Pittsburgh Pirates vs Cincinnati Reds Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Cincinnati Reds

Date: Tuesday, September 23, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Pittsburgh (+126) Cincinnati (-152)

The Pittsburgh Pirates (67-89) are headed to Great American Ball Park on Tuesday where they will attempt to defeat the Cincinnati Reds (80-76). The moneyline on this game has the Pirates at +126 while the Reds are opening at -152. The over/under has been set at 8.5. The starting pitchers will be Johan Oviedo and Brady Singer.

The Pirates have tallied 228 doubles as a unit and have smacked 110 baseballs out of the park. Pittsburgh has a slugging % of .347 and have been called out on strikes 1,356 times, while being walked on 511 occasions. As a unit, the Pittsburgh Pirates are scoring 3.6 runs per game, which has them at 30th in the league. They have earned 529 runs batted in as well as 1,180 base knocks over the course of the season, and their team batting average is sitting at .230. They have earned a total of 550 runs while holding a team OBP of .304.

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The Pirates have a team earned run average of 3.85 so far this season (10th in the league), and the staff has struck out 1,245 hitters. Pirates pitchers have yielded 147 home runs and also 630 runs in total (8th in baseball). They have walked 456 opposing hitters and their FIP sits at 3.88 as a unit for the season. Pittsburgh has allowed 1,215 base knocks (8.0 per 9 innings) in addition to 585 earned runs. They have accrued a K/BB ratio of 2.73 and the pitching staff sits with a WHIP of 1.22.

The Pirates have dispatched 485 relief pitchers to the mound on the campaign. The bullpen pitchers have inherited 211 base runners for the year with 36.5% of them crossed home plate. They have 34 saves so far this season and have missed out on 24 out of their 58 save chances. The Pirates relievers have earned a save percentage of 58.6% and stepped onto the hill in 127 save situations. The relief pitchers have earned 67 holds so far this season (26th in the league). Pirates pitchers have gone to the mound with opponents on base 137 times in addition to having 149 appearances in high leverage situations.

The Pirates have turned 70.7% of balls hit into play into outs out of their 12,309 innings on the field, which has them sitting at 7th in pro baseball. The Pittsburgh Pirates have notched a total of 4,103 putouts this season, in addition to 1,278 assists and 75 errors. Their fielding percentage is holding at .986 which has them ranked 14th in pro baseball, and they have turned 112 double plays.

Oviedo has thrown 350 innings and has accounted for 311 strikeouts during his MLB career. His ERA is 4.26 (166 earned runs allowed) and his WHIP is 1.387. He has allowed 316 base hits (8.1 hits per nine innings) and has 170 free passes. Oviedo (15-25 career win-loss record) has a FIP of 4.20 while facing 1,555 hitters in the major leagues.

The Reds hold a team slugging % of .393 and they tally 4.49 runs per contest (13th in baseball). They have 241 doubles, while taking a walk 508 times as well as racking up 696 runs. Cincinnati has hit 161 home runs on the year to go along with 658 runs batted in. They have been called out on strikes on 1,348 instances (9th in MLB) and have 1,279 base hits. The Cincinnati Reds are sitting with a team on-base percentage of .316 in addition to a team batting average of .245 so far this season.

The Reds hold a team WHIP of 1.234 in addition to having a FIP of 4.17 as a squad so far this season. They come in at 9th in baseball as a staff in total hits allowed with 1,218. The Cincinnati pitching staff have given up 663 runs so far this season while having a team ERA of 3.94 (600 earned runs conceded). Their strikeout to walk ratio sits at 8.60 (1,313 strikeouts against 474 walks). They have allowed 187 homers and they surrender 4.35 runs per 9 innings (16th in the league).

Cincinnati has called on relievers to step onto the mound in 59 save chances and they have come away with 37 saves. They rank 18th in baseball with a save rate of 62.7%, and they have sent 525 relievers to the mound this season. Their relief pitchers have stepped onto the mound 162 times in high leverage situations and also on 141 occasions with runners on base. Cincinnati bullpen pitchers have an inherited score percentage of 32.7% out of their 211 inherited base runners. With 159 save situations, the Reds have earned 97 holds and 22 blown saves.

In 12,339 innings played, the Reds have earned a efficiency on defense of 71.0% (4th in MLB). The Cincinnati Reds have turned 97 double plays and hold a fielding percentage of .984 (22nd in pro baseball). The Reds have racked up 1,192 assists, 85 errors and have a total of 4,113 putouts over the course of the season.

In his pro baseball career, Singer has given up 833 base hits and he has 800 strikeouts in 846 innings pitched. He has surrendered a total of 395 earned runs while earning a WHIP of 1.307 and being the owner of a FIP of 4.1. He has a K/BB ratio of 2.93 and he has faced 3,609 batters during his pro baseball career. Singer (50-54 career win-loss record) has a 4.20 ERA while conceding 8.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (-152)

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