St. Louis Cardinals vs Chicago White Sox Prediction, 6/17/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago White Sox

Date: Tuesday, June 17, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: St. Louis (-210) Chicago (+172)

The St. Louis Cardinals (37-35) are headed to Rate Field on Tuesday where they will compete against the Chicago White Sox (23-49). The line on this matchup has St. Louis at -210 while Chicago is sitting at +172. The total comes in at 8.5. The pitchers expected to start will be Matthew Liberatore and Shane Smith.

As a team, the St. Louis Cardinals are notching 4.6 runs per game, which has them at 11th in MLB. They have notched a total of 328 runs scored and have an on-base percentage of .326. The Cardinals have accrued 125 two-baggers as a team and have hit 66 balls out of the park. They have amassed 312 runs batted in in addition to 624 hits so far this year, while their average at the plate is sitting at .255. St. Louis owns a slugging percentage of .391 and have been rung up 562 times, while drawing a walk on 228 occasions.

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Their strikeout to walk ratio is 2.66 and the pitching staff has a collective WHIP of 1.28. Cardinals pitchers have conceded 59 home runs and 310 total runs (20th in the league). St. Louis has yielded 623 hits (8.8 per 9 innings) and 283 earned runs. The Cardinals have a team ERA of 3.99 on the year (20th in MLB), and they have rung up 516 hitters. They have walked 194 hitters and their FIP sits at 3.68 as a unit for the year.

The Cardinals relief pitchers have accumulated a save rate of 60.7% and have entered the game in 75 save situations. The relief pitchers have inherited 94 base runners on the year with 36.2% of those players crossed the plate. Cardinals relief pitchers have gone to the mound with players on base 72 times as well as having 82 appearances in high leverage situations. The Cardinals have sent 215 relievers to the hill for the year. The relief pitchers have recorded 44 holds on the campaign (14th in the league). They have recorded 17 saves so far this season and have blown 11 of their 28 chances to get a save.

The Cardinals have turned 69.5% of balls in play into outs out of their 5,739 innings on the field, which has them sitting 18th in baseball. The St. Louis Cardinals have accounted for 1,913 putouts on the year, in addition to 697 assists and 27 errors. Their fielding rate is holding at .990 which ranks 2nd in baseball, and have accumulated 53 double plays.

Liberatore has thrown 255 innings and has accounted for 212 punch outs in his MLB career. Liberatore (11-18 career mark) is the owner of a FIP of 4.69 and he has faced 1,100 hitters in the major leagues. His earned run average is 4.76 (135 ER's allowed) and his WHIP is 1.360. He has surrendered 265 hits (9.3 hits per 9 innings) and has had 82 free passes.

The Chicago White Sox have an on-base percentage of .295 in addition to a batting average of .222 so far this season. They have struck out on 628 occasions (7th in the league) and have totaled 523 base knocks. Chicago has hit 55 home runs so far this season as well as 238 runs batted in. The White Sox have a SLG% of .343 and they are scoring 3.44 runs per contest (27th in baseball). They have 111 two-baggers, while getting a free base 235 times and notching 248 runs.

The White Sox hold a team WHIP of 1.398 and have a FIP of 4.45 as a staff so far this season. They have earned a K/BB ratio of 7.50 (521 strikeouts against 265 bases on balls). They come in at 19th in MLB as a staff in total hits surrendered with 603. They have given up 75 homers and they relinquish 4.49 runs per 9 innings (21st in the league). The Chicago pitching staff have relinquished 310 runs on the season while holding an ERA of 4.13 (285 earned runs allowed).

Chicago has had relief pitchers enter the contest in 19 save chances and they have converted 7 saves. They are currently ranked 30th in MLB holding a save rate of 36.8%, and they have sent 229 bullpen pitchers onto the field for the season. Their relievers have stepped onto the mound 66 times in high leverage situations in addition to 69 occasions with base runners. Chicago relievers have an inherited score percentage of 28.6% out of 98 inherited runners. Sitting with 54 save situations, the White Sox have accrued 35 holds and also 12 blown saves.

In 5,592 innings on the field, the White Sox have earned a efficiency on defense of 69.3% (20th in pro baseball). The Chicago White Sox have gotten 60 double plays and have earned a fielding percentage of .982 (26th in the majors). The White Sox have accrued 583 assists, 44 errors and have notched a total of 1,864 putouts for the season.

During his MLB career, Smith has surrendered 53 hits while he has tallied 64 punch outs in 68 innings pitched. He has conceded a total of 18 earned runs while earning a WHIP of 1.175 and being the owner of a FIP of 2.3. He has a K/BB ratio of 2.37 and he has faced 286 batters during his MLB career. Smith (3-3 win-loss record in his career) has earned a 2.38 earned run average while giving up 7.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+172)

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