Chicago Cubs vs Cleveland Guardians Prediction, 4/4/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cleveland Guardians

Date: Saturday, April 4, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Chicago (+150) Cleveland (-182)

Progressive Field is the location where the Cleveland Guardians (4-3) will attempt to defeat the Chicago Cubs (3-3) on Saturday. The odds on this game have Chicago at +150 and Cleveland is priced at -182. The over/under is 8.5. The expected starting pitchers will be Shota Imanaga and Slade Cecconi.

Chicago is slugging .356 and have been called out on strikes 49 times, while drawing a walk on 30 occasions. They have amassed 28 RBI's in addition to 44 base knocks on the campaign, while their average at the plate sits at .227. The Cubs have accumulated 7 doubles as a team and have knocked 6 baseballs out of the park. They have accounted for 30 runs while having a team OBP of .326. As a squad, the Chicago Cubs are putting up 5.0 runs per outing, which puts them at 6th in baseball.

Get all of our MLB Picks Today

The Cubs have a team ERA of 3.50 for the season (8th in MLB), and they have rung up 61 hitters. Cubs pitchers have relinquished 7 long balls in addition to 24 total runs (9th in MLB). Their pitching staff has walked 19 opposing batters and their FIP comes in at 3.76 as a unit on the campaign. Chicago has yielded 40 base knocks (6.7 per 9 innings) and also 21 earned runs. They have accrued a K/BB ratio of 3.21 and their pitching staff holds a collective WHIP of 1.09.

The bullpen pitchers have inherited 10 runners for the year with 40.0% of them crossing home plate. Cubs bullpen pitchers have come into the game with runners on 6 times as well as having 2 appearances in high leverage situations. The Cubs have sent 17 relief pitchers to the mound for the year. The bullpen have earned no holds for the year (29th in baseball).

The Cubs have converted 73.0% of baseballs in play into outs out of their 486 innings on the field, which has them ranked 6th in MLB. The Boston Red Sox have accumulated 162 putouts at this point in the season, in addition to 56 assists and 2 errors. Their fielding percentage sits at .991 which is 10th in professional baseball, and have earned 5 double plays.

Imanaga has thrown 323 innings and has accumulated 298 punch outs during his MLB career. His ERA is 3.34 (120 ER's allowed) and his career WHIP is 1.015. He has conceded 272 hits (7.6 hits per nine innings) with 56 free passes. Imanaga (24-12 career win-loss record) has a FIP of 3.29 while facing 1,283 hitters in the majors.

The Cleveland Guardians have earned an on-base percentage of .273 and a team batting average of .189 this year. They have been rung up on 70 occasions (5th in MLB) and have notched a total of 43 hits. Cleveland has accumulated 6 HRs so far this season as well as 20 RBIs. The Guardians hold a slugging % of .322 and they are recording 3.14 runs per outing (26th in the league). They have hit 12 two-baggers, while taking a walk 20 times as well as putting up 22 runs.

The Cleveland pitching staff have given up 29 runs on the season and come in with a team ERA of 3.98 (27 earned runs conceded). They have given up 10 dingers and they give up 4.28 runs per 9 innings (12th in the league). The Guardians are sitting with a team WHIP of 1.279 with a FIP of 4.38 as a squad so far this season. Their strikeout to walk ratio comes in at 10.80 (73 strikeouts against 27 bases on balls). They are currently ranked 23rd in baseball as a pitching staff in total hits allowed with 51.

Their relief pitchers have come in 6 times in high leverage situations and on 7 occasions with runners on. They are currently ranked 15th in the league holding a save percentage of 66.7%, and they have sent 22 bullpen pitchers to the mound so far this year.

The Cleveland Guardians have turned 7 double plays and have accounted for a fielding rate of .996 (4th in the majors). The Guardians have accrued 45 assists, 1 error and have accounted for 183 putouts on the season. In 549 innings played, the Guardians have accumulated a defensive efficiency of 71.0% (15th in MLB).

Cecconi (9-16 career mark) has a 5.21 ERA while giving up 9.4 hits per nine innings. He has a K/BB ratio of 3.54 and he has gone up against 1,018 opposing batters so far in his career. He has surrendered a total of 139 earned runs while earning a WHIP of 1.274 and being the owner of a FIP of 5.1. During his career, Cecconi has given up 250 base knocks while accumulating 198 strikeouts in 240 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+150)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.