Chicago White Sox vs Milwaukee Brewers Prediction, 3/28/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Milwaukee Brewers

Date: Saturday, March 28, 2026

Location: American Family Field in Milwaukee, WI

TV: Brewers.TV

Odds/Point Spread: Chicago (+126) Milwaukee (-152)

American Family Field is the site where the Milwaukee Brewers (97-65 last season) will try to defeat the Chicago White Sox (60-102 last year) on Saturday. The moneyline on this matchup has the White Sox at +126 while the Brewers are coming in at -152. The betting total comes in at 8. The pitchers taking the mound will be Sean Burke and Chad Patrick.

The White Sox accumulated 243 two-baggers as a squad and smacked 165 balls out of the stadium. Chicago had a slugging % of .373 and were called out on strikes 1,364 times, while taking a walk on 498 occasions. As a unit, the Chicago White Sox put up 4.0 runs per game, which had them at 27th in baseball. They accumulated 626 RBI's in addition to 1,250 hits in the previous season, while their batting average sat at .232. They earned 647 runs scored and held an OBP of .302.

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The White Sox compiled a team earned run average of 4.27 over the course of the prior season (20th in baseball), and the staff struck out 1,286 batters. White Sox pitchers gave up 189 home runs and also 742 total runs (21st in the league). They walked 595 opposing hitters and their FIP finished at 4.47 as a unit last season. Chicago yielded 1,337 hits (8.5 per 9 innings) in addition to 672 earned runs. They accrued a K/BB ratio of 2.16 and their pitching staff had a team WHIP of 1.36.

The White Sox dispatched 532 relievers to the hill during the previous year. The relief pitchers inherited 240 base runners last year and 31.7% of those players crossed the plate. They compiled 25 saves over the course of last year and did not convert 24 of 49 save opportunities. The White Sox bullpen accumulated a save percentage of 51.0% and stepped onto the mound in 121 save situations. The relievers notched 70 holds in the prior season (28th in the league). White Sox pitchers entered the game with runners on 163 times as well as having 153 games in high leverage situations.

The White Sox transformed 69.6% of balls hit into play into outs out of their 12,744 innings, which ranked them 19th in professional baseball. The Chicago Cubs earned 4,248 putouts in the prior season, in addition to 1,271 assists and 99 errors. Their fielding rate finished at .989 which put them in 4th in the majors, and earned 131 double plays.

Burke has pitched in 153 frames and is sitting with 155 strikeouts in his career. His earned run average is 3.94 (67 earned runs allowed) and his WHIP is 1.398. He has given up 144 base hits (8.5 hits per nine innings) and has 70 walks. Burke (6-11 career record) is the owner of a FIP of 3.88 while going up against 672 opposing hitters in the major leagues.

The Brewers held a team slugging % of .403 and they scored 4.98 runs per outing (3rd in baseball). They put up 265 doubles, while taking a walk 564 times as well as putting up 806 runs. Milwaukee tallied 166 home runs last season to go along with 750 RBIs. They were rung up on 1,266 occasions (26th in MLB) and recorded 1,423 base hits. The Milwaukee Brewers earned a team OBP of .332 and a batting average of .258 for the previous season.

The Milwaukee pitching staff surrendered 634 runs over the course of last year while holding an ERA of 3.58 (574 earned runs allowed). They gave up 168 home runs and they allowed 3.96 runs per 9 innings (3rd in baseball). The Brewers finished with a team WHIP of 1.228 with a FIP of 3.91 as a staff in the previous season. They earned a K/BB ratio of 8.90 (1,432 strikeouts against 534 walks). They ranked 3rd in MLB as a staff in total hits allowed with 1,237.

Milwaukee called on relievers to enter the game in 66 save opportunities and they tallied 45 saves. They were ranked 5th in baseball with a save percentage of 68.2%, and they dispatched 550 relievers to the mound last season. Their bullpen pitchers took the field 187 times in high leverage situations and on 145 occasions with runners on. Milwaukee relievers held an inherited score percentage of 31.7% out of 218 inherited base runners. Wrapping up the year with 177 save situations, the Brewers amassed 107 holds and also 21 blown saves.

The Milwaukee Brewers turned 122 double plays and notched a fielding percentage of .987 (10th in professional baseball). The Brewers recorded 1,297 assists, 76 errors and had a total of 4,326 putouts last season. In their 12,978 innings on the field, the Brewers had a defensive efficiency of 70.9% (5th in pro baseball).

So far in his pro baseball career, Patrick has allowed 113 base hits while he has accumulated 127 K's in 119 frames. He has allowed 47 earned runs while earning a WHIP of 1.284 and a FIP of 3.5. He has a strikeout to walk ratio of 3.18 and he has faced 503 batters during his MLB career. Patrick (3-8 career mark) holds a 3.55 ERA and has surrendered 8.5 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Milwaukee (-152)

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