St. Louis Cardinals vs Chicago Cubs Prediction, 7/5/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago Cubs

Date: Saturday, July 5, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: St. Louis (+110) Chicago (-132)

Wrigley Field is the site where the Chicago Cubs (51-35) will take on the St. Louis Cardinals (47-41) on Saturday. The odds on this game have St. Louis at +110 while Chicago is sitting at -132. The betting total is set at 8.5. The expected starting pitchers are Matthew Liberatore and Jameson Taillon.

As a team, the St. Louis Cardinals are scoring 4.6 runs per outing, which puts them at 11th in baseball. They have racked up 403 runs while holding a team on-base percentage of .323. The Cardinals have tallied 151 doubles as a unit and have hit 87 balls out of the park. They have recorded 383 runs batted in and 754 base knocks over the course of the season, while their team batting average is sitting at .253. St. Louis owns a slugging percentage of .393 and have been called out on strikes 682 times, while drawing a walk on 276 occasions.

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Their strikeout to walk ratio is 2.67 and the pitching staff has a collective WHIP of 1.26. Cardinals pitchers have surrendered 73 long balls in addition to 371 runs in total (17th in the league). St. Louis has given up 741 base knocks (8.5 per 9 innings) as well as 342 earned runs. The Cardinals are sitting with a team earned run average of 3.94 for the season (17th in the league), and their staff has rung up 640 hitters. They have walked 240 opposing batters and their FIP comes in at 3.68 as a unit so far this year.

Cardinals relief pitchers have come into the game with runners on 86 times in addition to having 95 appearances in high leverage situations. The relief pitchers have a total of 50 holds for the year (13th in the league). The Cardinals relief pitchers have accumulated a save percentage of 63.6% and have come into the game in 86 save situations. They have compiled 21 saves on the year and have blown 12 out of their 33 save chances. The bullpen pitchers have inherited 114 runners so far this year and 34.2% of those players earned a run for their team. The Cardinals have sent 261 relievers to the mound so far this year.

The Cardinals have transformed 70.2% of balls in play into outs out of 7,035 innings on the diamond, which ranks them 15th in baseball. The St. Louis Cardinals have 2,345 putouts on the year, as well as 855 assists and 32 errors. Their fielding rate is holding at .990 which puts them in 2nd in MLB, and have earned 64 double plays.

Liberatore (14-18 win-loss mark in his career) is the owner of a FIP of 4.49 and he has faced 1,175 hitters in the major leagues. He has allowed 279 hits (9.2 hits per 9 innings) and has 88 free passes. His earned run average is 4.56 (139 ER's allowed) and his WHIP is 1.338. Liberatore has thrown 274 innings and has earned 226 punch outs during his MLB career.

The Chicago Cubs have compiled a team on-base percentage of .327 and a team batting average of .257 for the season. They have struck out on 669 occasions (25th in MLB) and have earned a total of 764 base hits. Chicago has a total of 125 home runs on the year and 454 RBIs. The Cubs hold a slugging percentage of .446 and they tally 5.38 runs per game (2nd in MLB). They have tallied 151 doubles, while getting a free base 301 times and scoring 463 runs.

The Chicago pitching staff have allowed 355 runs on the year while holding a team ERA of 3.84 (327 earned runs yielded). They have yielded 103 homers and they concede 4.16 runs per 9 innings (14th in the league). The Cubs have a team WHIP of 1.240 in addition to having a FIP of 4.20 as a unit on the season. Their K/BB ratio comes in at 7.50 (641 strikeouts against 235 free passes). They rank 16th in the league as a pitching staff in total hits conceded with 716.

Sitting with 89 save situations, the Cubs have earned 56 holds in addition to 9 blown saves. Chicago has had relief pitchers enter the contest in 30 save chances and they have come away with 21 saves. Their relievers have come in 91 times in high leverage situations and also on 61 occasions with base runners. Chicago bullpen pitchers hold an inherited score percentage of 31.7% out of their 82 inherited base runners. They rank 6th in the league holding a save rate of 70.0%, and they have dispatched 286 relief pitchers onto the field so far this season.

The Chicago Cubs have gotten 73 double plays and have a fielding percentage of .988 (7th in MLB). The Cubs have racked up 735 assists, 37 errors and have a tally of 2,303 putouts for the season. In their 6,909 innings played, the Cubs have accumulated a defensive efficiency of 71.0% (6th in professional baseball).

During his pro baseball career, Taillon has allowed 1,158 base hits while he has accumulated 1,049 K's in 1,202 innings pitched. He has given up 526 ER's while holding a WHIP of 1.202 and having a FIP of 3.9. He has a K/BB ratio of 3.66 and he has faced 4,997 batters during his career. Taillon (78-59 career record) has earned a 3.94 earned run average and has conceded 8.7 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-132) and under 8.5 runs

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