Cleveland Guardians vs Minnesota Twins Prediction, 9/13/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Minnesota Twins

Date: Sunday, September 13, 2026

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Cleveland (-132) Minnesota (+110)

The Minnesota Twins (69-77) will compete against the Cleveland Guardians (74-73) at Target Field on Sunday. The line on this matchup has Cleveland at -132 and Minnesota is coming in at +110. The total is set at 8.5. The pitchers taking the mound are Joey Cantillo and Joe Ryan.

As a unit, the Cleveland Guardians are scoring 4.1 runs per game, which puts them at 27th in baseball. They have tallied 598 runs while having a team on-base percentage of .314. The Guardians have hit 223 two-baggers as a team and have smacked 138 balls out of the park. They have accumulated 574 RBI's as well as 1,160 base knocks on the campaign, and their team batting average comes in at .237. Cleveland has a slugging rate of .372 and have been called out on strikes 1,175 times, while drawing a walk on 518 occasions.

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The Guardians have a team earned run average of 3.80 this season (7th in the league), and their staff has struck out 1,384 hitters. Guardians pitchers have yielded 163 home runs and also 614 runs in total (9th in the league). They have walked 486 opposing players and their FIP comes in at 3.86 as a team over the course of the season. Cleveland has conceded 1,167 base hits (8.0 per 9 innings) in addition to 552 earned runs. They have earned a strikeout to walk ratio of 2.85 and their pitching staff has a collective WHIP of 1.27.

Guardians relief pitchers have entered the contest with opponents on base 147 times in addition to having 158 appearances in high leverage situations. The bullpen have earned 102 holds so far this season (2nd in the league). The Guardians relievers have recorded a save rate of 74.1% and have come into the game in 158 save situations. They have earned 40 saves for the season and have missed out on 14 of 54 save opportunities. The relievers have inherited 233 runners this season with 27.5% of those players crossing the plate. The Guardians have dispatched 502 relievers to the mound this year.

The Cleveland Guardians have earned a total of 3,917 putouts at this point in the season, in addition to 1,140 assists and 78 errors. Their fielding percentage is holding steady at .985 which has them ranked 18th in pro baseball, and have earned 96 double plays. The Guardians have converted 69.3% of balls in play into outs out of 11,751 innings on the field, which ranks them 21st in baseball.

Cantillo has taken the ball for 278 frames and has totaled 306 punch outs in his career. His earned run average is 3.85 (119 ER's allowed) and he has a career WHIP of 1.392. He has given up 253 hits (8.2 hits per nine innings) and has had 134 walks. Cantillo (16-16 record in his career) is the owner of a FIP of 3.79 and he has faced 1,198 batters in the majors.

The Minnesota Twins have accounted for an OBP of .319 as well as a team batting average of .245 so far this season. They have been called out on strikes on 1,157 instances (24th in MLB) and have earned 1,204 base knocks. Minnesota has 172 home runs over the course of the season to go along with 645 runs batted in. The Twins have a slugging percentage of .407 and they average 4.62 runs per contest (8th in MLB). They have put up 239 doubles, while taking a walk 471 times as well as putting up 675 runs.

The Twins have a team WHIP of 1.377 and have a FIP of 4.29 as a squad so far this year. They currently have a strikeout to walk ratio of 8.60 (1,224 strikeouts vs 531 free passes). They come in at 23rd in the league as a pitching staff in total hits allowed with 1,240. They have conceded 169 homers and they give up 5.09 runs per 9 innings (26th in baseball). The Minnesota pitching staff have allowed 728 runs over the course of the season and come in with a team ERA of 4.67 (667 earned runs surrendered).

They are ranked 7th in the league holding a save percentage of 71.4%, and they have dispatched 481 bullpen pitchers to the mound this season. Their bullpen pitchers have taken the field 152 times in high leverage situations and also on 144 occasions with base runners. With 153 save situations, the Twins have recorded 93 holds and 16 blown saves. Minnesota has had relief pitchers enter the contest in 56 save chances and they have recorded 40 saves. Minnesota relievers have an inherited score percentage of 36.8% out of 209 inherited runners.

The Minnesota Twins have turned 98 double plays and own a fielding percentage of .987 (12th in pro baseball). The Twins have recorded 1,116 assists, 67 errors and have a total of 3,860 putouts for the season. Out of their 11,580 innings on the field, the Twins have a defensive efficiency of 69.2% (24th in pro baseball).

Ryan (52-45 career mark) has earned a 3.77 earned run average while conceding 7.6 hits per nine innings. He has a strikeout to walk ratio of 4.91 and he has faced 3,145 batters so far in his MLB career. He has allowed a total of 323 earned runs while earning a WHIP of 1.076 and a FIP of 3.7. In his pro baseball career, Ryan has conceded 653 hits while he has earned 864 K's in 770 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (-132)

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