San Diego Padres vs Pittsburgh Pirates Prediction, 5/2/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Pittsburgh Pirates

Date: Friday, May 2, 2025

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: San Diego (-132) Pittsburgh (+110)

The San Diego Padres (19-11) are traveling to PNC Park on Friday where they will take on the Pittsburgh Pirates (12-19). The line on this matchup has San Diego at -132 and Pittsburgh is sitting at +110. The over/under has been set at 8. The pitchers expected to start will be Dylan Cease and Mitch Keller.

The Padres have accumulated 44 doubles as a squad and have hit 26 balls out of the stadium. San Diego is slugging .391 and have struck out 202 times, while taking a walk on 96 occasions. As a unit, the San Diego Padres are putting up 3.9 runs per game, which has them sitting at 20th in the league. They have accrued 109 RBI's and 252 hits this year, and their team batting average is sitting at .259. They have 118 runs scored and hold an on-base percentage of .327.

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The Padres have an ERA of 2.86 on the campaign (2nd in MLB), and the staff has struck out 267 hitters. Padres pitchers have conceded 24 home runs and 90 runs in total (1st in baseball). Their pitching staff has walked 92 opposing batters and their FIP sits at 3.38 as a squad this year. San Diego has allowed 204 hits (7.0 per 9 innings) and also 84 earned runs. They have a K/BB ratio of 2.90 and the pitching staff has earned a collective WHIP of 1.12.

The Padres have dispatched 101 relief pitchers to the mound for the year. The relief pitchers have inherited 34 base runners for the season and 29.4% of them earned a run for their team. They have earned 13 saves this year and have blown 1 out of their 14 save opportunities. The Padres bullpen have recorded a save rate of 92.9% and have stepped onto the mound in 39 save situations. The relief pitchers have recorded 25 holds so far this season (6th in baseball). Padres bullpen pitchers have gone to the mound with opponents on base 22 times in addition to having 37 appearances in high leverage situations.

The Padres have turned 72.5% of balls hit into play into outs out of their 2,376 innings on the field, which ranks them 5th in MLB. The San Diego Padres have a total of 792 putouts so far this season, in addition to 206 assists and 14 errors. Their fielding percentage sits at .986 which ranks 15th in MLB, and have accumulated 19 double plays.

Cease has thrown 876 innings and has totaled 1,052 strikeouts so far in his MLB career. Cease (58-48 mark in his career) has a FIP of 3.76 while going up against 3,718 hitters in the major leagues. His ERA is 3.82 (372 ER's allowed) and his career WHIP is 1.266. He has allowed 738 hits (7.6 hits per 9 innings) and has 371 walks.

The Pirates hold a slugging percentage of .340 and they score 3.42 runs per game (26th in MLB). They have recorded 39 doubles, while getting a free base 109 times as well as putting up 106 runs. Pittsburgh has accounted for 23 home runs on the season and 104 RBIs. They have been called out on strikes on 274 occasions (6th in the league) and have tallied 233 hits. The Pittsburgh Pirates have accounted for an on-base percentage of .305 in addition to a team batting average of .226 over the course of the season.

The Pittsburgh pitching staff have surrendered 139 runs for the year while holding a team ERA of 4.11 (127 earned runs surrendered). They have allowed 26 dingers and they surrender 4.50 runs per 9 innings (19th in baseball). The Pirates are sitting with a team WHIP of 1.237 in addition to having a FIP of 3.77 as a staff so far this season. They have earned a strikeout to walk ratio of 7.60 (235 strikeouts against 95 free passes). They are currently ranked 19th in the league as a staff in total hits allowed with 249.

Pittsburgh relief pitchers hold an inherited score percentage of 32.7% out of 49 inherited base runners. Their relievers have stepped onto the hill 36 times in high leverage situations and on 31 occasions with base runners. With 31 save situations, the Pirates have amassed 19 holds and also 5 blown saves. They are ranked 20th in baseball holding a save percentage of 58.3%, and they have dispatched 104 bullpen pitchers to the hill so far this year. Pittsburgh has called on relievers to step onto the hill in 12 save opportunities and they have walked away with 7 saves.

In 2,505 innings played, the Pirates have accumulated a efficiency on defense of 70.2% (14th in pro baseball). The Pittsburgh Pirates have gotten 27 double plays and have a fielding rate of .979 (26th in MLB). The Pirates have recorded 285 assists, 24 errors and have amassed 835 putouts during this campaign.

In his MLB career, Keller has allowed 776 hits while totaling 713 strikeouts in 735 innings. He has surrendered 373 earned runs while earning a WHIP of 1.408 and being the owner of a FIP of 4.5. His K/BB ratio is 2.75 and he has gone up against 3,218 opposing batters in his pro baseball career. Keller (37-52 career mark) holds a 4.57 earned run average while giving up 9.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Pittsburgh (+110)

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