Seattle Mariners vs Chicago Cubs Prediction, 6/21/2025 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Chicago Cubs

Date: Saturday, June 21, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Seattle (+162) Chicago (-196)

The Chicago Cubs (45-28) will try to defeat the Seattle Mariners (37-36) at Wrigley Field on Saturday. The moneyline on this matchup has the Mariners at +162 while the Cubs are coming in at -196. The betting total comes in at 8.5. The pitchers taking the mound are Emerson Hancock and Matthew Boyd.

As a unit, the Seattle Mariners are notching 4.3 runs per contest, which has them at 12th in MLB. They have earned a total of 317 runs while holding a team on-base percentage of .322. The Mariners have tallied 98 two-baggers as a squad and have knocked 91 baseballs out of the park. They have amassed 306 runs batted in as well as 600 base knocks over the course of the season, and their team batting average is sitting at .242. Seattle is slugging .394 and have been called out on strikes 649 times, while drawing a walk on 265 occasions.

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The Mariners hold a team ERA of 3.87 on the campaign (15th in MLB), and they have rung up 596 hitters. Mariners pitchers have given up 84 long balls in addition to 315 runs in total (19th in the league). They have walked 223 hitters and their FIP sits at 4.05 as a team for the year. Seattle has allowed 625 base hits (8.5 per 9 innings) in addition to 284 earned runs. Their strikeout to walk ratio is 2.67 and the pitching staff has earned a collective WHIP of 1.28.

Mariners bullpen pitchers have stepped onto the hill with runners on base 52 times as well as having 96 appearances in high leverage situations. The relief pitchers have a total of 34 holds for the season (27th in the league). The Mariners relievers have recorded a save percentage of 61.3% and have entered the game in 65 save situations. They have earned 19 saves for the season and have blown 12 out of their 31 chances to save the game. The bullpen pitchers have inherited 59 base runners this year and 25.4% of those players earned a run for their team. The Mariners have sent 245 relievers to the hill for the year.

The San Francisco Giants have 1,983 putouts this year, as well as 637 assists and 28 errors. Their fielding percentage is currently at .989 which has them ranked 3rd in MLB, and have a total of 63 double plays. The Mariners have turned 70.0% of balls hit into play into outs out of 5,949 innings, which ranks them 17th in the majors.

Hancock has pitched in 134 innings and is sitting with 90 punch outs so far in his pro baseball career. Hancock (7-6 win-loss record in his career) has a FIP of 4.55 while he has faced 577 hitters in the major leagues. His ERA is 4.62 (69 earned runs allowed) and his WHIP is 1.363. He has surrendered 140 hits (9.4 hits per nine innings) and has 43 walks.

Chicago has hit 99 home runs over the course of the season to go along with 382 RBIs. They have 133 doubles, while getting a free base 255 times as well as scoring 390 runs. The Chicago Cubs have a team OBP of .324 in addition to a batting average of .254 this year. The Cubs hold a slugging percentage of .436 and they are recording 5.34 runs per outing (2nd in the league). They have been called out on strikes on 579 occasions (21st in baseball) and have earned a total of 643 hits.

The Cubs have a WHIP of 1.223 and have a FIP of 3.87 as a team on the campaign. They have earned a K/BB ratio of 7.80 (566 strikeouts against 205 bases on balls). They are sitting at 16th in the league as a staff in total hits allowed with 595. They have allowed 75 home runs and they concede 3.89 runs per 9 innings (9th in MLB). The Chicago pitching staff have surrendered 283 runs on the season while having a team ERA of 3.56 (259 earned runs surrendered).

Sitting with 77 save situations, the Cubs have compiled 49 holds in addition to 8 blown saves. Chicago has had bullpen pitchers take the mound in 26 save opportunities and they have come away with 18 saves. Their relievers have stepped onto the mound 88 times in high leverage situations and also on 55 occasions with runners on base. Chicago bullpen pitchers hold an inherited score rate of 31.1% out of their 74 inherited base runners. They are currently ranked 8th in MLB with a save percentage of 69.2%, and they have sent 246 relievers to the hill for the season.

In 5,892 innings on the diamond, the Cubs have earned a efficiency on defense of 70.8% (10th in pro baseball). The Chicago Cubs have turned 64 double plays and have a fielding percentage of .988 (6th in MLB). The Cubs have 631 assists, 31 errors and have a tally of 1,964 putouts for the season.

So far in his pro baseball career, Boyd has surrendered 974 base hits while he has totaled 964 punch outs in 988 innings. Boyd (52-72 win-loss record in his career) is the owner of a 4.68 ERA while surrendering 8.9 hits per 9 innings. He has conceded a total of 514 earned runs while earning a WHIP of 1.302 and having a FIP of 4.6. He has a K/BB ratio of 3.08 and he has faced 4,223 batters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Seattle (+162)

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