San Diego Padres vs Chicago White Sox Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago White Sox

Date: Friday, September 19, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: San Diego (-210) Chicago (+172)

The San Diego Padres (83-69) are on their way to Rate Field on Friday where they will try to beat the Chicago White Sox (57-96). The line on this contest has San Diego at -210 and Chicago is priced at +172. The betting total is set at 8.5. The men taking the mound will be Dylan Cease and Davis Martin.

As a squad, the San Diego Padres are notching 4.3 runs per game, which puts them at 20th in MLB. They have earned 651 runs while holding a team on-base percentage of .322. The Padres have accrued 244 doubles as a squad and have knocked 140 balls out of the park. They have amassed 614 RBI's and 1,281 base knocks so far this year, while their batting average comes in at .252. San Diego is slugging .390 and have been called out on strikes 1,075 times, while drawing a walk on 484 occasions.

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They have accumulated a K/BB ratio of 2.73 and their pitching staff has earned a collective WHIP of 1.20. Padres pitchers have conceded 169 home runs and also 590 runs in total (2nd in MLB). San Diego has conceded 1,128 hits (7.6 per 9 innings) in addition to 548 earned runs. The Padres have a team ERA of 3.67 on the season (3rd in MLB), and their staff has rung up 1,332 hitters. Their pitching staff has walked 488 opposing hitters and their FIP is 4.03 as a unit so far this season.

Padres relief pitchers have gone to the mound with runners on base 173 times and also have had 198 appearances in high leverage situations. The relievers have earned 98 holds on the campaign (6th in the league). The Padres relievers have recorded a save percentage of 74.6% and have entered the game in 166 save situations. They have recorded 47 saves so far this season and have blown 16 of their 63 chances to save the game. The relief pitchers have inherited 244 runners so far this season with 29.1% of those players ended up scoring. The Padres have dispatched 536 relievers to the mound on the campaign.

The Padres have converted 71.7% of baseballs in play into outs out of their 12,087 innings, which has them sitting at 2nd in pro baseball. The San Diego Padres have earned 4,029 putouts on the year, in addition to 1,143 assists and 70 errors. Their fielding percentage is holding at .987 which has them sitting 12th in the majors, and have accumulated 107 double plays.

Cease (65-57 mark in his career) has a FIP of 3.82 and he has gone up against 4,256 opposing batters in the majors. He has surrendered 844 base hits (7.6 hits per 9 innings) and has 425 free passes. His earned run average is 3.88 (433 earned runs allowed) and he has a career WHIP of 1.264. Cease has pitched in 1,004 innings and has earned 1,217 K's in his career.

The White Sox hold a team slugging percentage of .373 and they earn 3.98 runs per contest (26th in the league). They have put up 231 doubles, while getting a free base 472 times as well as putting up 609 runs. Chicago has a total of 154 home runs so far this year as well as 588 runs batted in. They have been called out on strikes on 1,287 occasions (14th in baseball) and have earned 1,184 base knocks. The Chicago White Sox have compiled an on-base percentage of .302 and a team batting average of .233 over the course of the season.

The White Sox have a WHIP of 1.362 and are the owners of a FIP of 4.49 as a unit on the campaign. Their K/BB ratio comes in at 8.00 (1,193 strikeouts against 566 walks). They rank 15th in the league as a pitching staff in total hits allowed with 1,256. They have given up 175 long balls and they concede 4.69 runs per 9 innings (21st in the league). The Chicago pitching staff have relinquished 698 runs on the season while having an ERA of 4.23 (629 earned runs allowed).

Chicago has called on relievers to enter the game in 44 save chances and they have come away with 23 saves. They rank 29th in the league with a save percentage of 52.3%, and they have dispatched 498 relievers to the hill on the campaign. Their relief pitchers have stepped onto the mound 141 times in high leverage situations and on 154 occasions with runners on. Chicago relief pitchers have an inherited score percentage of 31.8% out of their 223 inherited runners. Sitting with 110 save situations, the White Sox have compiled 64 holds in addition to 21 blown saves.

Out of their 12,045 innings on the diamond, the White Sox have accumulated a defensive efficiency of 69.8% (18th in professional baseball). The Chicago White Sox have turned 123 double plays and hold a fielding percentage of .982 (28th in professional baseball). The White Sox have 1,208 assists, 96 errors and have 4,015 putouts so far this season.

In his pro baseball career, Martin has given up 237 base knocks while he has totaled 190 K's in 245 innings pitched. Martin (9-21 win-loss record in his career) has earned a 4.29 ERA and has given up 8.7 hits per nine innings. He has allowed 117 earned runs while earning a WHIP of 1.321 and being the owner of a FIP of 4.2. He has a strikeout to walk ratio of 2.18 and he has gone up against 1,044 batters so far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-210)

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