Washington Nationals vs Chicago Cubs Prediction, 9/7/2025 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs Chicago Cubs

Date: Sunday, September 7, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Washington (+120) Chicago (-144)

The Chicago Cubs (80-60) host the Washington Nationals (56-83) at Wrigley Field on Sunday. The odds on this game have the Nationals at +120 while the Cubs are at -144. The over/under has been set at 8.5. The starting pitchers will be Cade Cavalli and Colin Rea.

Washington is slugging .386 and have struck out 1,123 times, while being walked on 398 occasions. They have accounted for 565 RBI's in addition to 1,131 base knocks over the course of the season, and their team batting average is at .243. The Nationals have hit 229 doubles as a squad and have smacked 130 baseballs out of the stadium. They have earned a total of 588 runs and have an on-base percentage of .308. As a unit, the Washington Nationals are compiling 4.2 runs/g, which has them at 24th in MLB.

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The Nationals are sitting with a team earned run average of 5.28 this season (29th in the league), and the staff has struck out 1,070 batters. Nationals pitchers have conceded 180 home runs in addition to 758 total runs (29th in the league). They have walked 471 opposing hitters and their FIP is 4.66 as a squad this season. Washington has conceded 1,269 hits (9.4 per 9 innings) as well as 716 earned runs. They have accumulated a K/BB ratio of 2.27 and the pitching staff has earned a collective WHIP of 1.43.

Nationals relief pitchers have entered the contest with runners on base 136 times in addition to having 103 appearances in high leverage situations. The relief pitchers have 63 holds so far this season (26th in MLB). The Nationals relievers have a save rate of 65.1% and have stepped onto the mound in 107 save situations. They have tallied 28 saves over the course of the season and have blown 15 of their 43 save opportunities. The relievers have inherited 231 base runners over the course of the season and 38.5% of them crossed the plate. The Nationals have sent 494 relief pitchers to the hill this season.

The Nationals have turned 68.1% of balls in play into outs in their 10,974 innings, which has them ranked 29th in MLB. The Washington Nationals have earned 3,658 putouts this year, as well as 1,187 assists and 76 errors. Their fielding percentage sits at .985 which is 20th in baseball, and have a total of 108 double plays.

Cavalli (2-2 career mark) holds a FIP of 6.12 while going up against 158 batters during his time in the major leagues. He has allowed 42 hits (11.4 hits per 9 innings) with 10 walks. His ERA is 6.22 (23 ER's allowed) and he has a career WHIP of 1.562. Cavalli has taken the hill for 33 innings and has tallied 34 strikeouts during his pro baseball career.

The Chicago Cubs have recorded an on-base percentage of .319 as well as a team batting average of .249 on the year. They have been rung up on 1,084 occasions (27th in MLB) and have tallied 1,186 base hits. Chicago has 189 home runs this season as well as 672 runs batted in. The Cubs have a slugging percentage of .427 and they tally 4.91 runs per contest (7th in the league). They have tallied 232 doubles, while getting a free base 471 times and racking up 688 runs.

The Cubs have a team WHIP of 1.206 and have a FIP of 4.21 as a pitching staff so far this year. They have earned a K/BB ratio of 7.80 (1,073 strikeouts vs 364 walks). They come in at 11th in MLB as a staff in total hits conceded with 1,134. They have conceded 173 HR's and they allow 4.15 runs per 9 innings (7th in baseball). The Chicago pitching staff have allowed 573 runs for the season while having a team ERA of 3.88 (535 earned runs yielded).

With 149 save situations, the Cubs have compiled 93 holds in addition to 16 blown saves. Chicago has called on relievers to take the mound in 53 save opportunities and they have walked away with 37 saves. Their relievers have come in 140 times in high leverage situations and also on 90 occasions with runners on. Chicago bullpen pitchers have an inherited score rate of 31.2% out of 125 inherited base runners. They rank 4th in baseball holding a save rate of 69.8%, and they have sent 454 bullpen pitchers to the hill on the season.

The Chicago Cubs have turned 108 double plays and hold a fielding percentage of .989 (5th in MLB). The Cubs have recorded 1,172 assists, 56 errors and have accumulated 3,726 putouts so far this year. In 11,178 innings on the diamond, the Cubs hold a defensive efficiency of 71.5% (3rd in the majors).

Rea (36-26 win-loss mark in his career) has a 4.51 ERA and has surrendered 8.8 hits per nine innings. His K/BB ratio is 2.56 and he has faced 2,481 batters during his MLB career. He has allowed 292 earned runs while holding a WHIP of 1.292 and being the owner of a FIP of 4.4. During his career, Rea has allowed 571 hits while he has earned 464 K's in 582 frames.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-144) and under 8.5 runs

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