St. Louis Cardinals vs Detroit Tigers Prediction, 4/4/2026 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Detroit Tigers

Date: Saturday, April 4, 2026

Location: Comerica Park in Detroit, MI

TV: Detroit SportsNet

Odds/Point Spread: St. Louis (-144) Detroit (+120)

Comerica Park is where the Detroit Tigers (2-4) will meet the St. Louis Cardinals (4-2) on Saturday. The moneyline on this contest has St. Louis at -144 and Detroit is coming in at +120. The betting total comes in at 9. The pitchers taking the mound will be Dustin May and Jack Flaherty.

As a team, the St. Louis Cardinals are putting up 4.8 runs per game, which is 9th in the league. They have tallied 29 runs and have an OBP of .287. The Cardinals have recorded 9 two-baggers as a team and have smacked 7 baseballs out of the park. They have recorded 28 RBI's in addition to 47 base knocks over the course of the season, while their average at the plate is sitting at .232. St. Louis has a slugging rate of .379 and have struck out 49 times, while drawing a walk on 17 occasions.

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The Cardinals have compiled a team ERA of 4.26 so far this year (20th in the league), and their staff has struck out 34 batters. Cardinals pitchers have yielded 2 home runs and 28 total runs (21st in the league). They have walked 26 players from the other team and their FIP is 3.85 as a team so far this year. St. Louis has conceded 59 hits (9.3 per 9 innings) as well as 27 earned runs. They have a K/BB ratio of 1.31 and their pitching staff has recorded a WHIP of 1.49.

The Cardinals have dispatched 26 relievers to the mound so far this year. The bullpen pitchers have inherited 18 runners for the season with 44.4% of them ended up crossing the plate. The relief pitchers have a total of 6 holds so far this season (6th in the league). Cardinals relief pitchers have gone to the mound with runners on 10 times and also have had 10 appearances in high leverage situations.

The St. Louis Cardinals have a tally of 171 putouts at this point in the season, as well as 63 assists and 4 errors. Their fielding percentage is currently at .983 which puts them in 20th in MLB, and they have turned 4 double plays. The Cardinals have turned 68.9% of balls in play into outs in their 513 innings on the field, which has them ranked 22nd in the majors.

May has taken the hill for 328 innings and has earned 300 K's during his career. May (19-21 career record) has a FIP of 3.92 and he has faced 1,378 batters in the majors. His ERA is 3.98 (145 ER's allowed) and he has a WHIP of 1.220. He has allowed 286 base hits (7.8 hits per 9 innings) with 114 free passes.

The Tigers have a team SLG% of .300 and they score 4.00 runs per outing (18th in MLB). They have put up 12 two-baggers, while taking a walk 22 times as well as notching 24 runs. Detroit has compiled 1 long ball so far this season to go along with 24 runs batted in. They have been called out on strikes on 60 occasions (10th in MLB) and are sitting with 43 hits. The Detroit Tigers have an OBP of .296 as well as a team batting average of .215 so far this year.

The Detroit pitching staff have given up 24 runs so far this year while having a team ERA of 3.78 (21 earned runs given up). They have surrendered 6 long balls and they allow 4.32 runs per 9 innings (13th in baseball). The Tigers hold a team WHIP of 1.320 in addition to having a FIP of 4.27 as a team for the year. They currently have a strikeout to walk ratio of 7.70 (43 strikeouts against 21 free passes). They are currently ranked 12th in MLB as a pitching staff in total hits relinquished with 45.

Their relief pitchers have come in 3 times in high leverage situations and also on 9 occasions with base runners. They sit at 21st in MLB with a save percentage of 50.0%, and they have sent 17 relief pitchers to the mound on the campaign.

The Detroit Tigers have gotten 5 double plays and have accounted for a fielding rate of .971 (26th in MLB). The Tigers have accrued 49 assists, 6 errors and have earned 150 putouts for the season. In 450 innings on the field, the Tigers have earned a defensive efficiency of 70.0% (19th in MLB).

Flaherty (63-57 career win-loss record) holds a 3.80 earned run average while allowing 7.6 hits per nine innings. He has a strikeout to walk ratio of 3.19 and he has gone up against 4,141 batters thus far in his career. He has surrendered 420 ER's while earning a WHIP of 1.202 and a FIP of 3.7. Thus far in his career, Flaherty has surrendered 840 hits while accumulating 1,132 K's in 994 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take St. Louis (-144)

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