San Diego Padres vs Houston Astros Prediction, 4/19/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Houston Astros

Date: Saturday, April 19, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: San Diego (-210) Houston (+172)

Daikin Park is the location where the Houston Astros (8-10) will try to defeat the San Diego Padres (15-4) on Saturday. The moneyline on this contest has San Diego at -210 while Houston is coming in at +172. The betting total comes in at 8.5. The pitchers who are expected to start are Michael King and Hayden Wesneski.

The Padres have recorded 32 two-baggers as a team and have smacked 19 baseballs out of the park. San Diego has a slugging rate of .417 and have been rung up 124 times, while drawing a walk on 70 occasions. As a team, the San Diego Padres are scoring 4.6 runs per game, which has them at 8th in MLB. They have accrued 80 RBI's as well as 171 hits for the year, while their average at the plate sits at .274. They have accumulated 88 runs while holding a team OBP of .348.

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The Padres are sitting with a team ERA of 2.56 on the season (2nd in MLB), and the staff has struck out 165 hitters. Padres pitchers have conceded 13 home runs and 51 runs in total (1st in the league). Their pitching staff has walked 64 opposing players and their FIP sits at 3.26 as a team on the campaign. San Diego has given up 117 hits (6.2 per 9 innings) as well as 48 earned runs. They have a K/BB ratio of 2.58 and the pitching staff has earned a collective WHIP of 1.07.

The Padres relief pitchers have accumulated a save rate of 90.0% and stepped onto the hill in 27 save situations. The bullpen pitchers have inherited 22 runners for the season and 27.3% of them ended up scoring. Padres relief pitchers have stepped onto the hill with runners on base 15 times in addition to having 29 appearances in high leverage situations. The Padres have dispatched 65 relief pitchers to the mound so far this year. The relief pitchers have 17 holds on the campaign (4th in MLB). They have compiled 9 saves on the campaign and have blown 1 of their 10 chances to get a save.

The Padres have turned 74.7% of baseballs in play into outs out of their 1,521 innings, ranking them 2nd in the majors. The San Diego Padres are sitting with 507 putouts at this point in the season, in addition to 140 assists and 9 errors. Their fielding percentage is holding steady at .986 which puts them in 13th in the majors, and have accumulated 14 double plays.

King has pitched in 443 frames and has accounted for 507 punch outs in his pro baseball career. His earned run average is 3.17 (156 earned runs allowed) and he has a WHIP of 1.187. He has conceded 372 base knocks (7.6 hits per 9 innings) and has had 154 free passes. King (29-26 career win-loss mark) has a FIP of 3.12 while he has gone up against 1,852 batters during his time in the major leagues.

The Astros have a team slugging percentage of .317 and they are recording 3.67 runs per game (23rd in MLB). They have tallied 16 doubles, while taking a walk 66 times and putting up 66 runs. Houston has compiled 14 home runs for the season to go along with 59 runs batted in. They have struck out on 152 occasions (16th in baseball) and have notched a total of 127 base knocks. The Houston Astros have compiled an on-base percentage of .300 and a batting average of .216 over the course of the season.

The Houston pitching staff have conceded 70 runs over the course of the season while holding a team ERA of 3.74 (67 earned runs yielded). They have conceded 17 homers and they allow 3.91 runs per 9 innings (9th in baseball). The Astros have a WHIP of 1.129 and have a FIP of 3.38 as a team so far this season. Their strikeout to walk ratio is 10.10 (181 strikeouts vs 59 walks). They are currently ranked 5th in baseball as a staff in total hits relinquished with 123.

Houston bullpen pitchers hold an inherited score rate of 34.8% out of their 23 inherited base runners. Their relievers have taken the field 18 times in high leverage situations and on 16 occasions with runners on base. Sitting with 20 save situations, the Astros have earned 12 holds in addition to 3 blown saves. They are currently ranked 15th in MLB with a save rate of 62.5%, and they have sent 59 relievers onto the field for the year. Houston has called on relievers to enter the contest in 8 save opportunities and they have earned 5 saves.

In their 1,455 innings on the field, the Astros have earned a defensive efficiency of 72.2% (9th in professional baseball). The Houston Astros have turned 9 double plays and have a fielding percentage of .986 (17th in MLB). The Astros have racked up 130 assists, 9 errors and have notched a total of 485 putouts so far this season.

Wesneski (10-14 career record) is the owner of a 3.94 earned run average while allowing 7.4 hits per nine innings. He has a K/BB ratio of 3.24 and he has faced 862 batters thus far in his career. He has surrendered a total of 91 earned runs while holding a WHIP of 1.130 and a FIP of 3.9. Thus far in his career, Wesneski has given up 172 base hits while he has tallied 204 punch outs in 208 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (+172)

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