San Francisco Giants vs Los Angeles Dodgers Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Los Angeles Dodgers

Date: Sunday, September 21, 2025

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: San Francisco (+162) Los Angeles (-196)

The Los Angeles Dodgers (86-67) welcome the San Francisco Giants (76-77) at Dodger Stadium on Sunday. The odds on this game have San Francisco at +162 and Los Angeles is coming in at -196. The over/under is set at 9. The expected starting pitchers will be Kai-Wei Teng and Tyler Glasnow.

The Giants have compiled 225 two-baggers as a unit and have hit 162 balls out of the park. San Francisco has a slugging percentage of .385 and have been called out on strikes 1,303 times, while drawing a walk on 521 occasions. As a team, the San Francisco Giants are notching 4.3 runs per contest, which has them sitting at 17th in MLB. They have tallied 633 RBI's as well as 1,193 hits so far this season, and their batting average is .235. They have a total of 663 runs scored while holding a team OBP of .311.

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The Giants have a team ERA of 3.83 so far this season (9th in the league), and the staff has struck out 1,275 batters. Giants pitchers have given up 129 home runs in addition to 646 total runs (12th in baseball). They have walked 483 opposing hitters and their FIP is 3.72 as a unit on the year. San Francisco has surrendered 1,281 hits (8.5 per 9 innings) and 576 earned runs. They have earned a K/BB ratio of 2.64 and their pitching staff has earned a collective WHIP of 1.30.

The Giants bullpen have recorded a save rate of 65.5% and have come into the game in 134 save situations. The relief pitchers have inherited 181 base runners so far this year and 37.6% of them earned a run for their team. Giants pitchers have gone to the mound with opponents on base 115 times in addition to having 162 appearances in high leverage situations. The Giants have sent 485 relievers to the hill for the season. The relief pitchers have earned 79 holds for the season (20th in the league). They have recorded 36 saves on the season and have blown 19 of 55 chances to get a save.

The Seattle Mariners have earned a total of 4,040 putouts for the season, as well as 1,426 assists and 90 errors. Their fielding percentage is currently at .984 which ranks 25th in professional baseball, and they have turned 125 double plays. The Giants have converted 68.2% of balls in play into outs out of 12,120 innings, which has them sitting at 27th in MLB.

Teng has thrown 37 frames and has accumulated 40 strikeouts during his MLB career. Teng (2-4 win-loss mark in his career) is the owner of a FIP of 7.39 while he has faced 179 opposing hitters in the majors. His earned run average is 7.50 (31 earned runs allowed) and his WHIP is 1.774. He has given up 43 hits (10.4 hits per nine innings) and has had 23 free passes.

The Los Angeles Dodgers have tallied an OBP of .329 as well as a batting average of .254 on the campaign. They have been called out on strikes on 1,272 occasions (15th in the league) and have recorded 1,313 base hits. Los Angeles has knocked in 225 long balls on the year to go along with 747 RBIs. The Dodgers have a team slugging % of .439 and they tally 5.10 runs per game (3rd in baseball). They have hit 244 doubles, while walking 557 times as well as notching 780 runs.

The Los Angeles pitching staff have yielded 657 runs on the campaign while holding a team ERA of 4.03 (608 earned runs yielded). They have allowed 171 dingers and they surrender 4.35 runs per 9 innings (15th in MLB). The Dodgers have a team WHIP of 1.265 and have a FIP of 4.04 as a staff so far this year. They currently have a strikeout to walk ratio of 9.30 (1,397 strikeouts vs 533 free passes). They come in at 5th in the league as a staff in total hits allowed with 1,185.

Los Angeles bullpen pitchers hold an inherited score rate of 26.1% out of 218 inherited runners. Their relievers have taken the field 169 times in high leverage situations and on 140 occasions with base runners. Sitting with 183 save situations, the Dodgers have earned 114 holds and 24 blown saves. They are ranked 17th in baseball holding a save rate of 62.5%, and they have sent 543 bullpen pitchers to the hill for the season. Los Angeles has had relief pitchers step onto the hill in 64 save chances and they have converted 40 saves.

The Los Angeles Dodgers have turned 97 double plays and have accounted for a fielding rate of .988 (6th in baseball). The Dodgers have recorded 1,272 assists, 64 errors and are sitting with 4,048 putouts during this campaign. In 12,144 innings on the field, the Dodgers have earned a defensive efficiency of 70.4% (10th in professional baseball).

In his MLB career, Glasnow has given up 566 base knocks while accumulating 942 strikeouts in 745 innings. He has conceded 309 earned runs while earning a WHIP of 1.142 and being the owner of a FIP of 3.7. He has a K/BB ratio of 3.31 and he has gone up against 3,048 opposing batters during his MLB career. Glasnow (42-36 career win-loss mark) is the owner of a 3.73 ERA and has given up 6.8 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Los Angeles (-196) and under 9 runs

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