San Diego Padres vs St. Louis Cardinals Prediction, 7/27/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs St. Louis Cardinals

Date: Sunday, July 27, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: San Diego (-130) St. Louis (+110)

The San Diego Padres (55-48) are traveling to Busch Stadium on Sunday where they will attempt to defeat the St. Louis Cardinals (53-51). The moneyline on this contest has San Diego at -130 and St. Louis opens at +110. The over/under is set at 9. The pitchers taking the mound will be Stephen Kolek and Michael McGreevy.

As a unit, the San Diego Padres are scoring 4.0 runs per game, which has them at 25th in baseball. They have racked up 414 runs and hold an OBP of .315. The Padres have compiled 156 doubles as a squad and have hit 88 baseballs out of the park. They have accumulated 388 runs batted in as well as 843 base knocks this year, while their average at the plate comes in at .246. San Diego has a slugging % of .376 and have struck out 729 times, while drawing a walk on 327 occasions.

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Their strikeout to walk ratio is 2.56 and their pitching staff has recorded a WHIP of 1.24. Padres pitchers have yielded 103 home runs and also 400 runs (5th in baseball). San Diego has conceded 785 base knocks (7.8 per 9 innings) as well as 367 earned runs. The Padres have compiled a team earned run average of 3.63 on the campaign (7th in baseball), and the staff has rung up 874 batters. They have walked 341 players from the other team and their FIP comes in at 3.90 as a unit on the campaign.

The Padres bullpen have compiled a save rate of 74.5% and have come into the game in 119 save situations. The relief pitchers have inherited 174 runners this year with 29.3% of those players ended up scoring. Padres relief pitchers have gone to the mound with runners on base 124 times and also have had 150 appearances in high leverage situations. The Padres have sent 361 relief pitchers to the hill on the campaign. The bullpen have earned 70 holds on the season (6th in the league). They have recorded 35 saves for the year and have blown 12 out of their 47 chances to save the game.

The Padres have transformed 70.9% of balls hit into play into outs in their 8,181 innings on the diamond, which has them sitting at 9th in professional baseball. The San Diego Padres have accumulated 2,727 putouts so far this season, as well as 782 assists and 51 errors. Their fielding percentage is at .986 which has them sitting 19th in pro baseball, and they have turned 77 double plays.

Kolek (6-5 career record) has a FIP of 4.60 while going up against 523 batters during his time in the major leagues. He has allowed 133 base knocks (10.0 hits per nine innings) and has had 35 free passes. His ERA is 4.67 (62 earned runs allowed) and he has a WHIP of 1.407. Kolek has taken the ball for 119 innings and has racked up 93 strikeouts so far in his career.

St. Louis has accumulated 103 long balls so far this year as well as 449 runs batted in. They have put up 184 two-baggers, while taking a walk 324 times as well as putting up 470 runs. The St. Louis Cardinals have an OBP of .322 in addition to a batting average of .253 for the year. The Cardinals hold a team slugging % of .396 and they have an average of 4.52 runs per outing (13th in MLB). They have been called out on strikes on 800 instances (24th in baseball) and have recorded 893 base hits.

The Cardinals are sitting with a team WHIP of 1.288 and have a FIP of 3.86 as a team so far this season. They come in at 25th in MLB as a pitching staff in total hits relinquished with 903. The St. Louis pitching staff have yielded 472 runs on the year while having an ERA of 4.23 (432 earned runs conceded). Their strikeout to walk ratio comes in at 7.50 (766 strikeouts against 280 bases on balls). They have relinquished 101 home runs and they relinquish 4.63 runs per 9 innings (22nd in MLB).

With 102 save situations, the Cardinals have recorded 60 holds in addition to 14 blown saves. St. Louis has called on relievers to take the mound in 39 save chances and they have walked away with 25 saves. Their relievers have stepped onto the hill 103 times in high leverage situations and also on 100 occasions with base runners. St. Louis bullpen pitchers have an inherited score rate of 33.8% out of their 136 inherited runners. They rank 14th in baseball with a save percentage of 64.1%, and they have sent 310 relief pitchers onto the diamond on the season.

The St. Louis Cardinals have gotten 78 double plays and have earned a fielding percentage of .989 (4th in the majors). The Cardinals have recorded 1,000 assists, 42 errors and have accounted for 2,756 putouts for the season. Out of their 8,268 innings played, the Cardinals have a defensive efficiency of 69.5% (19th in professional baseball).

During his MLB career, McGreevy has conceded 42 hits while earning 35 punch outs in 51 innings. He has allowed 16 earned runs while earning a WHIP of 0.920 and being the owner of a FIP of 2.8. He has a K/BB ratio of 7.00 and he has faced 198 batters thus far in his career. McGreevy (5-1 win-loss mark in his career) has a 2.82 ERA and has surrendered 7.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take St. Louis (+110) and under 9 runs

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