Pittsburgh Pirates vs Cincinnati Reds Prediction, 9/24/2025 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Cincinnati Reds

Date: Wednesday, September 24, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Pittsburgh (+132) Cincinnati (-160)

The Pittsburgh Pirates (67-89) are hitting the road to Great American Ball Park on Wednesday where they will try to defeat the Cincinnati Reds (80-76). The odds on this game have the Pirates at +132 while the Reds are coming in at -160. The betting total comes in at 8. The starting pitchers will be Paul Skenes and Hunter Greene.

As a team, the Pittsburgh Pirates are earning 3.6 runs per outing, which is 30th in baseball. They have notched a total of 561 runs while holding a team OBP of .305. The Pirates have accounted for 233 doubles as a team and have knocked 112 baseballs out of the stadium. They have accumulated 540 RBI's as well as 1,195 hits so far this year, and their average at the plate sits at .231. Pittsburgh is slugging .350 and have been called out on strikes 1,364 times, while being walked on 515 occasions.

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The Pirates have a team earned run average of 3.82 for the season (8th in MLB), and their staff has struck out 1,254 batters. Pirates pitchers have relinquished 147 home runs and 630 total runs (7th in MLB). Their pitching staff has walked 456 opposing batters and their FIP sits at 3.86 as a unit so far this season. Pittsburgh has conceded 1,223 base knocks (8.0 per 9 innings) and 585 earned runs. They have earned a K/BB ratio of 2.75 and the pitching staff has earned a collective WHIP of 1.22.

The Pirates have sent 488 relievers to the mound on the season. The bullpen pitchers have inherited 211 base runners on the year with 36.5% of those players ended up crossing the plate. They have accumulated 34 saves on the campaign and have blown 24 of their 58 save chances. The Pirates bullpen have a save rate of 58.6% and have entered the game in 127 save situations. The bullpen have accumulated 67 holds for the season (27th in the league). Pirates pitchers have entered the game with runners on base 137 times as well as having 149 appearances in high leverage situations.

The Pittsburgh Pirates have a total of 4,130 putouts thus far, in addition to 1,288 assists and 75 errors. Their fielding percentage is at .986 which has them sitting 14th in baseball, and have a total of 112 double plays. The Pirates have turned 70.7% of balls hit into play into outs out of their 12,390 innings on the field, which has them ranked 8th in the majors.

Skenes has pitched in 314 frames and has earned 379 K's in his career. His earned run average is 2.01 (70 ER's allowed) and his WHIP is 0.955. He has surrendered 226 hits (6.5 hits per 9 innings) and has 74 free passes. Skenes (21-13 career win-loss record) holds a FIP of 1.98 while he has gone up against 1,225 hitters in the majors.

The Reds have a team SLG% of .392 and they have an average of 4.47 runs per contest (14th in the league). They have 243 two-baggers, while walking 508 times and putting up 697 runs. Cincinnati has recorded 161 long balls so far this year to go along with 659 runs batted in. They have struck out on 1,353 instances (9th in the league) and have a total of 1,284 hits. The Cincinnati Reds are sitting with an OBP of .315 in addition to a team batting average of .245 on the season.

The Reds are sitting with a team WHIP of 1.233 with a FIP of 4.17 as a squad on the campaign. They sit at 8th in the league as a staff in total hits relinquished with 1,224. The Cincinnati pitching staff have surrendered 663 runs for the year while having a team ERA of 3.91 (600 earned runs relinquished). They have earned a strikeout to walk ratio of 8.60 (1,319 strikeouts vs 477 bases on balls). They have surrendered 187 HR's and they concede 4.32 runs per 9 innings (14th in MLB).

With 161 save situations, the Reds have accumulated 98 holds in addition to 22 blown saves. Cincinnati has called on relievers to take the mound in 60 save chances and they have walked away with 38 saves. Their relief pitchers have come in 164 times in high leverage situations and also on 142 occasions with runners on base. Cincinnati relievers have an inherited score percentage of 32.5% out of 212 inherited base runners. They sit at 17th in the league with a save rate of 63.3%, and they have sent 528 relievers to the mound this season.

The Cincinnati Reds have gotten 97 double plays and have earned a fielding percentage of .984 (22nd in pro baseball). The Reds have accrued 1,195 assists, 85 errors and have amassed 4,140 putouts so far this year. In 12,420 innings on the diamond, the Reds are sitting with a defensive efficiency of 71.0% (4th in baseball).

Greene (25-29 career record) holds a 3.66 earned run average and has allowed 7.0 hits per 9 innings. His strikeout to walk ratio is 3.45 and he has faced 2,037 batters so far in his MLB career. He has conceded 199 earned runs while holding a WHIP of 1.141 and a FIP of 3.6. In his career, Greene has given up 381 base knocks while he has tallied 610 strikeouts in 489 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (-160)

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