Tampa Bay Rays vs Baltimore Orioles Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Tampa Bay Rays vs Baltimore Orioles

Date: Tuesday, September 23, 2025

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Tampa Bay (-145) Baltimore (+125)

Oriole Park at Camden Yards is where the Baltimore Orioles (73-83) will attempt to beat the Tampa Bay Rays (76-80) on Tuesday. The odds on this game have the Rays at -145 while the Orioles are coming in at +125. The over/under has been set at 8.5. The starting pitchers will be Ryan Pepiot and Dean Kremer.

As a unit, the Tampa Bay Rays are recording 4.5 runs per game, which puts them at 15th in the league. They have earned a total of 689 runs scored while holding a team OBP of .314. The Rays have recorded 234 doubles as a team and have smacked 176 balls out of the stadium. They have accumulated 657 runs batted in and 1,315 base knocks on the year, while their average at the plate is at .251. Tampa Bay owns a slugging percentage of .403 and have struck out 1,331 times, while taking a walk on 448 occasions.

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They have earned a K/BB ratio of 3.02 and their pitching staff has a team WHIP of 1.21. Rays pitchers have given up 195 home runs and also 644 runs (10th in MLB). Tampa Bay has surrendered 1,214 base hits (8.0 per 9 innings) as well as 588 earned runs. The Rays have an ERA of 3.85 for the season (11th in the league), and the staff has rung up 1,348 batters. Their pitching staff has walked 447 players from the other team and their FIP is 4.15 as a unit so far this year.

Rays bullpen pitchers have come into the game with runners on 108 times and also have had 152 appearances in high leverage situations. The relievers have 85 holds for the year (16th in the league). The Rays bullpen have earned a save percentage of 55.6% and have entered the game in 150 save situations. They have recorded 35 saves this season and have not converted 28 out of their 63 save chances. The relief pitchers have inherited 160 runners so far this year and 31.3% of those runners ended up crossing the plate. The Rays have sent 497 relievers to the mound on the campaign.

The Rays have converted 70.7% of balls hit into play into outs out of their 12,360 innings, which has them sitting at 6th in pro baseball. The Tampa Bay Rays have earned a total of 4,120 putouts for the season, as well as 1,365 assists and 78 errors. Their fielding percentage is holding steady at .986 which is 15th in the majors, and have 142 double plays.

Pepiot has taken the hill for 372 innings and is sitting with 386 strikeouts so far in his career. Pepiot (24-20 career mark) holds a FIP of 3.45 while he has gone up against 1,524 opposing batters in the majors. His earned run average is 3.51 (145 ER's allowed) and his career WHIP is 1.144. He has conceded 286 hits (6.9 hits per nine innings) and has 140 walks.

The Orioles have a team slugging percentage of .396 and they average 4.23 runs per contest (22nd in the league). They have recorded 246 doubles, while walking 455 times as well as recording 655 runs. Baltimore has recorded 181 home runs so far this season to go along with 622 runs batted in. They have been rung up on 1,386 occasions (4th in baseball) and have totaled 1,235 hits. The Baltimore Orioles have accumulated an on-base percentage of .306 and a batting average of .238 on the campaign.

The Orioles have a WHIP of 1.367 and are the owners of a FIP of 4.41 as a unit for the year. Their K/BB ratio is 8.40 (1,285 strikeouts vs 502 free passes). They come in at 26th in the league as a pitching staff in total hits relinquished with 1,373. They have surrendered 205 dingers and they allow 4.94 runs per 9 innings (24th in MLB). The Baltimore pitching staff have allowed 753 runs on the season while holding an ERA of 4.60 (701 earned runs relinquished).

Baltimore bullpen pitchers hold an inherited score percentage of 26.1% out of their 207 inherited runners. Their relievers have come in 163 times in high leverage situations and also on 149 occasions with runners on base. With 167 save situations, the Orioles have 105 holds in addition to 20 blown saves. They are ranked 8th in MLB with a save rate of 65.5%, and they have dispatched 518 relievers to the hill on the campaign. Baltimore has called on relievers to enter the contest in 58 save opportunities and they have tallied 38 saves.

In 12,345 innings played, the Orioles hold a defensive efficiency of 68.5% (26th in baseball). The Baltimore Orioles have gotten 117 double plays and hold a fielding percentage of .985 (19th in the majors). The Orioles have accrued 1,361 assists, 83 errors and have a tally of 4,115 putouts on the campaign.

In his pro baseball career, Kremer has allowed 644 base knocks and he has 572 strikeouts in 664 frames. Kremer (40-40 mark in his career) has earned a 4.31 earned run average while giving up 8.7 hits per nine innings. He has allowed a total of 318 ER's while earning a WHIP of 1.303 and being the owner of a FIP of 4.2. His strikeout to walk ratio is 2.59 and he has gone up against 2,809 hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Baltimore (+125)

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