Seattle Mariners vs Chicago White Sox Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Chicago White Sox

Date: Wednesday, May 21, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Seattle (-132) Chicago (+110)

The Chicago White Sox (14-34) will take on the Seattle Mariners (27-19) at Rate Field on Wednesday. The odds on this game have the Mariners at -132 while the White Sox are opening at +110. The total is set at 9. The pitchers expected to start will be Logan Evans and Shane Smith.

Seattle is slugging .400 and have been called out on strikes 409 times, while taking a walk on 182 occasions. They have 213 runs batted in and 371 hits for the year, while their average at the plate is sitting at .238. The Mariners have compiled 59 two-baggers as a squad and have knocked 63 balls out of the stadium. They have a total of 221 runs scored and hold an OBP of .325. As a unit, the Seattle Mariners are recording 4.8 runs per game, which has them at 8th in baseball.

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They have earned a strikeout to walk ratio of 2.53 and the pitching staff has a collective WHIP of 1.31. Mariners pitchers have conceded 44 home runs in addition to 194 total runs (14th in the league). Seattle has relinquished 399 base hits (8.5 per 9 innings) as well as 171 earned runs. The Mariners have compiled a team ERA of 3.66 on the year (11th in the league), and they have struck out 380 batters. Their pitching staff has walked 150 opposing hitters and their FIP sits at 3.81 as a unit so far this season.

Mariners pitchers have entered the game with opponents on base 39 times and also have had 67 appearances in high leverage situations. The relief pitchers are sitting with 26 holds this year (18th in MLB). The Mariners relief pitchers have a save percentage of 66.7% and have entered the game in 50 save situations. They have accumulated 16 saves this year and have not converted 8 of their 24 chances to get a save. The relief pitchers have inherited 44 runners this year with 27.3% of those runners crossed the plate. The Mariners have dispatched 163 relief pitchers to the mound on the year.

The Mariners have transformed 69.5% of balls in play into outs out of their 3,786 innings on the diamond, which has them sitting 18th in professional baseball. The San Francisco Giants have a tally of 1,262 putouts so far this season, as well as 413 assists and 19 errors. Their fielding percentage sits at .989 which has them ranked 6th in professional baseball, and have accumulated 33 double plays.

Evans has thrown 21 innings and is sitting with 14 K's so far in his MLB career. Evans (2-1 career mark) is the owner of a FIP of 2.53 while he has gone up against 93 hitters in the major leagues. His earned run average is 2.57 (6 earned runs allowed) and his career WHIP is 1.524. He has allowed 24 base hits (10.3 hits per nine innings) with 8 walks.

The Chicago White Sox hold a team OBP of .287 as well as a team batting average of .216 for the year. They have struck out on 405 occasions (11th in baseball) and have tallied 335 hits. Chicago has accounted for 37 home runs so far this year to go along with 153 RBIs. The White Sox hold a slugging % of .328 and they score 3.29 runs per game (29th in MLB). They have hit 62 two-baggers, while walking 148 times as well as scoring 158 runs.

The Chicago pitching staff have conceded 215 runs this year while holding an ERA of 4.25 (194 earned runs conceded). They have surrendered 51 homers and they yield 4.71 runs per 9 innings (23rd in MLB). The White Sox have a WHIP of 1.408 and have a FIP of 4.58 as a unit on the season. Their K/BB ratio sits at 7.50 (341 strikeouts against 180 bases on balls). They come in at 19th in the league as a staff in total hits surrendered with 399.

Chicago bullpen pitchers hold an inherited score rate of 34.3% out of their 70 inherited base runners. Their bullpen pitchers have stepped onto the mound 38 times in high leverage situations and also on 49 occasions with base runners. With 30 save situations, the White Sox have compiled 20 holds and also 7 blown saves. They sit at 30th in baseball holding a save rate of 30.0%, and they have sent 156 bullpen pitchers onto the diamond on the campaign. Chicago has called on bullpen pitchers to enter the contest in 10 save chances and they have converted 3 saves.

In 3,702 innings on the diamond, the White Sox are sitting with a efficiency on defense of 69.3% (21st in pro baseball). The Chicago White Sox have gotten 38 double plays and have a fielding percentage of .979 (28th in baseball). The White Sox have 389 assists, 35 errors and have 1,234 putouts so far this year.

So far in his pro baseball career, Smith has allowed 39 base knocks while totaling 43 strikeouts in 48 frames. Smith (1-3 record in his career) has a 2.06 earned run average and has surrendered 7.3 hits per nine innings. He has allowed 11 ER's while holding a WHIP of 1.143 and having a FIP of 2.0. He has a strikeout to walk ratio of 2.69 and he has faced 202 batters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+110)

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