San Diego Padres vs Arizona Diamondbacks Prediction, 8/5/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Arizona Diamondbacks

Date: Tuesday, August 5, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: San Diego (-128) Arizona (+106)

The San Diego Padres (62-50) are hitting the road to Chase Field on Tuesday where they will meet the Arizona Diamondbacks (53-59). The odds on this game have the Padres at -128 and the Diamondbacks open at +106. The betting total comes in at 9. The pitchers who are expected to start will be Yu Darvish and Ryne Nelson.

As a team, the San Diego Padres are notching 4.1 runs per outing, which ranks them 24th in the league. They are sitting with 461 runs while holding a team OBP of .319. The Padres have accumulated 170 doubles as a team and have hit 95 baseballs out of the park. They have 432 RBI's as well as 937 base knocks over the course of the season, and their team batting average is at .251. San Diego is slugging .381 and have been rung up 783 times, while taking a walk on 353 occasions.

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They have accrued a K/BB ratio of 2.63 and the pitching staff has a collective WHIP of 1.21. Padres pitchers have surrendered 108 home runs in addition to 425 total runs (3rd in the league). San Diego has conceded 834 base knocks (7.6 per 9 innings) and 391 earned runs. The Padres hold a team earned run average of 3.56 on the year (3rd in the league), and the staff has rung up 953 batters. Their pitching staff has walked 363 opposing players and their FIP is 3.84 as a team on the season.

The Padres have sent 393 relievers to the mound for the season. The relief pitchers have inherited 185 base runners on the season with 29.2% of them ended up scoring. They have tallied 38 saves on the season and have blown 13 of their 51 chances to get a save. The Padres relief pitchers have accumulated a save rate of 74.5% and have come into the game in 132 save situations. The relief pitchers are sitting with 78 holds for the season (2nd in the league). Padres relief pitchers have come into the game with runners on 131 times and also have had 158 appearances in high leverage situations.

The Padres have converted 71.4% of baseballs in play into outs out of 8,901 innings, which has them sitting 2nd in baseball. The San Diego Padres have accumulated 2,967 putouts this year, as well as 847 assists and 53 errors. Their fielding percentage sits at .986 which has them ranked 14th in MLB, and they have turned 83 double plays.

Darvish has pitched in 1,729 innings and is sitting with 2,025 K's in his MLB career. Darvish (111-91 win-loss mark in his career) is the owner of a FIP of 3.56 while he has gone up against 7,112 opposing hitters in the majors. His ERA is 3.62 (695 earned runs allowed) and he has a WHIP of 1.139. He has given up 1,417 base hits (7.4 hits per nine innings) and has had 553 free passes.

The Diamondbacks hold a slugging percentage of .435 and they score 4.84 runs per game (6th in baseball). They have put up 194 doubles, while taking a walk 393 times as well as recording 542 runs. Arizona has 153 home runs so far this year and 530 runs batted in. They have struck out on 882 instances (21st in the league) and have recorded 941 base hits. The Arizona Diamondbacks have compiled an OBP of .324 in addition to a batting average of .249 so far this season.

The Arizona pitching staff have surrendered 551 runs for the season while having a team ERA of 4.58 (505 earned runs allowed). They have allowed 141 home runs and they relinquish 4.99 runs per 9 innings (25th in the league). The Diamondbacks hold a team WHIP of 1.337 in addition to having a FIP of 4.30 as a staff so far this year. They have earned a strikeout to walk ratio of 8.30 (921 strikeouts against 350 walks). They sit at 24th in MLB as a pitching staff in total hits allowed with 978.

Sitting with 107 save situations, the Diamondbacks have accrued 56 holds and also 18 blown saves. Arizona has had relief pitchers take the mound in 48 save chances and they have walked away with 30 saves. Their relief pitchers have taken the field 96 times in high leverage situations and on 89 occasions with runners on base. Arizona relievers have an inherited score percentage of 33.6% out of their 113 inherited runners. They rank 17th in the league with a save rate of 62.5%, and they have dispatched 335 relievers to the mound so far this season.

In 8,943 innings on the field, the Diamondbacks have earned a efficiency on defense of 69.0% (23rd in professional baseball). The Arizona Diamondbacks have turned 87 double plays and have a fielding rate of .986 (17th in pro baseball). The Diamondbacks have recorded 989 assists, 56 errors and have earned 2,981 putouts this season.

During his MLB career, Nelson has given up 393 hits while he has totaled 319 strikeouts in 408 innings. Nelson (25-18 career win-loss mark) is the owner of a 4.26 earned run average and has conceded 8.7 hits per nine innings. He has allowed 193 earned runs while holding a WHIP of 1.242 and being the owner of a FIP of 4.2. He has a strikeout to walk ratio of 2.80 and he has gone up against 1,702 batters during his career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Arizona (+106) and under 9 runs

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