His strikeout to walk ratio is 3.74 and he has faced 5,050 opposing batters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take St. Louis (+110) and under 9 runs

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