St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/14/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Sunday, September 14, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: St. Louis (+106) Milwaukee (-128)

American Family Field is the site where the Milwaukee Brewers (89-58) will take on the St. Louis Cardinals (72-75) on Sunday. The moneyline on this contest has St. Louis at +106 and Milwaukee opens at -128. The total comes in at 8.5. The expected starting pitchers will be Miles Mikolas and Jacob Misiorowski.

The Cardinals have earned 234 two-baggers as a squad and have knocked 138 balls out of the park. St. Louis has a slugging percentage of .379 and have struck out 1,185 times, while drawing a walk on 433 occasions. As a unit, the St. Louis Cardinals are recording 4.3 runs per outing, which has them sitting at 22nd in the league. They have 599 runs batted in as well as 1,206 base knocks for the season, while their team batting average is sitting at .244. They have racked up 629 runs scored and hold an on-base percentage of .313.

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The Cardinals have a team ERA of 4.26 so far this season (21st in the league), and the staff has struck out 1,086 batters. Cardinals pitchers have allowed 151 home runs and also 675 total runs (22nd in MLB). They have walked 415 players from the other team and their FIP comes in at 4.04 as a team on the year. St. Louis has given up 1,293 hits (9.0 per 9 innings) and 615 earned runs. Their strikeout to walk ratio sits at 2.62 and the pitching staff holds a collective WHIP of 1.31.

Cardinals pitchers have gone to the mound with players on base 141 times as well as having 140 appearances in high leverage situations. The relief pitchers have 82 holds on the year (14th in baseball). The Cardinals bullpen have compiled a save rate of 65.5% and have stepped onto the mound in 143 save situations. They have accumulated 38 saves on the campaign and have blown 20 of their 58 save opportunities. The relief pitchers have inherited 195 base runners this season and 32.8% of them crossed home plate. The Cardinals have sent 434 relief pitchers to the hill on the season.

The Cardinals have turned 69.1% of balls hit into play into outs out of their 11,706 innings on the field, which has them sitting 21st in baseball. The St. Louis Cardinals have notched a total of 3,902 putouts so far this season, as well as 1,414 assists and 71 errors. Their fielding percentage sits at .987 which puts them in 11th in MLB, and they have turned 116 double plays.

Mikolas has thrown 1,237 innings and has racked up 883 K's in his pro baseball career. Mikolas (71-74 career win-loss record) holds a FIP of 4.17 while facing 5,154 opposing hitters during his time in the major leagues. His earned run average is 4.23 (582 earned runs allowed) and his career WHIP is 1.216. He has allowed 1,261 base hits (9.2 hits per 9 innings) and has had 243 walks.

Milwaukee has a total of 157 HRs over the course of the season to go along with 689 runs batted in. They have put up 239 two-baggers, while walking 504 times as well as putting up 743 runs. The Milwaukee Brewers have accounted for an OBP of .333 and a batting average of .260 for the year. The Brewers have a SLG% of .408 and they have an average of 5.05 runs per outing (3rd in the league). They have been rung up on 1,147 instances (25th in baseball) and have recorded 1,300 hits.

The Brewers hold a team WHIP of 1.232 and are the owners of a FIP of 3.92 as a staff for the season. They are sitting at 3rd in baseball as a staff in total hits relinquished with 1,124. The Milwaukee pitching staff have allowed 576 runs for the season while holding an ERA of 3.63 (527 earned runs conceded). They have earned a strikeout to walk ratio of 8.90 (1,290 strikeouts vs 485 walks). They have surrendered 152 homers and they concede 3.97 runs per 9 innings (4th in the league).

Milwaukee relievers hold an inherited score percentage of 29.7% of 192 inherited base runners. Their relievers have stepped onto the hill 169 times in high leverage situations and on 129 occasions with runners on. With 165 save situations, the Brewers have earned 100 holds and 19 blown saves. They are currently ranked 6th in the league holding a save percentage of 68.9%, and they have sent 494 relievers to the mound so far this year. Milwaukee has called on relief pitchers to take the mound in 61 save chances and they have converted 42 saves.

The Milwaukee Brewers have turned 107 double plays and hold a fielding percentage of .987 (9th in baseball). The Brewers have accrued 1,172 assists, 65 errors and have a tally of 3,920 putouts so far this season. In 11,760 innings played, the Brewers have accumulated a defensive efficiency of 70.9% (4th in professional baseball).

Thus far in his career, Misiorowski has surrendered 36 hits and he has 77 K's in 55 innings pitched. He has conceded a total of 25 ER's while holding a WHIP of 1.091 and a FIP of 4.0. His strikeout to walk ratio is 3.21 and he has faced 220 hitters during his career. Misiorowski (5-2 career win-loss mark) is the owner of a 4.09 ERA while giving up 5.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Milwaukee (-128) and under 8.5 runs

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