Chicago White Sox vs Milwaukee Brewers Prediction, 3/26/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Milwaukee Brewers

Date: Thursday, March 26, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: Chicago (+125) Milwaukee (-150)

The Milwaukee Brewers (97-65 last year) will play the Chicago White Sox (60-102 last season) at American Family Field on Thursday. The odds on this game have Chicago at +125 and Milwaukee is at -150. The total is 8. The pitchers who are expected to start are Shane Smith and Jacob Misiorowski.

As a unit, the Chicago White Sox knocked in 4.0 runs per game, which was 27th in the league. They earned a total of 647 runs scored while having a team on-base percentage of .302. The White Sox tallied 243 two-baggers as a unit and smacked 165 balls out of the stadium. They had 626 runs batted in in addition to 1,250 hits last season, while their batting average was .232. Chicago had a slugging % of .373 and were called out on strikes 1,364 times, while drawing a walk on 498 occasions.

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They accrued a K/BB ratio of 2.16 and their pitching staff finished with a WHIP of 1.36. White Sox pitchers surrendered 189 home runs and 742 runs (21st in MLB). Chicago relinquished 1,337 base hits (8.5 per 9 innings) in addition to 672 earned runs. The White Sox held a team ERA of 4.27 over the course of last season (20th in baseball), and the staff struck out 1,286 hitters. Their pitching staff walked 595 opposing batters and their FIP finished at 4.47 as a team during the previous year.

White Sox relief pitchers came into the game with players on base 163 times in addition to having 153 contests in high leverage situations. The relievers earned 70 holds last season (28th in MLB). The White Sox relief pitchers earned a save percentage of 51.0% and stepped onto the hill in 121 save situations. They tallied 25 saves during the previous year and did not convert 24 of 49 chances to save the game. The bullpen inherited 240 runners in the previous season with 31.7% of those players ended up crossing the plate. The White Sox dispatched 532 relievers to the hill over the course of last season.

The White Sox converted 69.6% of baseballs in play into outs out of their 12,744 innings on the field, which ranked them 19th in MLB. The Chicago Cubs notched a total of 4,248 putouts during the previous year, in addition to 1,271 assists and 99 errors. Their fielding rate was previously at .989 which ranked 4th in the majors, and they turned 131 double plays.

Smith has thrown 146 innings and is sitting with 145 strikeouts during his MLB career. Smith (7-8 win-loss record in his career) holds a FIP of 3.76 and he has faced 616 hitters during his time in the majors. His ERA is 3.82 (62 earned runs allowed) and he has a WHIP of 1.198. He has allowed 117 base knocks (7.2 hits per nine innings) with 58 free passes.

The Brewers held a team SLG% of .403 and they were scoring 4.98 runs per game (3rd in the league). They hit 265 doubles, while getting a free base 564 times and putting up 806 runs. Milwaukee had 166 HRs over the course of last year in addition to 750 RBIs. They were rung up on 1,266 occasions (26th in MLB) and earned 1,423 hits. The Milwaukee Brewers earned a team on-base percentage of .332 as well as a batting average of .258 for the prior year.

The Brewers finished with a team WHIP of 1.228 with a FIP of 3.91 as a pitching staff over the course of last season. They had a strikeout to walk ratio of 8.90 (1,432 strikeouts vs 534 walks). They were sitting at 3rd in baseball as a pitching staff in total hits allowed with 1,237. They surrendered 168 dingers and they surrendered 3.96 runs per 9 innings (3rd in baseball). The Milwaukee pitching staff allowed 634 runs during the previous year while holding an ERA of 3.58 (574 earned runs relinquished).

Milwaukee called on bullpen pitchers to take the mound in 66 save opportunities and they converted 45 saves. They were ranked 5th in the league with a save rate of 68.2%, and they dispatched 550 relief pitchers onto the field last season. Their bullpen pitchers came in 187 times in high leverage situations and on 145 occasions with base runners. Milwaukee relievers had an inherited score rate of 31.7% of 218 inherited base runners. With 177 save situations, the Brewers accrued 107 holds and 21 blown saves.

In their 12,978 innings played, the Brewers had a defensive efficiency of 70.9% (5th in baseball). The Milwaukee Brewers had 122 double plays and had a fielding rate of .987 (10th in pro baseball). The Brewers accrued 1,297 assists, 76 errors and earned 4,326 putouts last season.

Misiorowski (5-3 career record) has earned a 4.36 earned run average while allowing 7.0 hits per nine innings. His strikeout to walk ratio is 2.81 and he has faced 273 opposing hitters in his pro baseball career. He has given up a total of 32 earned runs while holding a WHIP of 1.242 and having a FIP of 4.3. During his pro baseball career, Misiorowski has given up 51 base knocks while totaling 87 punch outs in 66 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+125)

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